Purpose: To identify the prevalence of potential drug-drug interactions (pDDIs) in a psychiatric

The present study has recorded a high prevalence of pDDIs in internal medicine wards. Patients with old age, longer hospital stay and increased number of prescribed medications were at higher risk.

Background: Despite the recommendation of zinc in the management of acute diarrhoeal illness, the effect has been seldomly reported in adolescent population. Objective: To evaluate the efficacy of zinc supplementation in acute diarrhoea in adolescent population. Study Design: Randomized Controlled Trial. Settings: Department of Medicine and Paediatrics, Hayatabad Medical Complex. Study duration: This study was conducted from 1st February 2022 till 31st October 2022. Materials and methods: Both male and female patients presenting with acute diarrhoeal illness were enrolled. Patients were equally divided through block randomization into two groups. Elemental zinc at 20mg BD was administered orally to the study group. Control group received mineral and vitamin supplementation except zinc. Efficacy was evaluated in terms of reduction in stool frequency and hospital stay. Results: Age of the patients ranged from 10 to 18 years. Mean age of the patients in study group was 14.83±3.730 years versus 13.90±3.806 years in control group. Mean stool frequency on presentation in study versus control group were 5.904±1.052 versus 6.089±1.472 respectively while on day it was 1.472±0.130 versus 2.937±640 respectively. Recovery was observed in 29 patients (93.5%) in study group as compared to 21 patients (67.7%) in control group.

The section of mammalian metabolism known as ketogenesis is responsible for creating ketone bodies. In this mechanism, the liver responds to decreased glucose availability by producing the tiny, water-soluble molecules acetoacetate, D-3-hydroxybutyrate, and propanone. While ketone bodies are always present in small amounts in healthy people, dietary changes and some pathological circumstances can raise the concentrations of these substances in living organisms. The systemic effects of ketogenic diet (KD), despite its recent widespread usage, are poorly known and can range from potentially dangerous results to medically advantageous outcomes depending on the situation. Here, we discuss the metabolism and molecular signaling of ketone bodies before relating the biology of ketone bodies to debates about their potential or actual health benefits. According to the findings of this research, a KD can be used as a natural treatment for weight loss in fat individuals. This is a one-of-a-kind research that will follow the effects of a KD for 24 weeks. The patients' lipid, total cholesterol, LDL cholesterol, and glucose levels all decreased significantly, while their HDL cholesterol levels increased significantly. The adverse effects of medications widely used for weight loss in such individuals were not noted in patients on the KD.

Objective: To estimate the frequency of thrombocytopenia among patients with vivax-positive malaria. Study Design: Cross Sectional Study. Setting: Department of General Medicine Hayatabad Medical Complex Peshawar. Period: May 2022 to November 2022. Material & Methods: Total 140 cohort were observed in this study. Patients were taken as sample according to inclusion and exclusion criteria as per operational definition after the patients' written informed consent. Sociodemographic data was collected on a predesigned questionnaire. History such as febrile illnesses and blood dyscrasias and basic studies and peripheral blood smears were obtained. Results: The results of the study showed the sample has mean age 36 years with SD ± 3.72, of which 70% were men while 30% were women. Thrombocytopenia was observed in 68% of patients. Conclusion: In conclusion, the estimated frequency of thrombocytopenia in vivax malaria was found to be 68%.