Polyphenol based hybrid nano-aggregates modified collagen fibers of biological valve leaflets to achieve enhanced mechanical, anticoagulation and anti-calcification properties

Abstract

Glutaraldehyde (Glut)-crosslinked porcine pericardium and bovine pericardium are mainly consisted of collagen and widely used for the preparation of heterogenous bioprosthetic heart valves (BHV), which play an important role in the replacement therapy of severe valvular heart disease, while their durability is limited by degeneration due to calcification, thrombus, endothelialization difficulty and prosthetic valve endocarditis. Herein, we develop a novel BHV, namely, TPly-BP, based on natural tannic acid and polylysine to improve the durability of Glut crosslinked bovine pericardium (Glut-BP). Impressively, tannic acid and polylysine could form nanoaggregates via multiple hydrogen bonds and covalent bonds, and the introduction of nanoaggregates not only improved the mechanical properties and collagen stability but also endowed TPly-BP with good biocompatibility and hemocompatibility. Compared to Glut-BP, TPly-BP showed significantly reduced cytotoxicity, improved endothelial cell adhesion, a low hemolysis ratio and obviously reduced platelet adhesion. Importantly, TPly-BP exhibited great antibacterial and in vivo anti-calcification ability, which was expected to improve the in vivo durability of BHVs. These results suggested that TPly-BP would be a potential candidate for BHV. Graphical abstract

A robust mixed-charge zwitterionic polyurethane coating integrated with antibacterial and anticoagulant functions for interventional blood-contacting devices

“…The hemolysis ratio is an essential factor to consider for the clinical application of blood-contacting devices. 43 To determine the hemolytic effect of the CQPU and CMPU coatings, all samples were exposed to diluted erythrocytes for 1 h. As displayed in Fig. 8b, the hemolysis ratio of the CQPU coating exhibited a high hemolysis ratio of 23.1%.…”

Correction: Ethics approval and consent to participate

“…Following publication of the original article [3], it was found in the 'Ethics approval and consent to participate' section is incorrect, the correct 'Ethics approval and consent to participate' section is provided below:…”

Metallic‐Polyphenolic Nanoparticles Reinforced Cationic Guar Gum Hydrogel for Effectively Treating Burn Wound

“…Metallic‐polyphenolic nanoparticles provide an effective approach [ 19 ] to prepare multifunctional hydrogels, which is a simple green process that can combine metal ions [ 20 ] and functional plant polyphenols [ 21,22 ] by adjusting the preparation conditions of ions and polyphenols. [ 23 ] Researchers have demonstrated that both metal ions and plant polyphenols have strong reversible interactions with CG molecules.…”

“…[11] The introduction of crosslinkers is a simple and effective method for advanced CG modification, and some researchers use this method to improve various properties of CG, such as moisturizing, antibacterial, anti-inflammatory, etc., but unsatisfactory. [17,18] Metallic-polyphenolic nanoparticles provide an effective approach [19] to prepare multifunctional hydrogels, which is a simple green process that can combine metal ions [20] and functional plant polyphenols [21,22] by adjusting the preparation conditions of ions and polyphenols. [23] Researchers have demonstrated that both metal ions and plant polyphenols have strong reversible interactions with CG molecules.…”