Protective effect of ginger and zinc chloride mixture on the liver and kidney alterations induced by malathion toxicity

Abstract

This study was carried out on four groups of male Wistar rats, 10 rats per group. Group I got open access to food intake and water with normal balanced diet. Group II was administered 400 mg ginger per kg body weight (BW) and zinc chloride (ZnCl2) (300 mg/L) diluted in tap water for 4 months. Group III was administered malathion at a dose of 50 mg/kg BW/day in 0.2 mL corn oil via gavages for 4 months. This dose equal to 1/50 of the LD50. Group IV was given a mixture of 400 mg ginger per kg BW and ZnCl2 (300 mg/L) diluted in tap water in addition to 100 mg malathion/kg BW for 4 months. The liver showed histopathological changes include congestion, edema, and leucocytic infiltrations which were ameliorated by the addition of ginger and ZnCl2 mixture. The kidney showed cloudy swelling and hydropic degeneration of the renal tubules. These changes were ameliorated by the addition of ginger and ZnCl2 mixture. Ki67 immunoreactivity was localized in the cytoplasm and nuclear membrane. Its expression was estimated as the percentage of cells positively stained by the antibody in the different groups. In conclusion, malathion was toxic to the liver and kidney and must be avoided and protected by the addition of ginger and zinc mixture.

Organophosphate toxicity: updates of malathion potential toxic effects in mammals and potential treatments

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Dietary Capsaicin Protects Cardiometabolic Organs from Dysfunction

“…A lot of protective natural compounds had been found for their neuroprotective properties in preventing diseases and inflammation [ 1 , 2 , 3 , 4 ]. Chili peppers have become a vital part of culinary cultures worldwide and have a long history of use for flavoring, coloring, and preserving food, as well as for medical purposes.…”

The Potential Protective Effect of Sesame Oil and Canola Oil on Rats Exposed to Malathion

“…However, it is known that increase of creatinine occurred with renal failure (Hayes, 1994). Previous investigations showed a significant enhancement of blood creatinine, urea and uric acid levels, and renal histological changes in experimental animals exposed to malathion and other pesticides (Al-Attar, 2015;Baiomy et al, 2015;Kanbur et al, 2016;Li et al, 2016;Kaya et al, 2018;Muhammad et al, 2019).…”

“…One of the main toxic effects of malathion on the central nervous system is related to the inhibition of acetylcholinesterase (AChE) activity, which produces acute hypercholinergic syndrome (Kwong, 2002). Moreover, previous experimental investigations showed that malathion induced various biochemical and histological changes in experimental animals (Baiomy et al, 2015;Abdel-Salam et al, 2018;Gupta et al, 2019;Hosseini et al, 2019).…”