Potential hepatoprotective effects of vitamin E and<i>Nigella sativa</i>oil on hepatotoxicity induced by chronic exposure to malathion in human and male albino rats

El-Gharieb, Mahmood A.; El‐Masry, Thanaa A.; Emara, Ashraf M.; Hashem, Mohammed A.

doi:10.1080/02772240902955719

Cited by 35 publications

(24 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, administration of vitamin E in combination with atrazine exposure resulted in statistically significant decrease in LPO of liver of the fish when compared with fish exposed to atrazine alone. The results agreed with El-Gharieb et al (2010) and Singh et al (2011).…”

Section: Resultssupporting

confidence: 81%

Vitamin E as antioxidant in female african catfish (Clarias gariepinus) exposed to chronic toxicity of atrazine

Kadry

Amer

Marzouk

et al. 2012

Egypt. J. of Aquatic Biolo. and Fish.

View full text Add to dashboard Cite

The present study was planned aiming to investigate the effects of atrazine herbicide exposure on stress biomarkers acetylcholinesterase activity (AchE) and cortisol, oxidative stress responses and the histopathological changes in liver of female Clarias gariepinus and the ameliorative effect of vitamin E supplementation (240mg/kg diet) on the degree of atrazine sublethal toxicity (1.37mg/l) for 6 weeks. Chronic exposure to atrazine revealed a marked inhibition in the activity of AchE. But, significant increase of serum cortisol level was recorded. Moreover, atrazine exposure was associated with a marked induction of oxidative damage in liver tissue as evidenced by increased level of lipid peroxidation (LPO) and reduced glutathione (GSH) content. Atrazine exposure also led to a significant increase in the activities of catalase (CAT) and superoxide dismutase (SOD).Furthermore, histopathological examination of the liver of exposed fish showed dilatation and congestion of blood vessels, fatty degeneration, necrosis and pyknotic nuclei of hepatocytes. However, fish fed diet supplemented with vitamin E exhibited protective effect by minimizing the atrazine-induced toxicity, through measured values more or less similar to the control group fish.

show abstract

Section: Resultssupporting

confidence: 81%

Vitamin E as antioxidant in female african catfish (Clarias gariepinus) exposed to chronic toxicity of atrazine

Kadry

Amer

Marzouk

et al. 2012

Egypt. J. of Aquatic Biolo. and Fish.

View full text Add to dashboard Cite

show abstract

“…This dose equal to 1/50 of the LD50 according to EI-Gharieb et al (2008) Group III: Animal were given Malathion at a dose of 50 mg/kg BW/day in 0.2 mL corn oil per animal via gavages for four weeks plus vitamin C by dose (200 mg/kgBW/day) in 0.2 mL propalin glycol via gavages for four weeks Groups IV: Animal were given Malathion at a dose of 50 mg/kg BW/day in corn oil per animal via gavages for four weeks with green tea by dose (36 mg/kg BW/day). In 0.2 mL distilled water via gavages for four weeks…”

Section: Experimental Designmentioning

confidence: 99%

Protective Role of Vitamin C and Green Tea Extract on Malathion-Induced Hepatotoxicity and Nephrotoxicity in Rats

Elzoghby¹,

Hamoda²,

Aboubakr³

et al. 2014

American Journal of Pharmacology and Toxicology

View full text Add to dashboard Cite

The present study was designed to determine the modulating effect of green tea and vitamin C against adverse effects of malathion. Animals were divided into four groups 5 rats /group). Group one was used as a control. Group two given malathion (50 mg/kg/day; 1/50 of the LD50 for four weeks). Group three and Group four were given malathion (50 mg/kg/day; 1/50 of the LD50 for four weeks) plus vitamin C (200 mg/kg/day) and plus green tea (36 mg/kg/day) respectively. At the end of the fourth week, the malathion-treated group had significantly lower Red Blood Cell count (RBCs), Hemoglobin concentration (Hb), Packed Cell Volume (PCV%) and leucocytes (WBCs) than the control group. Compared to the control group, the malathion-treated group had significantly higher serum Alkaline Phosphatase (ALP), Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Lactate Dehydrogenase (LDH), urea, creatinine and uric acid levels than the control group. The malathion treated rats also had significantly lower serum total protein, albumin and globulin levels than the control group, but the malathion plus vitamin C and malathion plus green tea groups did not differ from the control group in terms of these parameters. Moreover, concomitant vitamin C and green tea treatment significantly normalized, at least partially, all of the other hematological and biochemical parameters that were altered by malathion. Liver tissue homogenate in malathion treated group had lower Glutathione (GSH), Glutathione Peroxidase (GSH-PX) and Superoxide Dismutase (SOD) levels accompanied with higher level of Malondialdehyde (MDA) than the control group. Histopathological studies revealed that the malathion-treated, malathion plus vitamin C and malathion plus green tea treated groups exhibited histopathological changes in liver and kidney tissues, although some pathological features were only observed in the malathion-treated group. Thus, vitamin C and green tea can reduce malathion hepatotoxicity and nephrptoxicity.

show abstract

“…This dose equal to 1/50 of the LD50. 8 Group IV was given a mixture of 400 mg ginger per kg body weight and ZnCl 2 (300 mg/L) diluted in tap water in addition to 100 mg malathion/kg body weight for 4 months. At the end of the experiment, the livers and kidneys were collected for histopathological and immunohistochemical studies.…”

Section: Experimental Designmentioning

confidence: 99%

Protective effect of ginger and zinc chloride mixture on the liver and kidney alterations induced by malathion toxicity

Baiomy

Attia

Soliman

et al. 2015

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

This study was carried out on four groups of male Wistar rats, 10 rats per group. Group I got open access to food intake and water with normal balanced diet. Group II was administered 400 mg ginger per kg body weight (BW) and zinc chloride (ZnCl2) (300 mg/L) diluted in tap water for 4 months. Group III was administered malathion at a dose of 50 mg/kg BW/day in 0.2 mL corn oil via gavages for 4 months. This dose equal to 1/50 of the LD50. Group IV was given a mixture of 400 mg ginger per kg BW and ZnCl2 (300 mg/L) diluted in tap water in addition to 100 mg malathion/kg BW for 4 months. The liver showed histopathological changes include congestion, edema, and leucocytic infiltrations which were ameliorated by the addition of ginger and ZnCl2 mixture. The kidney showed cloudy swelling and hydropic degeneration of the renal tubules. These changes were ameliorated by the addition of ginger and ZnCl2 mixture. Ki67 immunoreactivity was localized in the cytoplasm and nuclear membrane. Its expression was estimated as the percentage of cells positively stained by the antibody in the different groups. In conclusion, malathion was toxic to the liver and kidney and must be avoided and protected by the addition of ginger and zinc mixture.

show abstract

Potential hepatoprotective effects of vitamin E andNigella sativaoil on hepatotoxicity induced by chronic exposure to malathion in human and male albino rats

Cited by 35 publications

References 45 publications

Vitamin E as antioxidant in female african catfish (Clarias gariepinus) exposed to chronic toxicity of atrazine

Vitamin E as antioxidant in female african catfish (Clarias gariepinus) exposed to chronic toxicity of atrazine

Protective Role of Vitamin C and Green Tea Extract on Malathion-Induced Hepatotoxicity and Nephrotoxicity in Rats

Protective effect of ginger and zinc chloride mixture on the liver and kidney alterations induced by malathion toxicity

Contact Info

Product

Resources

About