Polymorphism of the BoLA System

Caldwell, J. D.

doi:10.1111/j.1399-0039.1979.tb00803.x

Cited by 20 publications

(6 citation statements)

References 10 publications

(12 reference statements)

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“…For example, specificity CA1 was present in 20 out of 31 Murray Grey animals examined; however, this specificity was absent in 199 cross-bred cattle (314 Brahman X 1/4 Shorthorn). Amorena & Stone (1978), Caldwell (1979) and Oliver et al (1981) have also reported breed differences in antigen frequency. At present, we are uncertain if the differences are due to breed effects or to founder effects, sire effects or the stochastic effects of small sample size, but we are currently looking into this.…”

Section: Discussionmentioning

confidence: 95%

“…Another method which has been used to assign antigens to loci is population analysis (Andresen et al 1963, Andresen & Baker 1964. Although this method has been used by Caldwell (1979) and by Adams & Brandon (1981), it may not be appropriate for studies with closely-linked loci in cattle because two of the requirements for this test are the absence of linkage disequilibrium and the existence of Hardy-Weinberg equilibrium. Although no information exists about linkage disequilibrium of the genes controlling bovine lymphocyte antigens, information obtained from other species suggests that alleles of closelylinked loci will show linkage disequilibrium (Svejgaard et al 1971, Andresen 1980.…”

Section: Discussionmentioning

confidence: 99%

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Two closely linked loci and one apparently independent locus code for bovine lymphocyte antigens

1982

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Twenty different antigens have been detected on bovine lymphocytes. Family studies suggested that 19 of the antigens were under the control of two closely‐linked loci. The remaining antigen was apparently coded for by an independent locus. The distribution of the antigens in the population also suggested that three loci control the expression of lymphocyte antigens. A co‐capping study on two antigens which were inherited together on one haplotype showed that these antigens were expressed on different molecules on the lymphocyte membrane, providing further evidence for the existence of two linked loci.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Two closely linked loci and one apparently independent locus code for bovine lymphocyte antigens

1982

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“…Biochemical characteristics of bovine class I and I1 molecules are in agreement with those found for the corresponding molecules of man and mouse (Hoang-Xuan et al 1982a,b;Chardon et al 1983). The BOLA-A locus has been defined serologically (Amorena 81 Stone 1978;Spooner et al 1978;Caldwell 1979) and 17 international workshop specificities are now recognized (Anon. 1982).…”

mentioning

confidence: 99%

Genomic hybridization of bovine class II major histocompatibility genes: 1. Extensive polymorphism of DQα and DQβ genes

et al. 1986

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Class I1 genes of the bovine major histocompatibility complex (MHC) were investigated by Southern blot analysis using human cDNA probes for D Q a , DQP, D R a and DRP. The presence of a DQ-like and a DR-like subregion in cattle was clearly indicated. Highly polymorphic restriction fragment patterns were obtained when genomic DNA, digested with any one of the BamH1, EcoRI or PvuII restriction enzymes, was hybridized with the D Q a and the DQP probe. The polymorphisms were interpreted genetically by analysing five paternal half-sib families of the Swedish Red and White breed. The material comprised, besides the bulls, 28 offspring and their dams. The analysis resolved 9 and 12 allelic variants of D Q a and D O @ respectively. Thus, this investigation establishes a method for routine typing of MHC class I1 gene polymorphism in cattle. The results were entirely consistent with close linkage of DQa and DQP since no recombinant was found and since alleles at these loci occurred in complete linkage disequilibrium in the material investigated. Close linkage between D Q and the blood group locus M , which has previously been found to be closely linked to the serologically defined B O L A -A locus, was also indicated. In this study DNA was isolated from frozen semen samples of dead bulls, which shows that this type of analysis will be useful in genetic investigations in cattle breeds, where artificial insemination is practised.K~ywordst cattle, genetic polymorphism, RFLP, major histocompatibility complex, Southern blot analysis. lntroductionThe major histocompatibility complex (MHC) of vertebrates includes class I and class I1 genes which encode cell-surface proteins with a central function in the immune system (Klein 1975;Zinkernagel & Doherty 1979;Nagy et al.

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“…The existence of a single polymorphic locus controlling the SD antigens of cattle has been reported also by Caldwell (1979). In contrast, Spooner et al (1978) claimed that several loci were involved but they did not specify the exact number, nor the alleles belonging to each.…”

Section: Discussionmentioning

confidence: 99%

Bovine Lymphocyte Antigens (BoLA): A Serologic, Genetic and Histocompatibility Analysis

Amorena

Stone

1980

Tissue Antigens

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Eleven lymphocyte antigens have been defined in cattle using 81 lymphocytotoxic sera. These sera (typing reagents) were selected from over 1,000 normal sera, 35 alloimmune sera, and 111 samples of colostrum whey. Absorptions revealed that nine of the 11 antigens detected by these reagents are serologically independent. Segregation of the genes controlling these antigens was observed among 470 calves from matings of 56 heterozygous sires and 360 dams, indicating that each of the 11 antigens is controlled by one of 11 alleles at a single autosomal co-dominant locus BOLA-A (Bovine Lymphocyte Antigen, locus A). To determine the relation between BoLA antigens and histocompatibility, skin allografts were exchanged among four unrelated adult cows. Incompatibilities for the SD antigens, but not MLR or blood group antigens, were predictive of early rejection of allografts. Furthermore, graft recipients produced antibodies against the SD antigens of incompatible donors. These results indicate that the BOLA-A locus is part of the major histocompatibility complex (MHC) of cattle.

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Polymorphism of the BoLA System

Cited by 20 publications

References 10 publications

Two closely linked loci and one apparently independent locus code for bovine lymphocyte antigens

Two closely linked loci and one apparently independent locus code for bovine lymphocyte antigens

Genomic hybridization of bovine class II major histocompatibility genes: 1. Extensive polymorphism of DQα and DQβ genes

Bovine Lymphocyte Antigens (BoLA): A Serologic, Genetic and Histocompatibility Analysis

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