Comparative antinociceptive and sedative effects of epidural romifidine and detomidine in buffalo (Bubalus bubalis)

Abstract

In this study, comparative antinociceptive and sedative effects of epidural administration of romifidine and detomidine in buffalo were evaluated. Eighteen healthy adult buffalo, allocated randomly in three groups (two experimental and one control; n=6) received either 50 μg/kg of romifidine or detomidine diluted in sterile saline (0.9 per cent) to a final volume of 20 ml, or an equivalent volume of sterile saline epidurally. Antinociception, sedation and ataxia parameters were recorded immediately after drug administration. Epidural romifidine and detomidine produced mild to deep sedation and complete antinociception of the perineum, inguinal area and flank, and extended distally to the coronary band of the hindlimbs and cranially to the chest area. Times to onset of antinociception and sedation were significantly shorter with romifidine than with detomidine. The antinociceptive and sedative effects were significantly longer with romifidine than with detomidine. Romifidine or detomidine could be used to provide a reliable, long-lasting and cost-effective method for achieving epidural anaesthesia for standing surgical procedures in buffalo. Romifidine induces a longer antinociceptive effect and a more rapid onset than detomidine. Consequently, epidural romifidine may offer better therapeutic benefits in the management of acute postoperative pain.

Comparative Efficacy of Xylazine, Detomidine and Romifidine as Epidural Anesthetics in Egyptian Goat (Capra Hircus)

“…It may be also referred to rapid vascular or lymphatic absorption from the subarachnoid space [14]. No significant difference detected in the onset of sedation between XYL and DET, while the onset of ROM was significantly delayed than both of them, this result disagreed with the published investigation of Marzok and El-khodery [15] who observed that time to onset of sedation was significantly prolonged following epidural detomidine (11.2 ±2.4 min) in comparison with epidural romifidine in buffalo (5.8±1.1 min), this variation may be attributed to species difference. The duration of sedation was significantly prolonged with XYL and ROM than DET.…”

“…Results of the present study in group 3 indicated that romifidine produced moderate to complete degree of analgesia in the region of perineum, tail, flank and hind limbs in goats at dose of 50µg/kg [8,9,17]. The duration was significantly prolonged than that produced by xylazine or detomidine in spite of delayed response to onset of analgesia for romifidine [15]. This result may be attributed to that the mechanism of analgesic action of epidurally administered romifidine, like that of other alpha-2 adrenergic agonists as well as it inhibits impulse conducting in primary afferent nerve fibers as a result of the local anesthetic action of romifidine at spinal nerve roots [8].…”

“…Epidural administration of xylazine, detomidine and romifidine resulted in analgesia due to stimulation of α-2 adrenoceptors in the dorsal horn of the spinal cord resulted in analgesia in goats. This stimulation has been reported to inhibiting the central transmission of the afferent nociceptive impulses [6] by pre- and postsynaptic membrane hyperpolarization and inhibiting the release of neurotransmitters, norepinephrine and substance-p, which is involved in pain sensation leading to reduce the neural activities and analgesia [8,14,15,16].…”

Dose-dependent effect of romifidine on intraocular pressure in clinically healthy buffalo (Bubalus bubalis)

“…Sedation is recommended for the restraint of buffalo in order to perform various types of surgery, especially when a standing position is required (Fierheller et al., 2004; Lee and Yamada, 2005; Marzok and El-khodery, 2017). In contrast, under field conditions, a general anesthesia is not appropriate for large ruminants due to the lack of facilities and high cost of the equipment (Fierheller et al., 2004; Marzok and El-khodery, 2017). Moreover, recumbency associated with general anesthesia may place great stress on the cardiovascular and pulmonary functions (Marzok and El-khodery, 2017).…”

“…In contrast, under field conditions, a general anesthesia is not appropriate for large ruminants due to the lack of facilities and high cost of the equipment (Fierheller et al., 2004; Marzok and El-khodery, 2017). Moreover, recumbency associated with general anesthesia may place great stress on the cardiovascular and pulmonary functions (Marzok and El-khodery, 2017).…”