Investigation of the promoter polymorphisms of the growth hormone (GH1), growth hormone receptor (GHR), insulin-like growth factor (IGF-I), and prolactin (PRL) genes and the correlation between gene expression and milk yields in Holstein cattle raised in Central Anatolia

Arslan, Korhan; Taheri, Serpil; Şener, Elif Funda; Akyüz, Bilal; Akçay, Aytaç; Özkul, Yusuf; Işcan, Kaan M.

doi:10.3906/vet-1510-66

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…However, the effect of genes that are effective regarding traits with economic importance is evaluated by haplotype analysis, and the expected progress can be achieved through molecular genetic breeding. Despite this, some authors (Aggrey et al, 1999;Banos et al, 2008;Li-Juan et al, 2009;Kiyici et al, 2019) observed that GHR/AluI polymorphisms had a significant effect on milk yield traits in Holstein cows. The results were also in the study conducted by El-Nahas et al (2018), who stated that there was a significant relationship between GHR/AluI and PC.…”

Section: Discussionmentioning

confidence: 98%

Determination of the association of GHR/AluI gene polymorphisms with milk yield traits in Holstein and Jersey cattle raised in Turkey

et al. 2021

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Abstract. This research was carried out to determine the effect of a specific single nucleotide polymorphism (SNP) region in exon 10 of the growth hormone receptor (GHR) gene on milk production traits in Jersey and Holstein cows raised in Turkey. Milk samples were recorded as a test day milk yield (TDMY) and an adjusted based 305 d milk yield (305-DMY). Also, milk component traits were detected. Based on the scope of this study, a total of 748 dairy cows, including 305 Holsteins raised in the Marmara Region and 163 Holstein and 280 Jersey raised in the Black Sea Region, were genotyped for the GHR gene using the RFLP-PCR technique. Jersey cows carrying the GG genotype (5.24 %) were associated with higher fat content (P<0.05). Jersey cows with GG and AG also had a higher protein content (3.44 % and 3.38 %, respectively) (P<0.05). Similarly, the protein content was the highest in Holstein cows with the GG genotype (3.46 %) (P<0.01), whereas Holstein cows having AA genotypes displayed higher TDMY (24.64 kg/d) (P<0.05) and 305-DMY (8472.4 kg) (P<0.01). The estimated increase in milk protein and fat contents due to the G allele was 0.07 % and 0.22 % in the Jersey breed, respectively. On the other hand, allele A was highly related to an increase in protein yield and 305-DMY of 0.04 and about 675 kg in the Holstein breed, respectively. The GHR gene should be considered as a potential candidate gene in marker-assisted selection programs to improve the performance of milk and related traits in Turkey dairy cattle populations.

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Section: Discussionmentioning

confidence: 98%

Determination of the association of GHR/AluI gene polymorphisms with milk yield traits in Holstein and Jersey cattle raised in Turkey

et al. 2021

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“…The IGFs family consists of two polypeptide growth factors (IGF-I and IGF-II), two types of receptors (IGF-1R and IGF-2R), and seven binding proteins (IGFBP1-7). The IGFs can promote not only cell growth and development, but also cell differentiation and proliferation (Fan et al, 2005;Arslan et al, 2016). The IGFs are also involved in the metabolism of fat, carbohydrate, and protein (Clemmons D R, 2016).…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms of AluI and Hin1I loci of the IGF-1R gene and their genetic effects on growth traits in Bian chickens

Peng¹,

Wang

Jin³

et al. 2017

Genet. Mol. Res.

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ABSTRACT. Growth traits are important economic traits in broiler chicken production. AluI and Hin1I loci are two restriction sites, which are respectively located in exons 2 and 3 of the IGF-1R gene. These two loci are significantly related to the growth traits in Jinghai Yellow chickens. In this study, a correlation analysis was performed between these two loci and the growth traits of Bian chickens. The results showed a G376A mutation at the AluI site and a C919A mutation at the Hin1I site, which respectively resulted in three genotypes AA, AB, and BB in exon 2 and three genotypes CC, CD, and DD in exon 3. Correlation analysis showed that the female Bian chickens with the AA genotype of the AluI locus had higher body weights than those with the 2 P.F. Wu et al. Genetics and Molecular Research 16 (2): gmr16029619AB genotype (P < 0.05) at 8, 14, 16, and 18 weeks; individuals with CD genotype of Hin1I locus had higher body weights at 6, 8, 10, 12, and 14 weeks compared to the CC genotype (P < 0.05 or P < 0.01). Combined genotypes analysis showed that at the age of 8, 14, 16, and 18 weeks, the body weight of AACC genotype combination was higher than that of the ABCC genotype combination (P < 0.05); at the age of 6, 8, 12, 14, 16, and 18 weeks, the AACD genotype combination had higher (P < 0.05 or P < 0.01) body weight than that of the ABCC genotype.

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Associations Between BLG, CSN3, DGAT1, GH, PIT1, and PRL Gene Polymorphisms and Milk Production Traits in Holstein Dairy Cows: A Meta-Analysis

Ozdemir,

Motmain,

Ekinci

et al. 2024

Biochem Genet

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Investigation of the promoter polymorphisms of the growth hormone (GH1), growth hormone receptor (GHR), insulin-like growth factor (IGF-I), and prolactin (PRL) genes and the correlation between gene expression and milk yields in Holstein cattle raised in Central Anatolia

Cited by 3 publications

References 15 publications

Determination of the association of <i>GHR</i>/<i>AluI</i> gene polymorphisms with milk yield traits in Holstein and Jersey cattle raised in Turkey

Determination of the association of <i>GHR</i>/<i>AluI</i> gene polymorphisms with milk yield traits in Holstein and Jersey cattle raised in Turkey

Polymorphisms of AluI and Hin1I loci of the IGF-1R gene and their genetic effects on growth traits in Bian chickens

Associations Between BLG, CSN3, DGAT1, GH, PIT1, and PRL Gene Polymorphisms and Milk Production Traits in Holstein Dairy Cows: A Meta-Analysis

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Investigation of the promoter polymorphisms of the growth hormone (GH1), growth hormone receptor (GHR), insulin-like growth factor (IGF-I), and prolactin (PRL) genes and the correlation between gene expression and milk yields in Holstein cattle raised in Central Anatolia

Cited by 3 publications

References 15 publications

Determination of the association of &lt;i&gt;GHR&lt;/i&gt;/&lt;i&gt;AluI&lt;/i&gt; gene polymorphisms with milk yield traits in Holstein and Jersey cattle raised in Turkey

Determination of the association of &lt;i&gt;GHR&lt;/i&gt;/&lt;i&gt;AluI&lt;/i&gt; gene polymorphisms with milk yield traits in Holstein and Jersey cattle raised in Turkey

Polymorphisms of AluI and Hin1I loci of the IGF-1R gene and their genetic effects on growth traits in Bian chickens

Associations Between BLG, CSN3, DGAT1, GH, PIT1, and PRL Gene Polymorphisms and Milk Production Traits in Holstein Dairy Cows: A Meta-Analysis

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Determination of the association of <i>GHR</i>/<i>AluI</i> gene polymorphisms with milk yield traits in Holstein and Jersey cattle raised in Turkey

Determination of the association of <i>GHR</i>/<i>AluI</i> gene polymorphisms with milk yield traits in Holstein and Jersey cattle raised in Turkey