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Wall remodeling associated with rapid luminal enlargement of collateral mesenteric arteries in rats was investigated 1 and 4 weeks after creation of a collateral pathway by ligating three to four sequential arteries. Paired observations were made of inner diameters of collateral and normal arteries in the same animals. Arterial blood flow was measured at the final observation. Sections of arteries were processed for morphological measurements. After 4 weeks, inner arterial diameter was increased more at the beginning (63 +/- 6%) than the end (25 +/- 9%) of the collateral pathway. At 1 and 4 weeks, respectively, cross-sectional areas of collateral relative to normal arteries were increased by 46 +/- 5% and 59 +/- 13% (lumen), 55 +/- 8% and 65 +/- 14% (media), and 89 +/- 18% and 60 +/- 31% (intima). The wall expansion during luminal enlargement resulted in a normal medial thickness:luminal radius relationship. At 1 week postligation, wall shear rate remained elevated and endothelial but not smooth muscle hyperplasia had occurred (intimal nuclei: 40 +/- 1.7 collateral versus 24 +/- 3.0 normal; medial nuclei: 42 +/- 6.8 collateral versus 37 +/- 2.1 normal). At 4 weeks, wall shear rate in collaterals was similar to normal arteries, and smooth muscle hyperplasia had taken place (medial nuclei: 84 +/- 9.4 collateral versus 44 +/- 4.7 normal). The data demonstrate that wall expansion associated with rapid luminal enlargement of these collaterals involves hyperplasia of both endothelial and smooth muscle cells; however, smooth muscle proliferation does not occur until after wall shear rate is reduced. The specific cellular adaptations that occur during collateral development may depend on the level of wall shear and shear-dependent modulation of endothelial growth factors.

We address the problem of interference aware routing in multi-radio infrastructure mesh networks wherein each mesh node is equipped with multiple radio interfaces and a subset of nodes serve as Internet gateways. We present a new interference aware routing metric -iAWARE that aids in finding paths that are better in terms of reduced interflow and intra-flow interference. We incorporate this metric and new support for multi-radio networks in the well known AODV routing protocol to design an enhanced AODV-MR routing protocol. We study the performance of our new routing metric by implementing it in our wireless testbed consisting of 12 mesh nodes. We show that iAWARE tracks changes in interfering traffic far better than existing well known link metrics such as ETT and IRU. We also demonstrate that our AODV-MR protocol delivers increased throughput in single radio and two radio mesh networks compared to similar protocol with WCETT and MIC routing metrics. We also show that in the case of two radio mesh networks, our metric achieves good intra-path channel diversity.

Abstract-The third-generation (3G) wide area wireless networks and 802.11 local area wireless networks possess complementary characteristics. 3G networks promise to offer alwayson, ubiquitous connectivity with relatively low data rates. 802.11 offers much higher data rates, comparable to wired networks, but can cover only smaller areas, suitable for hot-spot applications in hotels and airports. The performance and flexibility of wireless data services would be dramatically improved if users could seamlessly roam across the two networks. In this paper, we address the problem of integration of these two classes of networks to offer such seamless connectivity. Specifically, we describe two possible integration approaches -namely tight integration and loose integration and advocate the latter as the preferred approach. Our realization of the loose integration approach consists of two components: a new network element called IOTA gateway deployed in 802.11 networks, and a new client software. The IOTA gateway is composed of several software modules, and with co-operation from the client software offers integrated 802.11/3G wireless data services that support seamless intertechnology mobility, Quality of Service (QoS) guarantees and multi-provider roaming agreements. We describe the design and implementation of the IOTA gateway and the client software in detail and present experimental performance results that validate our architectural approach.

Four polymeric bone-targeting conjugates were synthesized based on poly(ethylene glycol) (PEG, two conjugates) and poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA, two conjugates). The well-known bone-targeting compounds, alendronate and aspartic acid peptide, were used as bone-targeting moieties. Fluorescein isothiocyanate (FITC) was attached to the conjugates as a model drug for detection purposes. The bone-targeting potential of these conjugates was tested in vitro with hydroxyapatite (HA) and in mice. The data obtained indicated that these novel delivery systems could specifically accumulate in the bone tissue.

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