Powder Microscopic, Physicochemical, HPTLC and Antioxidant Studies on Noccik Kudinir Chooranam – A Polyherbal Siddha Formulation

Thatipelli, Sujith; Shakila, R; Mandal, Achintya Kumar; Kesanakurti, Divya; Francis, Mahesh; Kumar, Koppala Narayana Sunil; Rethinam, Ganesan

doi:10.5530/jyp.2019.11.76

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…These studies of these formulations confirmed the presence of all the ingredients such as C. angustifolia, Z. officinale, P. nigrum, E. ribes and T. ammi as per Siddha literature ˝Siddha vaithiya thirattu 4 . Previously these powder microscopic techniques were carried out for noccik kudineer choornam 19 .…”

Section: Powder Microscopic Studiesmentioning

confidence: 99%

Identification of Bioactive Molecules in Traditional Siddha Formulation “Nilaavarai Choornam”

Selva Sivagami,

Abirami Swetha,

Swetha

et al. 2024

JNR

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The Siddha system of medicine is developed by ancient Tamil Siddhars, through their spiritual power. In the present work, the Siddha herbal formulation Nilaavarai choornam (NVC) is selected and chemically evaluated for its major active constituents. All standardization parameters were evaluated for the in-house and market samples of NVC. These parameters will also be useful in checking the quality of the ingredients and the end product. Its ingredients are senna, ginger, black pepper, ajowan and embelia. It is administered to treat constipation, indigestion, flatulence and intestinal worms. Pharmacognostic parameters of Nilaavarai choornam were determined through powder microscopy and chemical studies. Preliminary phytochemical screening was carried out using petroleum ether, chloroform, acetone, alcohol and water extracts obtained through successive extraction methods. Fluorescence analysis was also performed to detect chromophores present in this formulation. HPTLC Fingerprinting profile was determined to identify the active molecules present in this formulation. Powder microscopy of this formula suggested the presence of characteristic, calcium crystals, oleoresin, stone cells, endosperm cells, striated cuticle and parenchyma cells. The powdered material showed 2.8% loss on drying for NVC-M and 2.5% for NVC-H, 3% of ash for both samples and 0.54% of acid insoluble ash for NVC-M and 0.09% for NVC-H. Preliminary phytochemical screening of various extracts revealed the presence of proteins, sterols, terpenoids, carbohydrates, flavonoids, tannins, quinones, alkaloids and glycosides. The HPTLC fingerprinting profile of the chloroform fraction of NVC-M and NVC-H showed characteristic spots. Also, HPTLC determination was done with the standard gingerol and piperine and the results obtained confirmed the presence of active ingredients in both the samples.

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Section: Powder Microscopic Studiesmentioning

confidence: 99%

Identification of Bioactive Molecules in Traditional Siddha Formulation “Nilaavarai Choornam”

Selva Sivagami,

Abirami Swetha,

Swetha

et al. 2024

JNR

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“…Plants have been the basis of many traditional medicines throughout the world for thousands of years due to their therapeutic efficacy. It is estimated that herbal medicine in developed countries make up to one fourth; while in developing countries it is up to three fourth of all medicines (1). The use of herbal drugs is rapidly increasing worldwide as the herbal drugs were found to be beneficial in treating mild to moderate diseases in all age groups and in averting illnesses thereby promoting health (2).…”

Section: Introductionmentioning

confidence: 99%

Detection of adulteration of Decalepis hamiltonii Wight & Arn. with Hemidesmus indicus (L.) R. Br. by pharmacognostic, molecular DNA fingerprinting by RAPD, chemical and HPTLC studies

et al. 2021

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Hemidesmus indicus (L.) R. Br. (Apocynaceae) root is extensively used in Indian traditional systems due to its biological activities. Decalepis hemiltonii Wight & Arn. is another member from the same family resembling H. indicus and is adulterated in the herbal market. Aim of the study was to compare and evaluate the distinguishing features based on macroscopy, microscopy, powder microscopy, molecular differences in the genomic DNA by RAPD, physiochemical, phytochemical screening, TLC and HPTLC fingerprint profiling of successive extracts. Microscopically cork, cortex, phloem, xylem, medullary rays and pith; powder microscopically size and shape of the cork cells, fibre, fibre tracheids, vessels, xylem parenchyma cells were different from each other. Polymorphism (75.4 %) was found in eight primers out of 16 primers analyzed. The water soluble extractive and the hexane soluble extractive of D. hamiltonii was higher than H. indicus. Tannins, flavonoids, steroids and coumarins were present only in H. indicus and absent in D. hamiltonii. After derivatization, spots at Rf 0.88 (hexane extract), 0.81 (chloroform extract) and 0.55 (ethanol extract) in H. indicus; spots at Rf 0.22, 0.45 (chloroform extract), 0.19, 0.35, 0.58, 0.59 (ethanol extract) in D. hamiltonii were observed. This study will be helpful to find out adulteration of D. hemiltonii in place of H. indicus sold in the crude drug market and in herbal formulations.

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Powder microscopic, physicochemical and chromatographic approach for the quality control of anti-hypertensive drug Rattha Piththathirku Kudinir Chooranam

et al. 2021

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The present work aims to study powder microscopy, physicochemical and high-performance thin-layer chromatography photo documentation and fingerprint profiles of a Siddha drug, Rattha Piththathirku Kudinir Chooranam (RPK). The raw drugs were collected, authenticated and the RPK was prepared. Then the drug was investigated for powder microscopic characters, physicochemical parameters, Thin Layer Chromatographic photo documentation (TLC), High-Performance Thin-Layer Chromatographic (HPTLC) fingerprint profiles of successive n-hexane, successive chloroform, successive ethanol and hydro alcohol (1:1) extracts. The successive and hydro alcohol extracts of the drug displayed distinct TLC spots and HPTLC peaks which are distinct to this drug.

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Powder Microscopic, Physicochemical, HPTLC and Antioxidant Studies on Noccik Kudinir Chooranam – A Polyherbal Siddha Formulation

Cited by 3 publications

References 19 publications

Identification of Bioactive Molecules in Traditional <i>Siddha</i> Formulation <i>“Nilaavarai Choornam”</i>

Identification of Bioactive Molecules in Traditional <i>Siddha</i> Formulation <i>“Nilaavarai Choornam”</i>

Detection of adulteration of Decalepis hamiltonii Wight & Arn. with Hemidesmus indicus (L.) R. Br. by pharmacognostic, molecular DNA fingerprinting by RAPD, chemical and HPTLC studies

Powder microscopic, physicochemical and chromatographic approach for the quality control of anti-hypertensive drug Rattha Piththathirku Kudinir Chooranam

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