Total phenolic, total flavonoid content, and antioxidant capacity of the leaves of Meyna spinosa Roxb., an Indian medicinal plant

Sen, Saikat; De, Biplab; Devanna, N.; Chakraborty, Raja

doi:10.1016/s1875-5364(13)60042-4

Cited by 77 publications

(73 citation statements)

References 19 publications

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“…In summary, an high-fat diet caused heperlipidemic and oxidative injury occurred in mice fed with high-fat diet, as did elevate variety of indexes and oxidative stress in liver and adipose tissues. Our result in accordance with the recently study that extracts of the leaves of Meyna spinosa contain high levels of flavonoids, and possess significant antioxidant activities [23]. Arora et al (1998) found that flavonoids displayed higher antioxidant capacity against metal-ion-induced peroxidation than peroxyl-radical-induced peroxidation [24].…”

Section: Discussionsupporting

confidence: 92%

Research on Anti-oxidant Activity and Hypolipemic Mechanism of Aloes Flavonoids in Mice

Li¹,

Kehui²,

Jiaoying³

et al. 2014

JFNR

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Aloe flavonoids exhibit various biological activities. The aim of this study was conducted to evaluate antioxidant activity and the hypolipemic mechanism of aloe flavonoids in mice. 80 hyperlipidemic mice were divided into 5 groups, each group was oral administrated with water, 4 mg/kg·BW simvastatin, 100, 200, 300 mg/kg·BW aloe flavonoids per day, respectively. Meanwhile, 16 normal mice were used as blank control, and oral administrated with water per day. After 8 weeks intervention, the concentrations of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL), total antioxidant capacity (T-AOC) and glutathione peroxidase (GSH-Px) in the adipose and liver tissues were evaluated. Also, hormone-sensitive lipase (HSL), peroxisome proliferator-actived receptor gamma (PPAR-γ), adipose triacylglyceride lipase (ATGL), and fatty acid synthase (FAS) genes expressions in the two tissues were detected by Q-PCR. The results showed that aloe flavonoids could decrease the TC, TG levels in the adipose and liver, while the levels of T-AOC, CAT, GSH-Px were significanly increased when compared to the control group. After treating with aloe flavonoids, the gene expressions of HSL, PPARγ and ATGL expression enhanced, but the gene expression of FAS decreased when compared to the control group. In conclusion, our data showed that aloe flavonoids have potent hypolipemic and antioxidant activities.

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Section: Discussionsupporting

confidence: 92%

Research on Anti-oxidant Activity and Hypolipemic Mechanism of Aloes Flavonoids in Mice

Li¹,

Kehui²,

Jiaoying³

et al. 2014

JFNR

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“…H 2 O 2 is a potent non-free radical species, able to cross cell membranes, and oxidize a number of cell compounds originating many of its toxic effects (Gulcin et al, 2006). Therefore, the extracts that are able to eliminate hydrogen peroxide may be significant for human health and have the potential to be used to protect pharmaceutical and food system (Sen et al, 2013). Concerning the scavenging capacity of V. cauliflora against H 2 O 2 , the flower extract was more effective than all other parts and also showed higher efficiency than standards of gallic acid, quercetin, ascorbic acid (Table 3), ellagic acid (108.3 mg/mL) , Juglans regia leaf extracts (383 mg/mL) (Almeida et al, 2008b), and Meyna spinosa leaf extracts, a traditional medicinal plant from India (126.8 mg/mL) (Sen et al, 2013).…”

Section: Scavenging Of Ros and Rns By Vismia Cauliflora Extractsmentioning

confidence: 99%

“…Therefore, the extracts that are able to eliminate hydrogen peroxide may be significant for human health and have the potential to be used to protect pharmaceutical and food system (Sen et al, 2013). Concerning the scavenging capacity of V. cauliflora against H 2 O 2 , the flower extract was more effective than all other parts and also showed higher efficiency than standards of gallic acid, quercetin, ascorbic acid (Table 3), ellagic acid (108.3 mg/mL) , Juglans regia leaf extracts (383 mg/mL) (Almeida et al, 2008b), and Meyna spinosa leaf extracts, a traditional medicinal plant from India (126.8 mg/mL) (Sen et al, 2013). In general, the IC 50 values to scavenge H 2 O 2 are higher in comparison with other ROS and RNS and sometimes the IC 50 could be not achieved in the maximum concentration tested Sen et al, 2013).…”

Section: Scavenging Of Ros and Rns By Vismia Cauliflora Extractsmentioning

confidence: 99%

Bioactive compounds and scavenging capacity of extracts from different parts ofVismia caulifloraagainst reactive oxygen and nitrogen species

Ribeiro¹,

Berto

Chisté

et al. 2015

Pharmaceutical Biology

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Context: Vismia cauliflora A.C.Sm. [Hypericaceae (Clusiaceae)] is a plant from Amazonian forest. It is used by Amerindians to treat dermatosis and inflammatory processes in the skin and has been considered an interesting source of bioactive compounds. Objective: We evaluated the scavenging capacity of extracts from V. cauliflora (leaf, branch, stem bark, flower, and whole fruit) against reactive oxygen (ROS) and nitrogen species (RNS), namely, superoxide radical (O . The identification and the quantification of phenolic compounds and carotenoids were carried out by HPLC-DAD-ESI-MS/MS and HPLC-DAD, respectively. Results: (À)-Epicatechin and proanthocyanidin dimers and trimer were the major phenolic compounds tentatively identified in leaf, branch, stem bark, and flower extracts, while dihydroxybenzoic acids were the major compounds in whole fruit extracts. All-trans-zeinoxanthin and all-trans-b-carotene were the major carotenoids tentatively identified in leaf extracts. All extracts of V. cauliflora showed high efficiency against all tested ROS and RNS, although flower and stem bark extracts exhibited the most remarkable scavenging capacity, especially for NO and ONOO À . Discussion and conclusion: Vismia cauliflora has great potential to be used in the development of phytopharmaceutical products due to its characteristic of being a promising source of bioactive compounds with high antioxidant properties.

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“…Normally there is a balance between the amount of free radicals generated in the body and the antioxidant defense systems that scavenge/quench these free radicals preventing them from causing deleterious effects in the body, but increased load of free radicals in body, either due to environmental condition or produced within the body, results in oxidative stress, which may result in tissue injury and subsequent diseases. 29,30 The study demonstrated that the Laghupanchamula formulation containing Eranda possessed more efficient antioxidant potential as compared with formulation containing Gokshura. Antioxidant phytoconstituents from medicinal plants have competence to abide oxidative stress by their ability to scavenge free radicals, impeding lipid peroxidation and various alternative methods.…”

Section: Discussionmentioning

confidence: 94%

Comparative Study on Two Variants of Laghupanchamula (A Compound Ayurvedic Formulation) for Important Groups of Phytochemicals and Antioxidant Activity

Ghildiyal¹,

Joshi²,

Joshi³

2017

Journal of Drug Research in Ayurvedic Sciences

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Introduction: Laghupanchamula is a compound formulation prepared by combinations of roots of five herbs. Two variants of Laghupanchamula have been described in Ayurvedic classics where beside four common herbs fifth one is either Gokshura (Tribulus terrestris L.) or Eranda (Ricinus communis L.). The objective of the study is to make comparison between two variants of Laghupanchmula with respect to important group of phytochemicals and antioxidant activity to corroborate the science behind their therapeutic utility.

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Total phenolic, total flavonoid content, and antioxidant capacity of the leaves of Meyna spinosa Roxb., an Indian medicinal plant

Cited by 77 publications

References 19 publications

Research on Anti-oxidant Activity and Hypolipemic Mechanism of Aloes Flavonoids in Mice

Research on Anti-oxidant Activity and Hypolipemic Mechanism of Aloes Flavonoids in Mice

Bioactive compounds and scavenging capacity of extracts from different parts ofVismia caulifloraagainst reactive oxygen and nitrogen species

Comparative Study on Two Variants of Laghupanchamula (A Compound Ayurvedic Formulation) for Important Groups of Phytochemicals and Antioxidant Activity

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