A reference database for the Stratec XCT-2000 peripheral quantitative computed tomography (pQCT) scanner in healthy children and young adults aged 6–19 years

Abstract

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The muscle–bone unit of peripheral and central skeletal sites in children and young adults

“…Subjects participated in the Manchester 'Bone Density in Healthy Children' study. The primary aim of this cross-sectional study was to produce reference data for the clinical interpretation of bone densitometry results in children [24,25]. Recruitment for the study was through advertisement in educational institutions and general practitioner surgeries within the Greater Manchester region, United Kingdom.…”

“…Bone densitometry assessments have been described in detail for the study population [24,25]. In brief, the Hologic QDR 4500 Discovery DXA fan beam scanner (Bedford, MA, U.S.A.) was used to perform scans (fast array mode) of the whole body, from which were extracted parameters of whole and regional body composition, in accordance with manufacturer's recommendations.…”

“…Recruitment for the study was through advertisement in educational institutions and general practitioner surgeries within the Greater Manchester region, United Kingdom. Detailed recruitment and relevant inclusion and exclusion criteria for the population have been described [24,25]. Briefly, children of white Caucasian ethnic origin aged between 5 and 18 years were eligible for inclusion within the study.…”

“…1). Two Stratec XCT-2000 pQCT scanners (Pforzheim, Germany) [24] were used to scan the nondominant radius diaphysis, at the site which corresponded to 50% of forearm length. One scanner, which was purchased in the early days of pQCT, has a narrower slice width (1.2 mm) than the more modern scanner with a slice width of 2.0 mm, which is now the routine slice width of such pQCT scanners.…”

Reduced cortical bone density with normal trabecular bone density in girls with Turner syndrome

“…At the proximal radial site, cortical BMD and cortical thickness were calculated. Cortical thickness was obtained using the circular ring model in which the bone was assumed to be a cylinder pQCT results at the 4% site were compared to previously published British reference data consisting of 247 children and young adults aged between 5 and 25 years [16]. As there are no published British reference data for the 66% site, we have used Northern European reference ranges that had used identical methodology.…”