Two closely linked loci and one apparently independent locus code for bovine lymphocyte antigens

Abstract

Twenty different antigens have been detected on bovine lymphocytes. Family studies suggested that 19 of the antigens were under the control of two closely‐linked loci. The remaining antigen was apparently coded for by an independent locus. The distribution of the antigens in the population also suggested that three loci control the expression of lymphocyte antigens. A co‐capping study on two antigens which were inherited together on one haplotype showed that these antigens were expressed on different molecules on the lymphocyte membrane, providing further evidence for the existence of two linked loci.

Serological and genetic identification of a bovine B lymphocyte alloantigen system

“…Multilocus control of class I antigens is well established in several species (Gotze, 1977) and has now been suggested for cattle Stear et al, 1982). As well, the multilocus nature of the mouse I region is well established (David, 1976).…”

“…So far, only a limited number of serologically defined antigens (class I) have been described accurately. Evidence suggests that most of the presently defined specificities belong to the same genetic system which may be single-locus or multi-locus in nature (Amorena & Stone, 1978;Caldwell & Cumberland, 1978;Spooner et al, 1978;Stear, Newman & Nicholas, 1982). The system is highly polymorphic and large variations in the distribution of antigenic specificities are found in different breeds (Caldwell et al, 1979;Oliver et al, 1981).…”

Mixed lymphocyte reactivity in cattle

“…BoLA Class I antigen types were determined using the antisera and methods described previously (Stear et al 1981).…”

Detection of a new non‐MHC alloantigenic system (SLD) in pigs

“…The most intensive investigations of leucocyte antigens coded for by genes located on other chromosomes than the MHC loci have been performed in mice (reviewed by McKenzie & Potter, 1979). But also in humans (Singal, Sengar & Terasaki, 1970;Legrand & Dausset, 1975), in the horse (Lazary et al, 1982), in cattle (Stear, Newman & Nicholas, 1982), in sheep (Millot, 1979) and in dogs (Krumbacher & Schnauppauf, 1976), non-MHC linked alloantigenic systems have been found.…”