Antibacterial materials containing
biocides suffer from the fact
that biocides are usually quickly released and hence display a limited
antibacterial ability over a long period of time. To overcome this
problem, the antibacterial agent 6-chloropurine is conjugated to a
monomer via a hemiaminal ether linkage. The functional monomer is
then reacted with a urethane acrylate by photopolymerization to yield
thin polymer coatings. The release of the antibacterial agent from
the coatings is sustained due to the slow kinetics of the hydrolysis
of the hemiaminal ether linkage. Antibacterial performance is achieved
against S. aureus and E. coli bacteria. This simple strategy can be applied
for the rapid preparation of antibacterial coatings on various substrates
and other applications such as antifouling or anticorrosion coatings.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.