Higher prevalence of Borna disease virus infection in blood donors living near thoroughbred horse farms

Takahashi, Hirokazu; Nakaya, Takaaki; Nakamura, Y.; Asahi, Sayumi; Onishi, Yoshiko; Ikebuchi, Kenji; Takahashi, Tsuneo; Katoh, Takanori; Sekiguchi, Sadayoshi; Takazawa, Masayuki; Tanaka, Hisatoshi; Ikuta, Kazuyoshi

doi:10.1002/(sici)1096-9071(199707)52:3<330::aid-jmv16>3.0.co;2-m

Cited by 45 publications

(27 citation statements)

References 24 publications

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“…Some studies described higher BDV positivity in humans who were in contact with infected animals; this BDV positivity was positively correlated with the degree of contact with infected animals. These findings proved the animal-to human transmission of BDV infection, which is typical of zoonotic infections (Takahashi et al, 1997;Thomas et al, 2005;Weismann et al, 1994). Infected rodents and wild birds are considered to be reservoirs of BDV infection (Berg et al, 2001), but pets and farm animals represent a greater risk of human BDV infection because of the closer contact with them.…”

Section: The Transmission Of Bdv Infectionsupporting

confidence: 54%

Borna Disease Virus and Psychiatric Disorders: Can Viruses Influence Psychiatric Disorders?

Racková¹,

Janů²

2011

Psychiatric Disorders - Worldwide Advances

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Section: The Transmission Of Bdv Infectionsupporting

confidence: 54%

Borna Disease Virus and Psychiatric Disorders: Can Viruses Influence Psychiatric Disorders?

Racková¹,

Janů²

2011

Psychiatric Disorders - Worldwide Advances

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“…This finding in our study is comparable to the data from Takahashi et al 28 and Weisman et al, 29 who found a higher BDV seropositive rate in people living in the neighborhood of horse farms, and in workers exposed to BDV infected animals, respectively. These results suggested not only the possible animal-to-human transmission of BDV, but also the likely human-to-human transmission of BDV as indicated in our study.…”

Section: Discussionmentioning

confidence: 99%

“…27 Takahashi et al reported higher seroprevalence of BDV infection in blood donors living near thoroughbred horse farms in Hokkaido, Japan. 28 A similar high seropositive rate of BDV infection has been observed among veterinarians, laboratory technicians, and farm workers who were exposed to BDV-infected ostriches in Israel. 29 These studies indicate the possible animalto-human transmission of BDV.…”

Section: Introductionmentioning

confidence: 99%

High seroprevalence of Borna virus infection in schizophrenic patients, family members and mental health workers in Taiwan

Chen

Yl²,

Fc³

et al. 1999

Mol Psychiatry

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Borna disease virus (BDV), a negative-strand RNA virus, has been reported to be associated with severe psychiatric disorders. The association is mainly based on the findings that patients with schizophrenia and depression have a higher seroprevalence rate of BDV-specific antibodies than controls. In addition, psychiatric patients were also found to have a higher detection rate of BDV transcripts in their blood than controls. By using an improved Western blot analysis, we first demonstrated that Chinese schizophrenic patients from Taiwan also have a higher seroprevalence of BDV-specific antibodies than controls (12.1% vs 2.9%, P Ͻ 0.001), providing support to the positive association between BDV and psychiatric disorders in our population. Because of the contagious nature of viral infection, we further examined patients' family members and mental health workers, who have close contact with patients. We found that both groups also have a higher seroprevalence of BDV-specific antibodies, 12.1% and 9.8%, respectively, than controls. This finding provides some evidence for a possible human-to-human transmission of Borna disease virus. Our finding needs further independent verification from other research groups and the clinical relevance of this preliminary observation deserves further study.

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“…Sporadic outbreaks of Borna disease have been reported in Germany [8]. There are several serological surveys from horses without giving rise to clinical signs in the Netherlands, and other European countries [8], the USA [7], Iran [2] and Japan [15], suggesting that the virus is more widely distributed than previously thought. In this paper, although we could not find any positive relationship between the detection of anti-BDV antibodies and the diseases such as neurological disorders in cats, we added Philippines and Indonesia as BDV-distributed countries.…”

mentioning

confidence: 99%

Detection of Anti-Borna Disease Virus Antibodies from Cats in Asian Countries, Japan, Philippines and Indonesia Using Electrochemiluminescence Immunoassay.

Horii¹,

Garcia

Noviana

et al. 2001

The Journal of Veterinary Medical Science

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ABSTRACT. Anti-Borna disease virus (BDV) antibodies were detected from cats in Japan, Philippines and Indonesia by using electrochemiluminescence immunoassay. Positive rates were 3.1%, 3.8% and 2.0% in Japan, Philippines and Indonesia, respectively. There was no differences in the positive rate of anti-BDV antibodies between male and female cats and among habitats. While, a significantly (P<0.05) higher prevalence (6.5%) was found in the oldest age group (more than 6 years) cats. KEY WORDS: Borna disease virus (BDV), electrochemiluminescence immunoassay (ECLIA), feline.J. Vet. Med. Sci. 63(8): 921-923, 2001 Borna disease is an infectious neurological disease that occurs sporadically in horses and sheep in Central Europe. Borna disease virus (BDV) is a noncytolytic, neurotropic, single strand, negative sense RNA virus that naturally infects a wide range of vertebrate species from birds and rodents to primates [1,3]. BDV can also cause encephalomyelitis in a wide range of experimental animals [5,6,14].In domestic cats, an characteristic disease of the central nervous system has been observed in Sweden [9]; the dominating clinical sign is an unsteady (staggering) gait. Histopathological examination of the cats showed that the inflammatory reaction of the central nervous system was most pronounced in the grey matter of the brain stem, basal ganglia and hippocampus. These changes and laboratory findings including leukopenia and elevations in protein content and white blood cell count of the cerebrospinal fluid in affected cats suggested that staggering disease is infectious and most probably caused by virus. By using an indirect immunofluorescence assay (IFA), anti-BDV antibody has been detected in the cats with typical staggering disease [10,13]. Recently, the high prevalence of BDV infections has been demonstrated in domestic cats with neurological disorders in Japan [11].A seroepidemiological survey of the cat has been done by using IFA and/or Western blot (WB) analysis also in Japan [12]. Since the antibody titers were usually very low in Borna disease, an establishment of sensitive and reliable method to detect a small amount of anti-BDV antibodies is required. Recently, we have developed a new system, electrochemiluminescence immunoassay (ECLIA), using recombinant BDV p24 and p40 proteins, which has the sensitivity and specificity to serve as a serological screening method for measuring anti-BDV antibodies [16]. In this study we tried to detect anti-BDV antibodies of domestic cats in Asian countries and to compare the prevalence of BDV among the countries.Blood samples were collected from domestic cats at veterinary hospitals of University of Philippines Los Baños, Laguna, Philippines; Faculty of Veterinary Science, Bogor Agricultural University, Bogor, Indonesia; Osaka, Kitakyushu, Kumamoto and Nagasaki, Japan. Serum samples were stored at -30°C until use.To measure antibody against BDV, ECLIA is performed as previously described [16]. Briefly, micro beads were coated with horse-derived BDV p24 and p40 reco...

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Higher prevalence of Borna disease virus infection in blood donors living near thoroughbred horse farms

Cited by 45 publications

References 24 publications

Borna Disease Virus and Psychiatric Disorders: Can Viruses Influence Psychiatric Disorders?

Borna Disease Virus and Psychiatric Disorders: Can Viruses Influence Psychiatric Disorders?

High seroprevalence of Borna virus infection in schizophrenic patients, family members and mental health workers in Taiwan

Detection of Anti-Borna Disease Virus Antibodies from Cats in Asian Countries, Japan, Philippines and Indonesia Using Electrochemiluminescence Immunoassay.

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