Borna Disease Virus Infection in Two Family Clusters of Patients with Chronic Fatigue Syndrome

Nakaya, Takaaki; Takahashi, Hirokazu; Nakamura, Y.; Kuratsune, Hirohiko; Kitani, Teruo; Machii, Takashi; Yamanishi, Koichi; Ikuta, Kazuyoshi

doi:10.1111/j.1348-0421.1999.tb02456.x

Cited by 27 publications

(9 citation statements)

References 43 publications

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“…However, in a classical example of the pitfalls of PCR diagnostics, particularly using nesting methods, BDV was implicated in a wide variety of disorders that included major depressive disorder, bipolar disorder, schizophrenia, chronic fatigue syndrome (CFS), AIDS encephalopathy, multiple sclerosis, motor neuron disease, and brain tumors (glioblastoma multiforme) (75). Following a report of BDV RNA in the blood of more than 50% of CFS subjects, which raised concerns for blood product safety (87,88), we were recruited to pursue a replication study. We found no BDV nucleic acid or specific immunoreactivity in a blinded analysis of well-characterized CFS subjects.…”

Section: Molecular Characterization Of Borna Disease Virus a Novel Nmentioning

confidence: 99%

Microbe Hunting

Lipkin

2010

Microbiol Mol Biol Rev

103

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SUMMARY Platforms for pathogen discovery have improved since the days of Koch and Pasteur; nonetheless, the challenges of proving causation are at least as daunting as they were in the late 1800s. Although we will almost certainly continue to accumulate low-hanging fruit, where simple relationships will be found between the presence of a cultivatable agent and a disease, these successes will be increasingly infrequent. The future of the field rests instead in our ability to follow footprints of infectious agents that cannot be characterized using classical microbiological techniques and to develop the laboratory and computational infrastructure required to dissect complex host-microbe interactions. I have tried to refine the criteria used by Koch and successors to prove linkage to disease. These refinements are working constructs that will continue to evolve in light of new technologies, new models, and new insights. What will endure is the excitement of the chase. Happy hunting!

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Section: Molecular Characterization Of Borna Disease Virus a Novel Nmentioning

confidence: 99%

Microbe Hunting

Lipkin

2010

Microbiol Mol Biol Rev

103

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“…In the past decade, BDV RNA, BDV proteins, anti-BDV antibody, and/or infectious virus have been found in the blood, CSF, and/or brains of patients with chronic fatigue syndrome (83,97,98) (46), and patients with various psychiatric disorders (150).…”

Section: Evidence For Bdv-induced Disease In Humans: Possible Clinicamentioning

confidence: 99%

Borna Disease Virus and Human Disease

Carbone¹

2001

Clin Microbiol Rev

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The biology of Borna disease virus (BDV) strongly supports the likelihood of human infection with BDV or a variant of BDV. Thus far, the evidence supporting BDV infection in humans has initiated much controversy among basic and clinical scientists; only time and additional research will support or refute the hypothesis of human BDV infection. Until an assay of acceptable specificity and sensitivity has been developed, validated, and used to document human BDV infection, scientists cannot reasonably begin to associate BDV infection with specific disease syndromes. Clinical studies seeking causal associations between BDV infection and specific diseases must ensure the proper identification of the BDV infection status of patients and control subjects by using a validated, highly sensitive, and highly specific assay (or series of assays). For clinical studies, a highly sensitive “screening” test followed by a highly specific confirmatory test will be of significant benefit. Although it is possible to formulate hypotheses about the clinical outcomes of human BDV infection based on animal model work, to date no human disease has been causally linked to human BDV infection. Scientists all over the world are actively pursuing these issues, and with continuing advances in clinical and basic BDV research, the answers cannot be far away

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“…In a Japanese study by Nakaya et al the prevalence of BDV p24RNA and antibody in Peripheral Blood Mononuclear Cells (PBMCs) and serum of patients with CFS was 32%, supporting the association between BDV and CFS (19). Some studies suggested a strong association in some cases of CFS (20,21).…”

Section: Contextmentioning

confidence: 94%

The Association Between Borna Disease Virus and Chronic Fatigue Syndrome: A Systematic Review and Meta-Analysis

Azami

Mojarad

Mansouri

et al. 2017

Iran J Psychiatry Behav Sci

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Context: Several studies have controversial results regarding the association between Borna disease virus (BDV) and chronic fatigue syndrome (CFS). The present systematic review and meta-analysis investigated the association between CFS and BDV. Evidence Acquisition: The present study was conducted based on the PRISMA guidelines for systematic review and meta-analysis studies. To avoid bias, all procedures of the study were performed by two researchers independently. A comprehensive search was performed using online databases, including PubMed, Scopus, Embase, PsycINFO, science Direct, Cochrane Library, web of science, and Google scholar using the MeSH keywords until December 12 th , 2016. Heterogeneity among studies was evaluated using 20 (1.66, 89.57) and 8.20 (3.32, 20.22), respectively (test for subgroup differences: P=0.72; I 2 =0). Conclusions:This study supports the association between BDV and CFS and shows the role of viral agents in etiology of CFS. Therefore, viral agents may play a role in the etiology of neuropsychiatric disorders.

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Borna Disease Virus Infection in Two Family Clusters of Patients with Chronic Fatigue Syndrome

Cited by 27 publications

References 43 publications

Microbe Hunting

Microbe Hunting

Borna Disease Virus and Human Disease

The Association Between Borna Disease Virus and Chronic Fatigue Syndrome: A Systematic Review and Meta-Analysis

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