Abstract:The polymorphism of the bovine growth hormone gene (bGH) was studied in 211 Nellore pure breed males for association with reproductive traits. Scrotal circumference and testosterone concentrations were collected monthly from 10 until 16 months of age. Additionally, testicular growth rates were calculated. DNA was amplified by PCR and digested using Msp I and Hae III restriction enzymes. Every polymorphism presented two alleles. The predominant alleles were D (0.85) and F (0.98), respectively, and genotype EE -… Show more
“…Some of them include the bovine growth hormone (bGH), associated with carcass fat content and muscle yield, milk yield, and testicular development (Yao et al, 1996;Unanian et al, 2002); the receptor of bGH, associated with a large number of productive traits such as milk yield and composition (Viitala et al, 2006), feed consumption, and feed conversion efficiency (Banos et al, 2008); and the bGH releasing hormone associated with carcass traits (Cheong et al, 2006). From an interactive network, some of these candidate genes, although not directly related to a determined trait, can have an indirect physiological relationship leading to significant enhancement of a correlated response in another trait (Paredes-Sánchez et al, 2015).…”
ABSTRACT. Polymorphisms in candidate genes can produce significant and favorable changes in the phenotype, and therefore are useful for the identification of the best combination of favorable variants for marker-assisted selection. In the present study, an assessment to evaluate the effect of 11 single nucleotide polymorphisms (SNPs) in candidate genes on live weight traits of registered Brahman cattle was performed. Data from purebred bulls were used in this assessment. The dataset included birth (BW), weaning (WW), and yearling (YW) weights. A panel of 11 SNP markers, selected by their formerly reported or apparent direct and indirect association with live weight traits, was included in an assessment previously confirming their minimum allele frequency (<0.05). Live weights were adjusted BW (aBW), WW (aWW), and YW (aYW) using a generalized linear model, which included the fixed effects of herd and season of birth and the random effect of the sire and year of birth. An SNP in a growth hormone gene (GH4.1) was significantly related to aWW (P = 0.035) with an estimate substitution effect of 3.97 kg (P = 0.0210). In addition, a leptin SNP (LEPg.978) was significantly associated with aYW (P = 0.003) with an estimate substitution effect of 9.57 kg (P = 0.0007). The results suggest that markers GH4.1 and LEPg.978 can be considered as candidate loci for assisted genetic improvement programs in Mexican Brahman cattle.
“…Some of them include the bovine growth hormone (bGH), associated with carcass fat content and muscle yield, milk yield, and testicular development (Yao et al, 1996;Unanian et al, 2002); the receptor of bGH, associated with a large number of productive traits such as milk yield and composition (Viitala et al, 2006), feed consumption, and feed conversion efficiency (Banos et al, 2008); and the bGH releasing hormone associated with carcass traits (Cheong et al, 2006). From an interactive network, some of these candidate genes, although not directly related to a determined trait, can have an indirect physiological relationship leading to significant enhancement of a correlated response in another trait (Paredes-Sánchez et al, 2015).…”
ABSTRACT. Polymorphisms in candidate genes can produce significant and favorable changes in the phenotype, and therefore are useful for the identification of the best combination of favorable variants for marker-assisted selection. In the present study, an assessment to evaluate the effect of 11 single nucleotide polymorphisms (SNPs) in candidate genes on live weight traits of registered Brahman cattle was performed. Data from purebred bulls were used in this assessment. The dataset included birth (BW), weaning (WW), and yearling (YW) weights. A panel of 11 SNP markers, selected by their formerly reported or apparent direct and indirect association with live weight traits, was included in an assessment previously confirming their minimum allele frequency (<0.05). Live weights were adjusted BW (aBW), WW (aWW), and YW (aYW) using a generalized linear model, which included the fixed effects of herd and season of birth and the random effect of the sire and year of birth. An SNP in a growth hormone gene (GH4.1) was significantly related to aWW (P = 0.035) with an estimate substitution effect of 3.97 kg (P = 0.0210). In addition, a leptin SNP (LEPg.978) was significantly associated with aYW (P = 0.003) with an estimate substitution effect of 9.57 kg (P = 0.0007). The results suggest that markers GH4.1 and LEPg.978 can be considered as candidate loci for assisted genetic improvement programs in Mexican Brahman cattle.
“…In animal species with long generation intervals, including cattle, genetic research aimed at the improvement of yield traits using conventional selection methods can be challenging, costly, and time-consuming. However, the marker-assisted selection method, based on the use of conventional selection methods in combination with genetic markers known or considered to be associated with certain yield traits, overcomes these disadvantages (2).…”
“…The growth hormone is involved in multiple physiological processes, including the regulation of growth, development of the mammary glands, onset of lactation, glucogenesis, activation of lypolysis, and regulation of muscle development 6 . In view of the abovementioned effects of the growth hormone, both GH concentration and the allelic variations of the gene coding this hormone have drawn the attention of researchers.…”
Section: Introductionmentioning
confidence: 99%
“…In view of the abovementioned effects of the growth hormone, both GH concentration and the allelic variations of the gene coding this hormone have drawn the attention of researchers. It has been reported that, in cattle, the bGH gene is correlated with certain yield traits, in particular with milk yield and quality, growth 6 , carcass composition and quality 7 . In this context, it is considered that it could be of use as a candidate gene in animal improvement programmes targeted at increasing milk and meat yields 8 .…”
Section: Introductionmentioning
confidence: 99%
“…In this context, it is considered that it could be of use as a candidate gene in animal improvement programmes targeted at increasing milk and meat yields 8 . Previous molecular genetic studies have demonstrated that yield traits such as milk yield and body weight gain are correlated with certain polymorphisms of the bGH gene 6 .…”
SummaryThe purpose of this study was to examine the kappa-casein (κ-CN), growth hormone (bGH) and prolactin hormone (PRL) gene polymorphisms in the Holstein (n=150), Simmental (n=50) and Brown Swiss (n=50) cattle breeds in Turkey. In order to determine the κ-CNHindIII, PRL-RsaI and bGH-AluI polymorphisms, polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) were performed. A 443 bp fragment of κ-CN, a 223 bp fragment of bGH and a 156 bp fragment of PRL were amplified. In this study, two types of alleles, A and B for κ-CN, V and L for bGH, and A and B for PRL, were observed. The cattle breeds in which the highest frequencies of the alleles were estimated, were the HL breed (0.82) for κ-CN-A, the BS breed (0.55) for κ-CN-B, the HL breed (0.85) for bGH-L, the S breed (0.34) for bGH-V, the HL breed (0.87) for PRL-A, and the BS breed (0.24) for PRL-B. According to the results of the chi-square test, a significant deviation from the Hardy-Weinberg equilibrium was determined only for the bGH locus in the investigated breeds. The present study is the first report that examines three loci (κ-CN, bGH and PRL) in three cattle breeds of European origin (Holstein, Simmental and Brown Swiss) raised in Turkey.
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