Practical synthesis and characterization of mannose-modified chitosan

Yao, Wenjun; Jiao, Yuanmei; Luo, Jingchu; Du, Mingzhu; Zong, Li

doi:10.1016/j.ijbiomac.2011.11.019

Cited by 29 publications

(26 citation statements)

References 22 publications

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“…The result from this study is consistent with many previous studies [26,29,52], which have demonstrated that there was a difference in FITR profile between chitosan and CLCG. The peaks of chitosan at 1363 cm −1 and 1155 cm −1 disappeared, indicating that the two peaks may be hindered by glutaraldehyde cross-linked structure of chitosan.…”

Section: Resultssupporting

confidence: 93%

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Synthesis, Characterization, and Antibacterial Activity of Cross-Linked Chitosan-Glutaraldehyde

et al. 2013

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This present study deals with synthesis, characterization and antibacterial activity of cross-linked chitosan-glutaraldehyde. Results from this study indicated that cross-linked chitosan-glutaraldehyde markedly inhibited the growth of antibiotic-resistant Burkholderia cepacia complex regardless of bacterial species and incubation time while bacterial growth was unaffected by solid chitosan. Furthermore, high temperature treated cross-linked chitosan-glutaraldehyde showed strong antibacterial activity against the selected strain 0901 although the inhibitory effects varied with different temperatures. In addition, physical-chemical and structural characterization revealed that the cross-linking of chitosan with glutaraldehyde resulted in a rougher surface morphology, a characteristic Fourier transform infrared (FTIR) band at 1559 cm−1, a specific X-ray diffraction peak centered at 2θ = 15°, a lower contents of carbon, hydrogen and nitrogen, and a higher stability of glucose units compared to chitosan based on scanning electron microscopic observation, FTIR spectra, X-ray diffraction pattern, as well as elemental and thermo gravimetric analysis. Overall, this study indicated that cross-linked chitosan-glutaraldehyde is promising to be developed as a new antibacterial drug.

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Section: Resultssupporting

confidence: 93%

“…The contents of carbon, hydrogen and nitrogen elements in chitosan and CLCG were determined according to the method of Yao et al [52], which were performed on a vario microorganic elemental analyzer (CE Intrusment EA1112, Italy).…”

Section: Methodsmentioning

confidence: 99%

Synthesis, Characterization, and Antibacterial Activity of Cross-Linked Chitosan-Glutaraldehyde

et al. 2013

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“…The result showed that CS was slightly more exothermic than MCH. These results indicated that, in some extent, the thermal stability of MCH was slightly decreased compared with CS, due to the introduction of the mannose residue and change in the crystallinity of CS [31].…”

Section: Thermal Analysismentioning

confidence: 87%

Development and physicochemical, toxicity and immunogenicity assessments of recombinant hepatitis B surface antigen (rHBsAg) entrapped in chitosan and mannosylated chitosan nanoparticles: as a novel vaccine delivery system and adjuvant

Mehrabi

Dounighi

Sorkhabadi

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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In this study chitosan nanoparticles (CS NPs) and mannosylated chitosan nanoparticles (MCH NPs) loaded with recombinant hepatitis B surface antigen (rHBsAg) was synthesized as a vaccine delivery system and assessed toxically and immunologically. The physicochemical properties of the nanoparticles (NPs) were determined by methods including scanning electron microscope (SEM) and dynamic light scattering (DLS). The morphology of the NPs was semi spherical and the average diameter of the loaded CS and MCH NPs was found to be 189 and 239 nm, respectively. The release studies showed that after the initial burst, both of the loaded NPs provided a continuous and slow release of the antigens. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay showed concentration and time dependent toxicity profile for both formulations, but rHBsAg loaded CS nanoparticle showed higher toxicity due to smaller particle size and larger zeta potential. Abnormal toxicity test (ATT) results showed no signs of toxicity in mice and guinea-pigs treated with loaded MCHNPs. Stability test for six months showed acceptable changes in size, surface charge, and antigenicity for loaded MCH nanoparticles. Finally, in vivo immunogenicity study revealed greater adjuvant capability of MCH nanoparticles than others formulations. Our results showed MCH NPs can be used as a controlled and targeted vaccine delivery system.

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“…The second mass loss peak appeared at the onset temperature for decomposition in all the samples. This stage may be attributed to the decomposition of mannose residues attached to chitosan and the chain degradation of chitosan (Yao, Jiao, Luo, Du, & Zong, ).…”

Section: Resultsmentioning

confidence: 99%

Properties of a novel carboxymethyl chitosan derived from silkworm pupa

Zhu

Zou

Fan

et al. 2018

Arch Insect Biochem Physiol

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In this study, a carboxymethyl chitosan derived from silkworm pupa (SP-carboxymethyl chitosan) was prepared. The physical characteristics of the SP chitin, chitosan, and carboxymethyl chitosan were analyzed. The scanning electron microscopy results showed that the surfaces of the samples from SP were more uneven, with more surface fractures compared with those of the reference substance (RS). Thermal analysis, X-ray photoelectron spectroscopy, and Fourier transform infrared spectroscopy analysis showed that the main molecular chain structures of SP samples and RSs had no substantial differences. However, the crystallinity and thermal decomposition temperature of the SP samples were lower compared with those of the RSs. All of these results provide a theoretical basis for the development of applications for the SP-carboxymethyl chitosan.

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Practical synthesis and characterization of mannose-modified chitosan

Cited by 29 publications

References 22 publications

Synthesis, Characterization, and Antibacterial Activity of Cross-Linked Chitosan-Glutaraldehyde

Synthesis, Characterization, and Antibacterial Activity of Cross-Linked Chitosan-Glutaraldehyde

Development and physicochemical, toxicity and immunogenicity assessments of recombinant hepatitis B surface antigen (rHBsAg) entrapped in chitosan and mannosylated chitosan nanoparticles: as a novel vaccine delivery system and adjuvant

Properties of a novel carboxymethyl chitosan derived from silkworm pupa

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