Potential effect of romifidine with lidocaine administration in goats

Kinjavdekar, P.; Aithal, H. P.; Amarpal,; Pawde, A. M.; Pratap, K.; Singh, G. R.

doi:10.1016/j.smallrumres.2005.04.029

Cited by 17 publications

(29 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sedation was probably a result of the systemic absorption of these drugs. The authors’ findings describing the sedative qualities of romifidine and detomidine in buffalo are similar to those reported in cattle and goats after epidural administration of α 2 -adrenoceptor agonists (Caron and LeBlanc 1989, Zaugg and Nussbaum 1990, Prado and others 1999, Fierheller and others 2004, Kinjavdekar and others 2006). Sedation occurs following the absorption of epidurally administered drugs into the vascular system (Gomez De Segura and others 1993, Robinson and Natalini 2002) or transfer from the cerebral spinal fluid (Pedraz and others 1991).…”

Section: Discussionsupporting

confidence: 80%

“…Conversely, a significant decrease in the respiratory rate (P<0.05) was reported in cattle and goats after epidural or subarachnoid administration of romifidine and detomidine (Prado and others 1999, Fierheller and others 2004, Kinjavdekar and others 2006). …”

Section: Discussionmentioning

confidence: 96%

“…Romifidine and detomidine are selective α 2 -adrenoceptor agonists with analgesic and systemic effects in many animal species. They have been administered epidurally or spinally in large and small ruminants (Gomez De Segura and others 1993, Prado and others 1999, Aithal and others 2001, Amarpal and others 2002, Fierheller and others 2004, Kinjavdekar and others 2006). To the authors’ knowledge, epidural analgesia in buffalo using detomidine and romifidine has not been described.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Comparative antinociceptive and sedative effects of epidural romifidine and detomidine in buffalo (Bubalus bubalis)

Marzok

El-Khodery

2017

Veterinary Record

View full text Add to dashboard Cite

In this study, comparative antinociceptive and sedative effects of epidural administration of romifidine and detomidine in buffalo were evaluated. Eighteen healthy adult buffalo, allocated randomly in three groups (two experimental and one control; n=6) received either 50 μg/kg of romifidine or detomidine diluted in sterile saline (0.9 per cent) to a final volume of 20 ml, or an equivalent volume of sterile saline epidurally. Antinociception, sedation and ataxia parameters were recorded immediately after drug administration. Epidural romifidine and detomidine produced mild to deep sedation and complete antinociception of the perineum, inguinal area and flank, and extended distally to the coronary band of the hindlimbs and cranially to the chest area. Times to onset of antinociception and sedation were significantly shorter with romifidine than with detomidine. The antinociceptive and sedative effects were significantly longer with romifidine than with detomidine. Romifidine or detomidine could be used to provide a reliable, long-lasting and cost-effective method for achieving epidural anaesthesia for standing surgical procedures in buffalo. Romifidine induces a longer antinociceptive effect and a more rapid onset than detomidine. Consequently, epidural romifidine may offer better therapeutic benefits in the management of acute postoperative pain.

show abstract

Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 99%

See 1 more Smart Citation

Comparative antinociceptive and sedative effects of epidural romifidine and detomidine in buffalo (Bubalus bubalis)

Marzok

El-Khodery

2017

Veterinary Record

View full text Add to dashboard Cite

show abstract

“…The authors’ findings describing the sedation qualities of romifidine in cows are similar to those reported for cattle and goats after epidural administration of α-2 adrenoceptor agonists (Caron and LeBlanc 1989, Zaugg and Nussbaum 1990, Prado and others 1999, Fierheller and others 2004, Kinjavdekar and others 2006). Sedation occurs following the absorption of epidurally administrated drugs into the vascular system (Gomez De Segura and others 1993, Robinson and Natalini 2002) or transfer from the cerebral spinal fluid (Pedraz and others 1991).…”

Section: Discussionsupporting

confidence: 77%

“…However, a significant decrease in the RR (P<0.05) was reported in cattle and goats after epidural or subarachnoid administration of romifidine (Aithal and others 2001, Fierheller and others 2004, Kinjavdekar and others 2006). …”

Section: Discussionmentioning

confidence: 96%

Dose‐dependent antinociceptive and sedative effects of epidural romifidine in cattle

Marzok

El-Khodery

2016

Veterinary Record

View full text Add to dashboard Cite

The objective of this study was to evaluate the antinociceptive and sedative effects of epidural administration of romifidine in dairy cattle. Twenty-four dairy cows, divided randomly into four groups (three experimental and one control; n=6) received one of three doses of romifidine (30, 40 or 50 μg/kg) diluted in sterile saline (0.9 per cent) to a final volume of 25 ml or an equivalent volume of sterile saline. Antinociception and its anatomical extent was assessed by applying a standard stimulus (needle pin pricks) in different areas and by applying an electrical stimulus to the flank. The antinociceptive effect of romifidine was produced not only in the tail, anus, perineum, vulva and inguinal area but extended up to the coronary band of the hindlimbs and chest areas. Epidural romifidine induced mild-to-moderate sedation at 30 and 40 μg/kg doses and deep sedation at the 50 μg/kg dose. The antinociceptive and sedative effect was dose-dependent in terms of intensity and duration. Thus, epidural administration of romifidine was effective in providing antinociception and sedation in cattle, and can be used in standing flank and udder surgery in cattle.

show abstract

Evaluation of haematological and biochemical changes following xylazine, tramadol and lignocaine premedicated propofol anaesthesia in West African dwarf goat

2023

View full text Add to dashboard Cite

Potential effect of romifidine with lidocaine administration in goats

Cited by 17 publications

References 32 publications

Comparative antinociceptive and sedative effects of epidural romifidine and detomidine in buffalo (Bubalus bubalis)

Comparative antinociceptive and sedative effects of epidural romifidine and detomidine in buffalo (Bubalus bubalis)

Dose‐dependent antinociceptive and sedative effects of epidural romifidine in cattle

Evaluation of haematological and biochemical changes following xylazine, tramadol and lignocaine premedicated propofol anaesthesia in West African dwarf goat

Contact Info

Product

Resources

About