Prediction of male infertility by the World Health Organization laboratory manual for assessment of semen analysis: A systematic review

Patel, Amir Shahreza; Leong, Joon Yau; Ramasamy, Ranjith

doi:10.1016/j.aju.2017.10.005

Cited by 92 publications

(62 citation statements)

References 38 publications

(63 reference statements)

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“…According to the WHO criteria established in 2010, presented in Table 1, the seminal parameters values must fall within standard reference range, although some authors discuss in their papers about the drawbacks of using a single threshold value to distinguish the normal and abnormal values of seminal parameters (Patel et al 2018, [8]).…”

Section: Methodsmentioning

confidence: 99%

Influence of age on sperm parameters in men with suspected infertility

Silea¹,

CUCU²,

Zarnescu³

et al. 2019

Rom Biotechnol Lett

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Male fertility has become a very discussed topic among researchers in the last years. With the latest environmental changes, use of genetically modified foods, lack of physical exercise, work overload and frequent burnouts, the number of men prone to infertility is continuously increasing. In this study, we aimed to evaluate the influence of age on the sperm quality in presumably infertile males. In this purpose, we have investigated a significant number of semen samples, by using macroscopic and microscopic standard evaluation methods to determine the volume, viscosity, density, morphology, motility and vitality of spermatozoa. Our data suggest that spermatozoa viability and progressive motility, two of the most important indicators of sperm quality, decrease with age, suggesting the role of patient's age in male infertility, as well as the necessity for a better understanding of the intimate mechanisms and risks involved, as an increasing number of men are choosing to delay fatherhood.

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Section: Methodsmentioning

confidence: 99%

Influence of age on sperm parameters in men with suspected infertility

Silea¹,

CUCU²,

Zarnescu³

et al. 2019

Rom Biotechnol Lett

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“…As a result, there is significant intra-individual variability of seminal parameters, which, in one study was found between 10.3% and 26.8% (Alvarez et al, 2003). Therefore, semen analysis has its limitations in predicting the fertility potential of a man, except in cases of severe abnormalities (Patel et al, 2018). Despite these limitations, the semen analysis is an indispensable part of initial evaluation of the male partner (Esteves, 2014).…”

Section: Articlementioning

confidence: 99%

“…Unlike the previous versions of the WHO editions, the fifth edition (2010) was based on a precisely defined population, from 1953 semen samples, collected from recent fathers with TTP (Time to pregnancy) up to and including 12 months (Cooper et al, 2010). This edition was unique because it defined the reference values in terms of percentile (Cooper et al, 2010;WHO, 2010;Patel et al, 2018). Penn et al (2011) speculated that in future, such percentile range, rather than the absolute value, might be used to determine the need of intervention.…”

Section: Articlementioning

confidence: 99%

“…The lower reference value (5 th centile) mentioned in the WHO 2010 manual cannot distinguish between "fertile" and "infertile' population, because all the 1953 men, from whom the semen samples were collected were fertile (Patel et al, 2018;Murray et al, 2012). Mentioning proper reference value does not necessarily guarantee quality control and quality control by a particular laboratory (Penn et al, 2011).…”

Section: Articlementioning

confidence: 99%

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Adherence to WHO 2010 Recommendations in Relation to Semen Analysis Reports in the Laboratories of West Bengal

Dasgupta¹

2019

FandR

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Background: In 2010, The World Health Organization (WHO) suggested the standards of reporting of semen analysis and the reference values. We tried to determine the adherence to the WHO 2010 standard regarding semen analysis among the laboratories of West Bengal.Methods: An observational study was carried out by collecting the semen analysis reports from different laboratories. Compliance with the WHO 2010 recommendations regarding the reporting of semen analysis and references mentioned was subsequently analyzed.Results: A total of 211 laboratory reports were collected; of which 15 were ART (Assisted Reproductive Technology)-laboratories (7%) and 196 were non-ART-laboratories (93%). More than half of the laboratories did not mention any reference values. Only 7.5% used the phrase "WHO 2010" as the reference. Only 3% of the laboratories reported all the six "important" parameters (volume, pH, sperm concentration, motility, morphology and vitality) and used the WHO 2010 references for all of them. The ART laboratories performed significantly better than their non-ART counterparts in reporting and quoting the WHO 2010 reference values. Conclusion:Even nine years after its introduction, the compliance with the WHO 2010 recommendations on semen analysis was still low among our laboratories. There is need for increased awareness for the laboratory persons in this regard.

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“…The last (fifth) edition of the manual, published in 2010, defines serious decrease in cutoff values for sperm parameters related to chances of achieving pregnancy and thus its significance was widely discussed [3,4]. One of the strong limitations of semen analysis and the defined fertility potential references in the last WHO edition is the lack of correlation with the female age, as only 30% of infertility in couples is due to male factors alone [5,6]. The sixth edition of WHO is in discussion as some of the directions of changes would be: semen analysis references including the Asian population for reference establishment; additional separate chapters for sperm morphology and computer assisted sperm analysis (CASA); importance of microbiological assessment.…”

Section: Introductionmentioning

confidence: 99%

The Sperm: Parameters and Evaluation

Milachich¹,

Dyulgerova-Nikolova²

2020

Innovations in Assisted Reproduction Technology

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Sperm abnormalities are a major factor of human infertility. Since 1987, there are several references in different editions of World Health Organization (WHO) manual defining optimal sperm parameters. Over the years, many reproductive specialists have been constantly debating, suggesting and remodeling the frame values in those guidelines. Semen parameters have a leading role both in natural conception and assisted reproduction technologies (ART) outcomes. Deviations expressed in lower sperm count, impaired motility, abnormal morphology, and high percentage of sperm DNA fragmentation are linked to reduced chances to achieve pregnancy. In cases with low sperm count, severe oligoasthenozoospermia (OA) or azoospermia, karyotyping or evaluation with sperm aneuploidy test (SAT) could be an option and genetic counseling will be necessary if there is an obvious deviation or aberration (e.g., translocation, aneuploidy, etc.). Taking care of lifestyle factors as body mass index (BMI), diets, alcohol intake, smoking, using some additional nutrition and vitamin supplements might affect sperm parameters and contribute to the chances of a couple to conceive.

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Prediction of male infertility by the World Health Organization laboratory manual for assessment of semen analysis: A systematic review

Cited by 92 publications

References 38 publications

Influence of age on sperm parameters in men with suspected infertility

Influence of age on sperm parameters in men with suspected infertility

Adherence to WHO 2010 Recommendations in Relation to Semen Analysis Reports in the Laboratories of West Bengal

The Sperm: Parameters and Evaluation

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