The Potential Protective Effect of Sesame Oil and Canola Oil on Rats Exposed to Malathion

Abstract

Currently, the environmental pollution is occurring on a vast and unprecedented scale around the globe. Pesticides are the largest group of chemicals that are used widely in modern agricultural practices. Pesticides have been associated with health and environmental issues, and the agricultural use of certain pesticides has been abandoned. Pesticides are basically poisons and therefore toxic to living organism at particular dose. Medicinal plants have a promising future because there are about half million plants around the world, and most of them their medical activities have not investigate yet, and their medical activities could be decisive in the treatment of present or future studies. Natural products from plants, animals and minerals are the basis for treating human diseases. The purpose of the present study was to evaluate the effects of sesame oil and canola oil on male rats exposed to malathion. Experimental rats were divided into six groups. Group 1 was served as normal control. Rats of group 2 were exposed to malathion. Rats of group 3 were treated with sesame oil and malathion. Rats of group 4 were subjected to canola oil and malathion. Rats of group 5 and 6 were supplemented with sesame oil and canola oil respectively. After the end of experimental duration (8 weeks), rats of group 2 showed significant reduction of body weight gain, and severe hematological and biochemical alterations including significant decreases of RBC, HB, Hct, WBC, total protein, glucose and CAT, and increases of ALT, AST, ALP, total bilirubin, triglycerides, cholesterol, creatinine, uric acid and MDA values. Administration of sesame oil and canola oil improved the observed hematological and biochemical alterations induced by malathion intoxication. These new findings indicate that sesame oil and canola oil represent protective roles on hematological and biochemical disturbances induced by malathion toxicity due to their antioxidant activities.