Potential Drug-Drug Interactions in Psychiatric Ward of a Tertiary Care Hospital: Prevalence, Levels and Association with Risk Factors

Ismail, Muhammad; Iqbal, Zafar; Khattak, Muhammad Bilal; Javaid, Arshad; Khan, Muhammad Imran; Khan, Tahir Mehmood; Asim, Syed Muhammad

doi:10.4314/tjpr.v11i2.17

Cited by 36 publications

(80 citation statements)

References 18 publications

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“…Overall, 25.8 % patients were exposed to at least one pDDI regardless of severity-types, 10.75 % to at least one major pDDI, 15.25 % to at least one moderate pDDI, and 12.5 % to at least one minor pDDI. In comparison to other clinical settings, overall prevalence of pDDIs in pediatrics (25.8 %) was lower than that reported by many other studies ranging from 37 % to 50% in whole hospital settings [15,16]; 77.5 % in cardiology [7], 48 % in internal medicine [17], 58 % in oncology [8], 64.8 % in psychiatry [9], 70 % in intensive care units [10], and 45 % in pulmonology [11]. Results of the present study suggest that pDDIs are less prevalent in pediatrics ward as compared with other wards and specialties such as cardiology, internal medicine, oncology, psychiatry, intensive care units and pulmonology.…”

Section: Discussionmentioning

confidence: 61%

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Frequency, Levels and Predictors of Potential Drug-Drug Interactions in a Pediatrics Ward of a Teaching Hospital in Pakistan

Ismail¹,

Iqbal²,

Khan³

et al. 2013

Trop. J. Pharm Res

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Section: Discussionmentioning

confidence: 61%

“…Some studies have investigated pDDIs in particular clinical situations or specialties such as cardiology [7], oncology [8], psychiatry [9], intensive care units [10], pulmonology [11], and geriatrics [12]. Most of the aforementioned studies are limited to adult patients.…”

Section: Introductionmentioning

confidence: 99%

Frequency, Levels and Predictors of Potential Drug-Drug Interactions in a Pediatrics Ward of a Teaching Hospital in Pakistan

Ismail¹,

Iqbal²,

Khan³

et al. 2013

Trop. J. Pharm Res

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“…Majority of the studies investigated the possible DDIs in different specialties like general medicine, oncology, cardiology, pulmonology and psychiatry where the information is just restricted to the adult population [16][17][18][19][20][21][22][23]. Very few studies were performed in the pediatrics specialty and hence, in this study we made an attempt to study the prevalence and severity of possible drug-drug interactions in pediatrics specialty.…”

Section: Introductionmentioning

confidence: 99%

A Study on the Prevalence and Severity of Possible Drug-Drug Interactions in Pediatrics Department at an Indian Tertiary Care Teaching Hospital

Sripada

Kumar

Devanna

et al. 2018

Int J Pharm Pharm Sci

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Objective: To study the prevalence and severity of possible drug-drug interactions in the department of pediatrics. Methods:Case records of the in-patients of the pediatrics department from the medical records department were included and the records of the ambulatory patients were excluded from the study. All the collected cases were subjected to check for the drug-drug interactions by using the software micromedex 2.0 and the interactions were categorized based on the severity into minor, moderate and major.Results: A total of 142 cases were screened for possible drug-drug interactions (DDIs) and among them 76 cases were observed to be with possible DDIs. The prevalence was found to be 53.5% in this study. Majority of the cases with possible DDIs were observed to be in females. Results of the age wise categorization revealed that majority of the possible DDIS were observed in children (2-12 y) followed by the infants (1 mo-2 y). The drug combinations amikacin+ampicillin, paracetamol+phenytoin and ofloxacin+ondansetron were found to be the frequently observed possible DDIs of minor, moderate and major severities respectively. Conclusion:Majority of the possible DDIs were of moderate severity followed by major. Clinical pharmacists should take the responsibility in assisting the pediatricians for screening the possible DDIs in the prescriptions there by preventing them and providing a better pharmaceutical care for the pediatric population.

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“…Dari pengamatan diperoleh 1 kasus dengan persentase 14,3% yaitu seftriakson dengan lasix yang tergolong potensi interaksi minor, seftriakson meningkatkan toksisitas furosemid secara sinergis dengan meningkatnya risiko nefrotoksisitas [41]. Interaksi minor adanya efek kecil yang dihasilkan yang tidak menggangu hasil terapi dan tidak ada perubahan besar yang terjadi selama terapi [42].…”

Section: G2unclassified

Audit Secara Prospektif terhadap Antimicrobial Stewardship Program pada Pasien Kanker Payudara di RSUP Dr. M. Djamil Padang

et al. 2017

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Pembedahan yang digunakan sebagai bagian dari pengobatan kanker payudara memiliki potensi risiko infeksi karena pengaruh flora normal pada tubuh dan udara di lingkungan rawat inap. Keefektifan suatu antibiotik dipengaruhi oleh resistensi bakteri terhadap antibiotik. Tujuan penelitian ini untuk mengetahui pola bakteri, pola sensitifitas antibiotik dan pola penggunaan antibiotik pada pasien kanker payudara di bangsal bedah RSUP Dr. M. Djamil Padang pada bulan April - September 2017. Penelitian ini dilakukan secara prospektif menggunakan metode observasi yang bersifat deskriptif. Pola bakteri pada pasien ditemukan Staphylococcus aureus dan Klebsiella sp. sedangkan pada udara ditemukan bakteri Staphylococcus aureus, Staphylococcus epidermidis dan Klebsiella sp. Berdasarkan pola sensitifitas bakteri terhadap antibiotik selama bulan April-Mei 2017 maka yang tergolong baik (>80%) adalah amoksisilin/asam klavulanat dan meropenem sementara pada bulan Agustus-September 2017 adalah meropenem. Pola sensitifitas bakteri udara selama bulan April-Mei 2017 tidak ditemukan yang tergolong baik sedangkan pada bulan Agustus-September 2017 adalah gentamisin, siprofloksasin dan meropenem. Dari total pasien sebanyak 32 orang, yang memenuhi kriteria inklusi hanya 7 orang pasien. Pola penggunaan antibiotik terbanyak pada pasien adalah seftriakson dengan jumlah 7(77,8%) dan terjadi perubahan pola sensitifitas antibiotik seftriakson pada bulan April - Mei 2017 yaitu sensitif (66,7%) menjadi (33,3%) pada bulan Agustus-September 2017. Evaluasi kerasionalan penggunaan antibiotik, diperoleh 6(66,7%) tepat obat, 9(100%) tepat dosis, 7(77,8%) tepat lama pemberian 9(100%) tepat rute,7(100%) tepat pasien dan 4(45,1%) tepat indikasi serta potensi interaksi obat sebanyak 1(14,3%) yaitu potensi minor.

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Potential Drug-Drug Interactions in Psychiatric Ward of a Tertiary Care Hospital: Prevalence, Levels and Association with Risk Factors

Abstract: Purpose: To identify the prevalence of potential drug-drug interactions (pDDIs) in a psychiatric

Cited by 36 publications

References 18 publications

Frequency, Levels and Predictors of Potential Drug-Drug Interactions in a Pediatrics Ward of a Teaching Hospital in Pakistan

Frequency, Levels and Predictors of Potential Drug-Drug Interactions in a Pediatrics Ward of a Teaching Hospital in Pakistan

A Study on the Prevalence and Severity of Possible Drug-Drug Interactions in Pediatrics Department at an Indian Tertiary Care Teaching Hospital

Audit Secara Prospektif terhadap Antimicrobial Stewardship Program pada Pasien Kanker Payudara di RSUP Dr. M. Djamil Padang

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