A robust mixed-charge zwitterionic polyurethane coating integrated with antibacterial and anticoagulant functions for interventional blood-contacting devices

Peng, Jinyu; Li, Kaijun; Du, Yangrui; Feng, Yang; Wu, Lijun; Liu, Gongyan

doi:10.1039/d3tb01443f

Cited by 5 publications

(2 citation statements)

References 50 publications

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“…This finding can be mainly attributed to the cationic quaternary ammonium salts on the surfaces of IPUDM-SB and HUDM-SB coatings, which actively engage negatively charged bacteria through electrostatic interactions, resulting in cell-membrane rupture, cytoplasm leakage, and bacterial death. The ions thus exert antibacterial effects [40,41].…”

Section: Antibacterial Performance Of the Coatingsmentioning

confidence: 99%

Sustainable Coating Based on Zwitterionic Functionalized Polyurushiol with Antifouling and Antibacterial Properties

Xu,

Xie,

Sun

et al. 2023

Molecules

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Zwitterionic polymer coatings facilitate the formation of hydration layers via electrostatic interactions on their surfaces and have demonstrated efficacy in preventing biofouling. They have emerged as a promising class of marine antifouling materials. However, designing multifunctional, environmentally friendly, and natural products-derived zwitterionic polymer coatings that simultaneously resist biofouling, inhibit protein adhesion, exhibit strong antibacterial properties, and reduce algal adhesion is a significant challenge. This study employed two diisocyanates as crosslinkers and natural urushiol and ethanolamine as raw materials. The coupling reaction of diisocyanates with hydroxyl groups was employed to synthesize urushiol-based precursors. Subsequently, sulfobetaine moieties were introduced into the urushiol-based precursors, developing two environmentally friendly and high-performance zwitterionic-functionalized polyurushiol antifouling coatings, denoted as HUDM-SB and IPUDM-SB. The sulfobetaine-functionalized polyurushiol coating exhibited significantly enhanced hydrophilicity, with the static water contact angle reduced to less than 60°, and demonstrated excellent resistance to protein adhesion. IPUDM-SB exhibited antibacterial efficacy up to 99.9% against common Gram-negative bacteria (E. coli and V. alginolyticus) and Gram-positive bacteria (S. aureus and Bacillus. sp.). HUDM-SB achieved antibacterial efficacy exceeding 95.0% against four bacterial species. Furthermore, the sulfobetaine moieties on the surfaces of the IPUDM-SB and HUDM-SB coatings effectively inhibited the growth and reproduction of algal cells by preventing microalgae adhesion. This zwitterionic-functionalized polyurushiol coating does not contain antifouling agents, making it a green, environmentally friendly, and high-performance biomaterial-based solution for marine antifouling.

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Section: Antibacterial Performance Of the Coatingsmentioning

confidence: 99%

Sustainable Coating Based on Zwitterionic Functionalized Polyurushiol with Antifouling and Antibacterial Properties

Xu,

Xie,

Sun

et al. 2023

Molecules

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“…[24][25][26] One way to find a solution to these problems is exploring different polymers and utilizing their antibacterial potentials. [27][28][29][30][31] The polymers which were studied extensively for evaluating their antimicrobial properties include polyurethane, pyridinium polymers, alkoxysilanes, polyionenes and polyethyleneimine. [32][33][34][35] These compounds' low propensity to develop resistance and their quick bactericidal impact are just two of their many benefits.…”

Section: Introductionmentioning

confidence: 99%

Structure–activity relationship of drug conjugated polymeric materials against uropathogenic bacteria colonization under in vitro and in vivo settings

Sarkar,

Moitra,

Bhattacharya

2024

J. Mater. Chem. B

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A simple and efficient strategy for preparing anticoagulant coatings on biomedical polyurethane surfaces through a fluorinated urethane prepolymer

Zhang,

Tang,

Cai

et al. 2024

Progress in Organic Coatings

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A robust mixed-charge zwitterionic polyurethane coating integrated with antibacterial and anticoagulant functions for interventional blood-contacting devices

Abstract: Antifouling coatings based on zwitterionic polymers have been widely applied for surface modification of interventional blood-contacting devices to combat thrombosis and infection. However, the weak adhesion stability of zwitterionic coating...

Cited by 5 publications

References 50 publications

Sustainable Coating Based on Zwitterionic Functionalized Polyurushiol with Antifouling and Antibacterial Properties

Sustainable Coating Based on Zwitterionic Functionalized Polyurushiol with Antifouling and Antibacterial Properties

Structure–activity relationship of drug conjugated polymeric materials against uropathogenic bacteria colonization under in vitro and in vivo settings

A simple and efficient strategy for preparing anticoagulant coatings on biomedical polyurethane surfaces through a fluorinated urethane prepolymer

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