Potential use of niosomes for encapsulation of nisin and EDTA and their antibacterial activity enhancement

Kopermsub, Phikunthong; Mayen, Varissaporn; Warin, Choochart

doi:10.1016/j.foodres.2010.12.011

Cited by 75 publications

(41 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar results have been reported (26,49,50). Manosroi et al (49) attributed negative zeta potentials of blank and gallidermin loaded niosomes to the hydroxyl group in cholesterol molecule with uneven distribution of polarity.…”

Section: Characteristics Of Niosomessupporting

confidence: 79%

“…Being more physicochemically stable, easily handled, and less expensive, niosomes overcome the main limitations of liposomes. Niosomes are recognized to control the release and enhance the activity of antimicrobial agents including antibiotics (24,25), antibacterial, and antifungal agents (26)(27)(28) and to interact with phospholipid membranes (29). The use of hydrophilic polyethoxylated surfactants such as Tweens and Brijs either alone (30,31) or in combination with lipophilic surfactants (cosurfactant niosomes) (32) confers bilayer hydrophilicity which enhances entrapment of hydrophilic drugs and may prevent bacterial adhesion at niosome-treated surfaces.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Vancomycin-Eluting Niosomes: A New Approach to the Inhibition of Staphylococcal Biofilm on Abiotic Surfaces

et al. 2014

View full text Add to dashboard Cite

Abstract. A new vancomycin (VCM)-eluting mixed bilayer niosome formulation was evaluated for the control of staphylococcal colonization and biofilm formation on abiotic surfaces, a niosome application not explored to date. Cosurfactant niosomes were prepared using a Span 60/Tween 40/cholesterol blend (1: 1: 2). Tween 40, a polyethoxylated amphiphile, was included to enhance VCM entrapment and confer niosomal surface properties precluding bacterial adhesion. VCM-eluting niosomes showed good quality attributes including relatively high entrapment efficiency (∼50%), association of Tween 40 with vesicles in a constant proportion (∼87%), biphasic release profile suitable for inhibiting early bacterial colonization, and long-term stability at 4°C for a 12-month study period. Niosomes significantly enhanced VCM activity against planktonic bacteria of nine staphylococcal strains. Using microtiter plates as abiotic surface, VCM-eluting niosomes proved superior to VCM in inhibiting biofilm formation, eradicating surface-borne biofilms, inhibiting biofilm growth, and interfering with biofilm induction by VCM subminimal inhibitory concentrations. Data suggest dual functionality of cosurfactant VCM-eluting niosomes as passive colonization inhibiting barrier and active antimicrobial-controlled delivery system, two functions recognized in infection control of abiotic surfaces and medical devices.

show abstract

Section: Characteristics Of Niosomessupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Vancomycin-Eluting Niosomes: A New Approach to the Inhibition of Staphylococcal Biofilm on Abiotic Surfaces

et al. 2014

View full text Add to dashboard Cite

show abstract

“…In this study, when the hydration is performed at 70 C, the vesicle size is seen to be larger than at room temperature, which is in agreement with the other literature report (Kopermsub et al, 2011). The results explain that greater molecular kinetic energy at higher temperature leads to a decrease in bilayer thickness, thereby increasing the rate of fusion or diffusion.…”

Section: Effect Of Hydration Temperaturesupporting

confidence: 92%

PEGylated non-ionic surfactant vesicles as drug delivery systems for Gambogenic acid

et al. 2013

View full text Add to dashboard Cite

Gambogenic acid (GNA), a popular Chinese traditional medicine, has its limitations of coming into use due to its low aqueous solubility and poor bioavailability. In this study, therefore, the PEGylated non-ionic surfactant vesicles drug delivery systems were prepared from biocompatible non-ionic surfactant of Span60, cholesterol and dicetyl phosphate (DCP) by the improved ethanol injection method, and were modified with a polyethylene glycol monostearate15 (PEG15-SA). PEG15-SA, as a biocompatible, non-toxic and non-immunogenic hydrophilic segment, was grafted onto the surface of colloidal niosomes carries to reduce the uptake by the reticuloendothelial system (RES), prolonging the circulation time and attaining higher entrapment efficiency. To our knowledge, this work is the first to report that PEG15-SA was applied to coating of niosomes for encapsulation of GNA. The optimized PEG-GNA-NISVs (P-GNA-NISVs) were characterized in terms of mean vesicles size, polydispersity index (PDI), Zeta potential and entrapment efficiency of the P-GNA-NISVs. The results showed that the mean diameter, PDI, Zeta potential, and the entrapment efficiency of the P-GNA-NISVs were 70.1 nm, 0.166, À44.3 mV and 87.74%, respectively. Furthermore, the release studies of GNA from PEGylated niosomes in vitro and the pharmacokinetics in vivo exhibited a prolonged release profile as studied over 24 h. In conclusion, the result suggests that P-GNA-NISVs prepared in this way not only have higher encapsulation capacity, more colloidal stability but also offer an approach that the PEGylated niosomes is a promising carrier for anticancer GNA.

show abstract

“…Monolaurin, a monoester of lauric acid, is used in food production because of its flavoring and emulsifying effect and has been found to have antimicrobial properties against Gram-positive bacteria (14,15). EDTA is the most widely used chelating agent with strong activity against the lipopolysaccharide layer of Gram-negative cells, making them sensitive to other antimicrobials such as nisin and lactoferrin (13,16). In this study, different concentrations of cinnamon essential oil, monolaurin, and nisin were used alone and in combination to determine the antibacterial effect of these components on E. coli and S. aureus.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Effect of Cinnamon Essential Oil Against Escherichia Coli and Staphylococcus aureus

et al. 2015

View full text Add to dashboard Cite

Background:Various studies have been conducted to determine the effects of essential oils and other natural antimicrobials on foodborne pathogens in culture media. Objectives: The present study aimed to determine the antibacterial effects of cinnamon essential oil, monolaurin, nisin, and ethylenediaminetetraacetic acid (EDTA) alone and in combination, in culture media. Materials and Methods: Cinnamon essential oil was analyzed by gas chromatography/mass spectrometry (GC/MS) and the major component was identified as cinnamaldehyde. Broth microdilution assay and agar disk diffusion method were used to evaluate the antibacterial effect of cinnamon essential oil, monolaurin, nisin, and EDTA alone and in combination against Staphylococcus aureus and Escherichia coli. Results: The MIC of cinnamon essential oil, monolaurin, nisin, and EDTA for S. aureus was 3125.00, > 500.00, > 125.00, and > 250.00 µg/ mL, respectively, while the MIC of the aforementioned materials for E. coli was 780.00, 31.25, 15.60, and 250.00 µg/mL. In the present study, S. aureus was found to be more sensitive than E. coli and monolaurin and nisin showed the lowest MIC for E. coli. Increased antimicrobial effect was observed when cinnamon essential oil was used in combination with nisin, monolaurin, and EDTA. Conclusions: The present study showed that cinnamon essential oil when used in combination with nisin, monolaurin or EDTA demonstrated stronger antimicrobial effect against foodborne pathogens than when used alone.

show abstract

Potential use of niosomes for encapsulation of nisin and EDTA and their antibacterial activity enhancement

Cited by 75 publications

References 32 publications

Vancomycin-Eluting Niosomes: A New Approach to the Inhibition of Staphylococcal Biofilm on Abiotic Surfaces

Vancomycin-Eluting Niosomes: A New Approach to the Inhibition of Staphylococcal Biofilm on Abiotic Surfaces

PEGylated non-ionic surfactant vesicles as drug delivery systems for Gambogenic acid

Antimicrobial Effect of Cinnamon Essential Oil Against Escherichia Coli and Staphylococcus aureus

Contact Info

Product

Resources

About