Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis

Prilepskii, Artur Y.; Serov, Nikita; Kladko, Daniil V.; Vinogradov, Vladimir V.

doi:10.3390/pharmaceutics12111056

Cited by 30 publications

(21 citation statements)

References 192 publications

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“…One of the approaches is to incorporate a magnetic core into the nanoparticle structure. Magnetic nanoparticles (MNPs) have become a vital nanomedicine material for drug delivery, biosensing, and biocatalysis [1][2][3][4][8][9][10][11][12]. MNPs can be directed around the body with a magnetic field, allowing for directed treatment, and drug/gene delivery strategy.…”

Section: Introductionmentioning

confidence: 99%

The Effect of pH and Buffer on Oligonucleotide Affinity for Iron Oxide Nanoparticles

2021

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Magnetic Fe3O4 nanoparticles (MNPs) have great potential in the nucleic acid delivery approach for therapeutic applications. Herein, the formation of a stable complex of iron oxide nanoparticles with oligonucleotides was investigated. Several factors, such as pH, buffer components, and oligonucleotides sequences, were chosen for binding efficiency studies and oligonucleotide binding constant calculation. Standard characterization techniques, such as dynamic light scattering, zeta potential, and transmission electron microscopy, provide MNPs coating and stability. The toxicity experiments were performed using lung adenocarcinoma A549 cell line and high reactive oxygen species formation with methylene blue assay. Fe3O4 MNPs complexes with oligonucleotides show high stability and excellent biocompatibility.

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Section: Introductionmentioning

confidence: 99%

The Effect of pH and Buffer on Oligonucleotide Affinity for Iron Oxide Nanoparticles

2021

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“…Nanoparticles are known to generate reactive oxygen species upon lysosomal or cytoplasmic degradation [110][111][112]. ROS is one of the primary causes of DNA damage [113].…”

Section: Genotoxicitymentioning

confidence: 99%

Nanomaterial Shape Influence on Cell Behavior

Kladko

Falchevskaya

Serov

et al. 2021

IJMS

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Nanomaterials are proven to affect the biological activity of mammalian and microbial cells profoundly. Despite this fact, only surface chemistry, charge, and area are often linked to these phenomena. Moreover, most attention in this field is directed exclusively at nanomaterial cytotoxicity. At the same time, there is a large body of studies showing the influence of nanomaterials on cellular metabolism, proliferation, differentiation, reprogramming, gene transfer, and many other processes. Furthermore, it has been revealed that in all these cases, the shape of the nanomaterial plays a crucial role. In this paper, the mechanisms of nanomaterials shape control, approaches toward its synthesis, and the influence of nanomaterial shape on various biological activities of mammalian and microbial cells, such as proliferation, differentiation, and metabolism, as well as the prospects of this emerging field, are reviewed.

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“…Nanotechnological drugs could work especially well for the treatment of atherosclerosis as NPs are being phagocytosed by macrophages, the most abundant cell type in atherosclerotic plaques. This, together with their phagocytotic capacity opens up a new road to deliver drugs to macrophages inside atherosclerotic plaques [ 67 ]. In the following sections we will discuss potential approaches to treat CVDs with nanomedicine.…”

Section: Therapeutic Nanomedicine-based Approachesmentioning

confidence: 99%

Immunomodulatory Nanomedicine for the Treatment of Atherosclerosis

Peters

Jans

Bartneck

et al. 2021

JCM

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Atherosclerosis is the main underlying cause of cardiovascular diseases (CVDs), which remain the number one contributor to mortality worldwide. Although current therapies can slow down disease progression, no treatment is available that can fully cure or reverse atherosclerosis. Nanomedicine, which is the application of nanotechnology in medicine, is an emerging field in the treatment of many pathologies, including CVDs. It enables the production of drugs that interact with cellular receptors, and allows for controlling cellular processes after entering these cells. Nanomedicine aims to repair, control and monitor biological and physiological systems via nanoparticles (NPs), which have been shown to be efficient drug carriers. In this review we will, after a general introduction, highlight the advantages and limitations of the use of such nano-based medicine, the potential applications and targeting strategies via NPs. For example, we will provide a detailed discussion on NPs that can target relevant cellular receptors, such as integrins, or cellular processes related to atherogenesis, such as vascular smooth muscle cell proliferation. Furthermore, we will underline the (ongoing) clinical trials focusing on NPs in CVDs, which might bring new insights into this research field.

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Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis

Cited by 30 publications

References 192 publications

The Effect of pH and Buffer on Oligonucleotide Affinity for Iron Oxide Nanoparticles

The Effect of pH and Buffer on Oligonucleotide Affinity for Iron Oxide Nanoparticles

Nanomaterial Shape Influence on Cell Behavior

Immunomodulatory Nanomedicine for the Treatment of Atherosclerosis

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