Possible Correlation between Borna Disease Virus Infection and Japanese Patients with Chronic Fatigue Syndrome

Kitani, Teruo; Kuratsune, Hirohiko; Fuke, Isao; Nakamura, Y.; Nakaya, Takaaki; Asahi, Sayumi; Tobiume, Minoru; Yamaguti, Kouzi; Machii, Takashi; Inagi, Reiko; Yamanishi, Koichi; Ikuta, Kazuyoshi

doi:10.1111/j.1348-0421.1996.tb01094.x

Cited by 52 publications

(22 citation statements)

References 13 publications

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“…The elevation of antibodies to various viruses is thought to be caused by a nonspecific polyclonal B-lymphocytic response (16). However, the elevated levels of antibodies to BDV identified in our previous studies (25,31) and this study ( Fig. 1) might be unrelated to this nonspecific response, because there was no correlation among the antibody titers to BDV and EBV (Fig.…”

Section: Discussioncontrasting

confidence: 49%

“…1) might be unrelated to this nonspecific response, because there was no correlation among the antibody titers to BDV and EBV (Fig. 2) as well as BDV, HHV-6 or EBV (25) . The sequences of the p24 RT-PCR products from all the family #1 members and family #2 mother were very similar (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…The notion that BDV is associated with psychiatric disorders or CFS is based on the high prevalence of anti-BDV antibodies (4-7, 24, 25, 31, 33, 35, 36) or BDV RNA in PBMCs (7,22,24,25,31,36) as cornpared to healthy or blood donor controls (23,25,36). BDV infection has been determined in two families with psychiatric disorders by serological assays (3).…”

Section: Discussionmentioning

confidence: 99%

“…Further, Kitani et al (25) showed that BDV antibodies were positive in 33.7% (30/89) of Japanese CFS patients and only in 3 of 100 healthy controls, whereas BDV RNA in PBMCs was detected in 12.3% (7/57) of patients and only 4.7% (8/172) of healthy controls. A similar BDV seroprevalence was shown in Swedish CFS patients (28) and CFS patients in the UK (13).…”

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confidence: 99%

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Borna Disease Virus Infection in Two Family Clusters of Patients with Chronic Fatigue Syndrome

Nakaya

Takahashi

Nakamura

et al. 1999

Microbiology and Immunology

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A high rate of Borna disease virus (BDV) infection has been demonstrated in patients with chronic fatigue syndrome (CFS). Herein, we focused on BDV infection in two family clusters of patients with CFS: a father, mother, two sons and one daughter (family #1); and a father, mother, two daughters and one son (family #2), All members, except for the elder son in family #1 and the father and son in family #2, were diagnosed with CFS. The results supported that all the family members with CFS were infected with BDV, as evidenced by the presence of antibodies to viral p40, p24 and/or gp18 and BDV p24 RNA in peripheral blood mononuclear cells. The healthy members, except for the father of family #2 who was positive for antibody to p24, were all negative by both assays. Follow-up studies in family #1 continued to reveal BDV antibodies and BDV RNA, except in the mother, who lost the RNA upon slight recovery from the disease.

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Section: Discussioncontrasting

confidence: 49%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Borna Disease Virus Infection in Two Family Clusters of Patients with Chronic Fatigue Syndrome

Nakaya

Takahashi

Nakamura

et al. 1999

Microbiology and Immunology

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“…A wide spectrum of viruses has been proposed as factors or cofactors in pathogenesis of CFS including enteroviruses, Epstein-Barr virus, cytomegalovirus, human herpesvirus type 6, varicella zoster virus, retroviruses and Borna disease virus (Bode et al, 1992;Buchwald et al, 1996;Kitani et al, 1996;Nakaya et al, 1996). Bode and coworkers examined sera from 50 North American CFS patients and found no evidence of BDV infection (Bode et al, 1992).…”

Section: Introductionmentioning

confidence: 99%

Absence of evidence of Borna disease virus infection in Swedish patients with Chronic Fatigue Syndrome

Evengård¹,

Briese²,

Lindh³

et al. 1999

J Neurovirol

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Chronic Fatigue Syndrome (CFS) is characterized by debilitating fatigue, somatic symptoms and cognitive impairment. An infectious basis has been proposed; candidate agents include enteroviruses, herpesviruses, retroviruses and Borna disease virus (BDV), a novel neurotropic virus associated with neuropsychiatric disorders. Sera and peripheral blood mononuclear cells (PBMC) from Swedish CFS patients were assayed for evidence of infection using ELISA and Western immunoblot for detection of antibodies to BDV proteins N, P and gp18; and using nested reverse transcriptase polymerase chain reaction (RT ± PCR) for detection of BDV N-and P-gene transcripts. No speci®c immunoreactivity to BDV proteins was found in sera from 169 patients or 62 controls. No BDV N-or P-gene transcripts were found through RT ± PCR analysis of PBMC from 18 patients with severe CFS. These results do not support a role for BDV in pathogenesis of CFS.

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Higher prevalence of Borna disease virus infection in blood donors living near thoroughbred horse farms

et al. 1997

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It is believed that Borna disease virus (BDV), an etiological agent of progressive polioencephalomyelitis in horses and sheep, is closely associated with psychiatric disorders in humans since the prevalence of BDV is higher in psychiatric patients than in blood donors. We investigated whether or not BDVs in humans are derived from infected domestic animals, by characterizing the BDVs in blood donors and horses derived from the same region of Hokkaido island, Japan. The seroprevalences (2.6 to 14.8%) of BDV were significantly higher in the blood donors from four regions where most horse farms are concentrated, compared with only 1% in the blood donors from Sapporo, the largest city in Hokkaido.BDV RNA was also detected in peripheral blood mononuclear cells from most of the seropositive horses and blood donors by nested reverse transcriptase-polymerase chain reaction. These findings support that BDV may be horizontally transmitted, at least in part, from infected horses to humans.

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Possible Correlation between Borna Disease Virus Infection and Japanese Patients with Chronic Fatigue Syndrome

Cited by 52 publications

References 13 publications

Borna Disease Virus Infection in Two Family Clusters of Patients with Chronic Fatigue Syndrome

Borna Disease Virus Infection in Two Family Clusters of Patients with Chronic Fatigue Syndrome

Absence of evidence of Borna disease virus infection in Swedish patients with Chronic Fatigue Syndrome

Higher prevalence of Borna disease virus infection in blood donors living near thoroughbred horse farms

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