The Association Between Borna Disease Virus and Chronic Fatigue Syndrome: A Systematic Review and Meta-Analysis

Abstract

Context: Several studies have controversial results regarding the association between Borna disease virus (BDV) and chronic fatigue syndrome (CFS). The present systematic review and meta-analysis investigated the association between CFS and BDV. Evidence Acquisition: The present study was conducted based on the PRISMA guidelines for systematic review and meta-analysis studies. To avoid bias, all procedures of the study were performed by two researchers independently. A comprehensive search was performed using online databases, including PubMed, Scopus, Embase, PsycINFO, science Direct, Cochrane Library, web of science, and Google scholar using the MeSH keywords until December 12 th , 2016. Heterogeneity among studies was evaluated using 20 (1.66, 89.57) and 8.20 (3.32, 20.22), respectively (test for subgroup differences: P=0.72; I 2 =0). Conclusions:This study supports the association between BDV and CFS and shows the role of viral agents in etiology of CFS. Therefore, viral agents may play a role in the etiology of neuropsychiatric disorders.

The Prevalence of Depression in Pregnant Iranian Women: A Systematic Review and Meta-Analysis

“…Systematic reviews and metaanalyses can provide a complete view of a problem in the community by examining all relevant documentation and provide a clear picture (49)(50)(51). Given the importance of depression during pregnancy, this study aimed to investigate the prevalence of depression among pregnant women in Iran using the meta-analysis method.…”

The Association Between Borna Disease Virus and Mood Disorders: A Systematic Review and Meta-Analysis

“…Evidence of the association between BDV infection and psychiatric disorders was observed in the study by Azami et al By analyzing 35 studies, significant association was confirmed between BDV infection and schizophrenia, and the estimated OR was 2.72 (95%CI: 1.75 -4.20) (25). In another meta-analysis conducted in 2017 on 9 studies, a significant association was observed between BDV infection and chronic fatigue syndrome, and the estimated OR was 10.41 (95%CI: 4.24 -25.55, P < 0.0001) (26). In addition, significant association was noted between BDV infection and depression in a meta-analysis by Wang et al (27).…”