Association of polymorphisms in growth hormone and leptin candidate genes with live weight traits of Brahman cattle

Hernandez, Nelida A Gonzalez; Martínez-González, Juan Carlos; Parra‐Bracamonte, Gaspar Manuel; Sifuentes‐Rincón, Ana María; López‐Villalobos, N.; Morris, S. T.; Briones-Encinia, Florencio; Ortega-Rivas, Eligio; Contreras, Víctor Inocencio Pacheco; Meza-García, And L A

doi:10.4238/gmr.15038449

Cited by 10 publications

(8 citation statements)

References 37 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Certain genotypic tendencies are better than others also not seen, although IGFBP-3 is one of the genes responsible for growth, it has a unique mechanism of work that is not yet fully known (Allard and Duan, 2018). IGFBP-3 has indirectly effect on cattle growth, unlike, for example, the Growth Hormone gene, which directly influences the cattle growth (Hernández et al, 2016).…”

Section: Resultsmentioning

confidence: 99%

Association of IGFBP-3 gene polymorphism g. 3.930 G>A with birth size and birth weight in crossbred beef cattle

Hartatik

Priyadi

Panjono

et al. 2019

J. Indonesian Trop. Anim. Agric.

View full text Add to dashboard Cite

Crossing between cattle breeds is the one way to improve the genetic quality of cattle. Controlling crosses using genetic markers will speed up the process. The IGFBP-3 gene is a potential marker of selection due to its role in regulating growth and metabolism in cattle. The aim of this study was to determine the effect of genotype on birth size and birth weight using IBFBP-3 gene marker. A total of 32 cattle consisted of 10 Brahman Cross cattle, 14 cattle results of Brahman Cross cow crosses with Belgian Blue bull, and 8 cattle results of Brahman Cross cow crosses with Wagyu bull. Sequences of 563 bp, including the part intron 2, exon 3, and the part intron 3. Genotyping was done by sequencing method and PCR-RFLP method with the restriction enzyme PvuII. An SNP was identified at location g 3,930 (G>A). Two genotypes were observed, namely GA and GG. The genotype did not affect the performance of birth (body weight, body length, height at withers, heart girth) of the research sample. Birth traits are influenced by the cattle breed, it can be seen that Brahman Cross cattle have a body length that is bigger than the other crossbred.

show abstract

Section: Resultsmentioning

confidence: 99%

Association of IGFBP-3 gene polymorphism g. 3.930 G>A with birth size and birth weight in crossbred beef cattle

Hartatik

Priyadi

Panjono

et al. 2019

J. Indonesian Trop. Anim. Agric.

View full text Add to dashboard Cite

show abstract

“…One of the genes that affect animal weight is the Leptin / LEP gene (Hernandez et al, 2016). Leptin is a hormone that is produced in white adipose tissue and secreted into the bloodstream as a 16 KD protein.…”

Section: Introductionmentioning

confidence: 99%

Short Communication: Identification of Leptin gene in crossbred beef cattle

Anugratama

Hartatik

2019

Biodiversitas

View full text Add to dashboard Cite

Abstract. Anugratama LE, Hartatik T. 2020. Short Communication: Identification of Leptin gene in crossbred beef cattle. Biodiversitas 21: 226-230. Leptin is a gene that affects animal weight. Leptin gene is known to control body weight, feed intake, energy expenditure, immune function, and reproduction. This study aims to identify the diversity of the Leptin gene in crossbred beef cattle, Sumba Ongole cattle, Brahman cross cattle, Bali cattle, buffalo, sheep, and goat by comparing with four GenBank data of cattle. Crossbred beef cattle obtained from Klaten, Central Java, Indonesia. Leptin nucleotide sequences were analyzed using BioEdit to identify Single Nucleotide Polymorphism (SNP). To create amino acid change in Leptin gene, the coding sequence of exon 2 was established using BioEdit ver. 7.0.5. Phylogenetic tree and genetic distance have been analyzed based on the Leptin gene using MEGA 10.1.1 program. The result shows that eight variations of SNP were found in exon 2. The phylogenetic tree represents that crossbreed beef cattle, Sumba Ongole cattle, Brahman cross cattle, Bali cattle, Bos taurus, Bos indicus, Bos frontalis, Bos grunniens, Bubalus bubalis are in the same cluster with various genetic distance. The results of this study are expected to provide genetic information that will be used for further research on the relationship between Leptin gene polymorphisms to animal weight.

show abstract

“…One of these genes, which is potentially polymorphic with a lot of selection benefit is the growth hormone gene [3]. Several studies have indicated the association between polymorphism of the bovine growth hormone (GH) gene and production traits although with divergent results in some cases [4][5][6]. Growth hormone is a polypeptide hormone secreted by somatroph cells from the anterior pituitary glands [7].…”

Section: Introductionmentioning

confidence: 99%

Identification of Bovine Growth Hormone (BGH) Gene Polymorphism Using PCR-RFLP Method in Buffalo Bulls

Shah

Salisi

Wahid

et al. 2019

ARRB

View full text Add to dashboard Cite

Growth Hormone (GH) is a single polypeptide chain synthesised and secreted from anterior pituitary gland by somatroph cells. The product of GH gene hastens metabolism and promotes the growth of many organs and tissues especially bone, muscle and visceral organs. It also regulates growth, mammary gland development and lactation. Polymorphism in this gene is associated with increase in growth and development of many tissues in the body. Aim: The objective of this study was to investigate the polymorphism of bovine growth hormone (bGH) gene in buffalo bulls (Bubalus bubalis) using the PCR-RFLP (polymerase chain reaction–restriction fragment length polymorphism) technique. Design: Genomic DNA was extracted from a total of 10 bulls, consisting of Murrah – Swamp crossbred and pure Swamp buffalo bulls. A The 446 segment of the bGH gene was amplified. The DNA amplicons were detected in 2% agarose gel following 45 minutes of electrophoresis. They were thereafter digesting with AluI endonuclease restriction enzyme, and the digested DNA were detected in 2% agarose gel following electrophoresis for about 45minutes in all samples Results: Similar bands of approximately 300 and 146-bp each, with no variation, were detected in 2% agarose gel following electrophoresis in all the animals tested. Conclusion: Based on the Alu1 digestion result, all samples produced the same allele of the gene, with no polymorphism detected.

show abstract

Association of polymorphisms in growth hormone and leptin candidate genes with live weight traits of Brahman cattle

Cited by 10 publications

References 37 publications

Association of IGFBP-3 gene polymorphism g. 3.930 G>A with birth size and birth weight in crossbred beef cattle

Association of IGFBP-3 gene polymorphism g. 3.930 G>A with birth size and birth weight in crossbred beef cattle

Short Communication: Identification of Leptin gene in crossbred beef cattle

Identification of Bovine Growth Hormone (BGH) Gene Polymorphism Using PCR-RFLP Method in Buffalo Bulls

Contact Info

Product

Resources

About