Preclinical Evaluation and Clinical Translation of Magnetite-Based Nanomedicines

Nuzhina, Julia Victorovna; Shtil, Alexander А.; Prilepskii, Artur Y.; Vinogradov, Vladimir V.

doi:10.1016/j.jddst.2019.101282

Cited by 37 publications

(24 citation statements)

References 168 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Magnetite has been one of the most intensely investigated materials for biomedical applications thanks to its strong magnetic properties and biocompatibility [ 22 ]. In particular, magnetite nanoparticles (MNPs) have made an outstanding contribution to biomedicine, as in the treatment of iron deficiencies, bio-imaging, biosensors, drug delivery, and magnetic hyperthermia [ 23 ]. Furthermore, like PCL, magnetite is also approved by the FDA [ 24 ], meaning that nanocomposites combining PCL and MNPs need no additional approvals before being tested in a clinical setting.…”

Section: Introductionmentioning

confidence: 99%

Nanofibrous ε-polycaprolactone scaffolds containing Ag-doped magnetite nanoparticles: Physicochemical characterization and biological testing for wound dressing applications in vitro and in vivo

Ahmed

Zayed

El-Dek

et al. 2021

Bioactive Materials

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Nanofibrous ε-polycaprolactone scaffolds containing Ag-doped magnetite nanoparticles: Physicochemical characterization and biological testing for wound dressing applications in vitro and in vivo

Ahmed

Zayed

El-Dek

et al. 2021

Bioactive Materials

View full text Add to dashboard Cite

“…A similar modelling can be done for more complex geometries, like vessel bifurcations and aneurism, which is an urgent medical problem for targeted drug delivery using controllable MNPs [18]. Different applications of magnetite nanoparticles in living systems for bioimaging, cancer and gene therapy, and blood coagulation [19], including designing of magnetically controlled systems for targeted delivery of thrombolytic drugs for cleavage of blood clots [20], would be benefi cial from presented modeling strategy.…”

Section: Discussionmentioning

confidence: 99%

Trapping of Magnetic Nanoparticles in the Blood Stream under the Influence of a Magnetic Field

Salem¹,

Tuchin²

2020

ISUNSSP

View full text Add to dashboard Cite

Magnetic nanoparticles, as controlled drug carriers, provide tremendous opportunities in treating a variety of tumors and brain diseases. In this theoretical study, we used magnetic nanoparticles, such as Superparamagnetic Iron Oxide Nanoparticles (Fe 3 O 4) (SPION). Due to their biocompatibility and stability, these particles represent a unique nanoplatform with a great potential for the development of drug delivery systems. This allows them to be used in medicine for targeted drug delivery, in magnetic resonance imaging and magnetic hyperthermia. In the work, the trapping mechanisms of magnetic nanoparticles moving in a viscous fluid (blood) in a static magnetic field are numerically studied. The equations of motion for particles in the flow are governed by a combination of magnetic equations for the permanent magnet field and the Navier-Stokes equations for fluid (blood). These equations were solved numerically using the COMSOL Multiphysics® Modeling Software.

show abstract

“…In vivo experiments on ApoE −/− mice suggested that the combination of photothermal therapy and To date, magnetite is one of the most frequently used magnetic materials for magnetic field-based biomedicine. Its excellent biocompatibility [150], a large number of synthetic strategies to obtain magnetite of various shapes (cubic, spherical, ellipsoidal, etc.) and sizes (from 10 nm up to 10 µm) [91], and significant magnetic response (saturation magnetization of bulk magnetite is 92 emu/g) determine a routine use in a large number of papers.…”

Section: Magnetic Nanocarriers For Atherosclerosis Therapymentioning

confidence: 99%

Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis

et al. 2020

Self Cite

View full text Add to dashboard Cite

Atherosclerosis, being an inflammation-associated disease, represents a considerable healthcare problem. Its origin remains poorly understood, and at the same time, it is associated with extensive morbidity and mortality worldwide due to myocardial infarctions and strokes. Unfortunately, drugs are unable to effectively prevent plaque formation. Systemic administration of pharmaceuticals for the inhibition of plaque destabilization bears the risk of adverse effects. At present, nanoscience and, in particular, nanomedicine has made significant progress in both imaging and treatment of atherosclerosis. In this review, we focus on recent advances in this area, discussing subjects such as nanocarriers-based drug targeting principles, approaches towards the treatment of atherosclerosis, utilization of theranostic agents, and future prospects of nanoformulated therapeutics against atherosclerosis and inflammatory diseases. The focus is placed on articles published since 2015 with additional attention to research completed in 2019–2020.

show abstract

Preclinical Evaluation and Clinical Translation of Magnetite-Based Nanomedicines

Cited by 37 publications

References 168 publications

Nanofibrous ε-polycaprolactone scaffolds containing Ag-doped magnetite nanoparticles: Physicochemical characterization and biological testing for wound dressing applications in vitro and in vivo

Nanofibrous ε-polycaprolactone scaffolds containing Ag-doped magnetite nanoparticles: Physicochemical characterization and biological testing for wound dressing applications in vitro and in vivo

Trapping of Magnetic Nanoparticles in the Blood Stream under the Influence of a Magnetic Field

Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis

Contact Info

Product

Resources

About