The results of this review indicate a high seroprevalence of T. gondii (about one-third) in Iranian blood donors and emphasizes the importance of screening the seroprevalence of T. gondii of donated blood in Iranian Blood Transfusion Organization.

Context: Several studies have controversial results regarding the association between Borna disease virus (BDV) and chronic fatigue syndrome (CFS). The present systematic review and meta-analysis investigated the association between CFS and BDV. Evidence Acquisition: The present study was conducted based on the PRISMA guidelines for systematic review and meta-analysis studies. To avoid bias, all procedures of the study were performed by two researchers independently. A comprehensive search was performed using online databases, including PubMed, Scopus, Embase, PsycINFO, science Direct, Cochrane Library, web of science, and Google scholar using the MeSH keywords until December 12 th , 2016. Heterogeneity among studies was evaluated using 20 (1.66, 89.57) and 8.20 (3.32, 20.22), respectively (test for subgroup differences: P=0.72; I 2 =0). Conclusions:This study supports the association between BDV and CFS and shows the role of viral agents in etiology of CFS. Therefore, viral agents may play a role in the etiology of neuropsychiatric disorders.

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Context: Recent studies on patients with psychiatric disorders suggest a possible association between borna disease virus (BDV) and mood disorders. However, a clear association remains controversial. The current systematic review and meta-analysis study aimed at investigating the association between BDV infection and mood disorders. Methods: The current study was conducted based on preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. To obtain the evidence, several databases were searched including PubMed, Scopus, ScienceDirect, Web of Science, Embase, Cochrane Library, PsycINFO, and Google Scholar search engine without time limit until 2017. Heterogeneity of the studies was assessed using Q test and I 2 index. A random effect model was used to estimate the odds ratio (OR) with 95% confidence interval (CI). Results: Meta-analysis of 23 studies comprising 3628 cases and 5,810 controls showed that BDV infection was associated with a significantly increased risk of mood disorders (OR = 1.61; 95%CI: 1.21-2.15, P = 0.001, I 2 = 44%). Subgroup analysis was used according to diagnostic method indicating OR was 1.01 (95%CI: 0.37-2.8) for immunofluorescence antibody (IFA), 1.26 (95%CI: 0.5-3.18) for western blot (WB) assay, 1.58 (95%CI: 1.06-2.38) for real-time polymerase chain reaction (RT-PCR), 1.16 (95%CI: 0.24-5.70) for radioligand assay (RLA), 2.55 (95%CI: 1.67-3.88) for enzyme immunoassay (EIA), 2.15 (95%CI: 0.68-6.80) for enzyme-linked immunosorbent assay (ELISA), 3.29 (95%CI: 1.35-7.98) for electrochemiluminescence immunoassay (ECLIA), 4.00 (95%CI: 0.89-17.87) for peptide array, and 1.00 (95%CI: 0.23-4.27) for proliferation assay method. In subgroup analysis of bipolar and unipolar disorder, OR was 1.99 (95%CI: 1.29-3.08, P = 0.002) and 1.16 (95%CI: 0.76-1.76, P = 0.481), respectively. Conclusions: These results can confirm the significant role of BDV infection in mood disorders. Therefore, it might be necessary to consider BDV infection to manage psychiatric disorders.