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Introduction: Medication nonadherence is the most common issue observed in the management of diabetes because of complex and lifelong therapy. The study aimed to assess the effect of pharmacist-directed counseling and daily text message reminder on medication adherence and clinical profile of patients with type II diabetes. Materials and Methods: This prospective, open-labeled, randomized control trial was carried out in outpatient medical department of a secondary care referral hospital. A total of 330 patients who met study criteria were enrolled and randomized into an intervention group ( n = 165), received counseling and daily messages about medication intake and control group ( n = 165), and usual care by physician. Medication adherence and clinical outcomes such as glycosylated hemoglobin (HbA1C), systolic blood pressure (SBP), low-density lipoprotein (LDL) cholesterol, triglyceride (TG) levels, and body mass index (BMI) were recorded at baseline and follow-up visits. Two-sample Wilcoxon rank sum test was used to compare the mean difference of medication adherence and paired t -test was used to compare clinical outcomes. Results and Discussion: The mean age of intervention and control groups were 57.1 ± 8.55 and 58.5 ± 8.53 years, respectively. The mean difference of medication adherence from baseline to second follow-up visit was significantly more in intervention group (12.2 ± 7.1%) compared to that in control group (0.75 ± 10.2 %) with a P < 0.001. From baseline to second follow-up visit, HbA1C (7.79 ± 0.67 to 6.91 ± 0.83 %), SBP (136.75 ± 20.09 to 126.23 ± 18.22 mm Hg), and LDL cholesterol (104.14 ± 26.23 to 98.29 ± 20.87 mg/dL) levels were significantly reduced in intervention group compared to that in control group with a P < 0.01. No significant improvement was observed in TG (169± 33.71 to 168 65 ± 33.90 mg/dL) and BMI (27.9 ± 4.21 to 27.1 ± 3.12 Kg/m 2 ) levels from baseline to second follow-up visit. Conclusion: Pharmacist-directed patient counseling combined with message reminder showed a greater effect on the improvement of medication adherence and control of glycemia, blood pressure, and lipid profile in diabetes.

An ethno-medicinal investigation was conducted to highlights the traditional knowledge of medicinal plants being used by the tribe in West and South district of Tripura. This paper provides information about the different uses of plants used in their primary health care system. Tripura is a small north-eastern state of India and also a part of both Himalayan and Indo-Burma biodiversity region. It is a goldmine of medicinal plants and use of different plants in tribal traditional heath care systems has long history. Nineteen different tribes in Tripura, depend on natural resources at a great extent. This paper documented 113 medicinal plant species from 56 families along with their botanical name, local name, family name, habit, medicinal parts used, and traditional usage of application. The dominant families are Euphorbiaceae (7 species), Apocynaceae (6 species), Fabaceae and Rubiaceae (5 species each), Caesalpiniaceae, Asteraceae, Liliaceae and Verbenaceae (4 species each), Combretaceae, Labiatae, Malvaceae, Rutaceae and Zingiberaceae (3 species each). Tribes of Tripura have rich traditional knowledge on plant based medicine. Different parts of the plants in crude form/plant extracts/decoctions/infusion or pastes are employed in diverse veterinary and human diseases by the tribe's of Tripura in daily life.

Background:Data about the health-related quality of life (HR-QOL) of people living with HIV/AIDS (PLHA) after the implementation of free antiretroviral treatment in India are scarce.Aim:The study was to describe the HR-QOL and gender differences of PLHA in rural India.Materials and Methods:Cross sectional study of 120 PLHA who came to the outpatient department in a rural district hospital. Assessment of the HR-QOL was performed through interviews using a validated structured questionnaire from the Medical Outcome Study HIV Health Survey. Linear regression with robust standard errors was used for multivariable analysis.Results:Domains related to social and daily activities such as cognitive, role and social functioning had lower HR-QOL scores than domains related to physical health. Men had higher scores of HR-QOL in health transition, perceived HR-QOL, health distress, social functioning and role functioning. In multivariable analysis, factors associated with poorer HR-QOL were female sex, lower levels of education and being widowed or separated in women.Conclusions:HR-QOL of PLHA in rural India is poor, especially in widowed or separated women and people with lower levels of education. There is an urgent need of implementing programmes for improving the HR-QOL of HIV infected women in rural India.

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Bu çalışmanın amacı tiyokolşikosid için en iyi poloksamer katı dispersiyon taşıyıcısını bulmaktır. Gereç ve Yöntemler: Tiyokolşikosidin eksipiyanlarla geçimliliği diferansiyel tarama kolorimetrisi ve fourier transform infrared spektroskopisi ile çalışılmıştır. Katı dispersiyonların (SD) farklı formülasyonları poloksamer-108, poloksamer-188, poloksamer-237, poloksamer-338 ve poloksamer-407 gibi poloksamer taşıyıcılarını tiyokolşikosid: poloksamer oranı 1:1, 1:2, 1:4 ve 1:6 olacak şekilde yapılmıştır. SD'ler yeni bir mikrodalga füzyon metoduyla yapılmıştır ve 8-istasyonlu tablet kompresyon makinesi kullanılarak basılmıştır. Üretilen SD tabletleri fizikokimyasal kısıtlama ve ilaç salım oranları ile karakterize edilmiştir. Hazırlanan SD'lerden salınan tiyokolşikosid daha sonra kinetik modellerle analiz edilmiştir. Bulgular: Tiyokolşikosid poloksamer taşıyıcılarla geçimli bulunmuştur. SD formülasyonları fizikokimyasal kısıtlamalar açısından ve tek basamaklı salımı takiben tatmin eden tiyokolşikosid salmı göstermiştir. Sonuç: Kullanılan poloksamer taşıyıcılar arasında, poloksamer-188 çözünürlük artışı ve SD'lerde tiyokolşikosid salımı açısından en iyisi olarak belirlenmiştir.