Polymorphism of genes encoding proteins of DNA repair
vs. occupational and environmental exposure to lead, arsenic and pesticides

Bukowski, Karol; Woźniak, Katarzyna

doi:10.13075/mp.5893.00595

Cited by 8 publications

(7 citation statements)

References 30 publications

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“…Polymorphism may also apply to genes encoding DNA repair enzymes, which is related to the speed and efficiency of DNA repair, which may protect or expose a person to the effects of specific xenobiotics [ 91 ]. One of the studied polymorphisms is the nucleotide excision repair (NER) polymorphism, which is an important defense mechanism for an organism against mutagens and carcinogens, such as B[ a ]P. Genetic polymorphisms in ERCC2/XPD , a crucial component in NER, are believed to be linked with cancer risk development.…”

Section: Metabolism Of B[ a ]Pmentioning

confidence: 99%

Benzo[a]pyrene—Environmental Occurrence, Human Exposure, and Mechanisms of Toxicity

Bukowska

Mokra

Michałowicz

2022

IJMS

123

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Benzo[a]pyrene (B[a]P) is the main representative of polycyclic aromatic hydrocarbons (PAHs), and has been repeatedly found in the air, surface water, soil, and sediments. It is present in cigarette smoke as well as in food products, especially when smoked and grilled. Human exposure to B[a]P is therefore common. Research shows growing evidence concerning toxic effects induced by this substance. This xenobiotic is metabolized by cytochrome P450 (CYP P450) to carcinogenic metabolite: 7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE), which creates DNA adducts, causing mutations and malignant transformations. Moreover, B[a]P is epigenotoxic, neurotoxic, and teratogenic, and exhibits pro-oxidative potential and causes impairment of animals’ fertility. CYP P450 is strongly involved in B[a]P metabolism, and it is simultaneously expressed as a result of the association of B[a]P with aromatic hydrocarbon receptor (AhR), playing an essential role in the cancerogenic potential of various xenobiotics. In turn, polymorphism of CYP P450 genes determines the sensitivity of the organism to B[a]P. It was also observed that B[a]P facilitates the multiplication of viruses, which may be an additional problem with the widespread COVID-19 pandemic. Based on publications mainly from 2017 to 2022, this paper presents the occurrence of B[a]P in various environmental compartments and human surroundings, shows the exposure of humans to this substance, and describes the mechanisms of its toxicity.

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Section: Metabolism Of B[ a ]Pmentioning

confidence: 99%

Benzo[a]pyrene—Environmental Occurrence, Human Exposure, and Mechanisms of Toxicity

Bukowska

Mokra

Michałowicz

2022

IJMS

123

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“…Хоча білок XRCC1 немає каталітич-ної активності, але сприяє відновленню ДНК при взаємодії з ферментами репарації: ДНК-лігазою ІІІ, ДНК-полімеразою-ß [12,13]. XRCC1 у комплексі з ДНК-полімеразою бере участь у відновленні одноланцюгових пошкоджень [14,15].…”

Section: вступunclassified

“…nucleotide excision repair) забезпечують видалення пошкоджених нуклеотидів з наступним від-новленням структури молекули ДНК, через розпізнавання і виправлення зшивок основ [15]. XPD (від англ.…”

Section: вступunclassified

“…Ми вивчали алельні поліморфізми XPD (rs13181 і rs799793), які впливають на ефективність діяльності NER. Конформаційний стан ділянки білка XPD, в якому відбувається заміна, впли-ває на стабільність TFIIH і на хеліказну активність [5,6,15]. Згідно з літературними даними, у носіїв мінорного генотипу XPD•С/С (rs13181) спостерігається знижена здатність до репарації ДНК, а це призводить до неповноцінного відновлення спадкової інформації при дії хімічних мутагенів та ультрафіолетового опромінення [9].…”

Section: вступunclassified

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Genetic Predisposition to Bronchopulmonary Pathology in Workers of Harmful and Hazardous Industries: Analysis of Five Polymorphisms of Dna Gene Repair

Andrushchenko¹,

Гончаров²,

Dosenko³

2018

Fiziol Zh

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“…Для изучения ассоциаций определённых генотипов генов репарации с риском развития БЛП были определены их частоты: XPD (rs13181, rs799793) и ERCC1 (rs11615). Следует отметить, что получен- ные частоты генотипов изучаемых полиморфизмов были близки к популяционным частотам в европейской популяции, что по данным литературы составляет: -по гену XPD (rs 13181) доминантные гомозиготы -XPD*A/A -35,4%, гетерозиготы XPD*A/С -52,4%, минорные гомозиготы XPD*С/С -12,2%; -по гену XPD (rs 799793) доминантные гомозиготы -XPD*Asp/Asp -до 43%; гетерозиготы XPD*Asp/Asn -50-53%, минорные гомозиготы XPD*Asn/Asn -17%; -по гену ERCC1 (rs11615) доминантные гомозиготы -ERCC1*С/С -до 50%; гетерозиготы ERCC1*С/Т -30%, минорные гомозиготы ERCC1*Т/Т -17% [3,4,5,9,10]. При анализе частот генотипов гена XPD (rs799793) в популяции работников АЦЗ носители генотипа XPD*Asn/Asn в группе иследования составили -13,1%, в группе контроля минорные гомозиготы не встречались (χ 2 =6,62, р≤0,01), что свидетельствует о повышенном риске развития БЛП в группе исследования АЦЗ (OR=2,20; 95%CI:1,75-2,77).…”

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Polymorphism of DNA repair genes in bronchopulmonary pathology in workers of harmful and dangerous industries

Andruschenko

Honcharov²,

Dolinchuk

et al. 2018

UJMTA

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Introduction. Polymorphism of DNA repair genes is actively studied in the formation of the individual sensitivity of the genome to damaging mutagenic effects. Objective of the work. To study the distribution of frequencies of alleles and genotypes of DNA repair genes: XPD (rs13181, rs799793) and ERCC1 (rs11615) in workers of asbestos-cement plants and miners to identify risk markers for bronchopulmonary pathology. Material and methods. The study included workers of asbestos-cement plants and miners (n=214). Real-time polymerase chain reaction was used to determine genotypes of XPD (rs13181, rs799793) and ERCC1 (rs11615) genes. Results. The study determined alleles and genotypes associated with the risk of developing bronchopulmonary pathology: - in the population of workers of asbestos-cement plants: XPD*Asn/Asn (rs799793), (p<0.01; χ2=6.62; OR=2,20; 95 %CI: 1,75–2,77); - in the population of miners: XPD*C (rs13181), (p<0.02; χ2=4,99; OR=1,88; 95 %CI: 1,04–3,40); XPD*CC (rs13181), (p<0,003; χ2=8.61; OR=4,29; 95 %CI: 1,41–13,37). The study also detected allele XPD*A (rs13181), which in the population of miners proved to be a marker of resistance to bronchopulmonary pathology (p<0,02; χ2=4.99; OR=0,53; 95 %CI: 0,29–0,96). Conclusions. The study has identified alleles and genotypes associated with the risk of developing bronchopulmonary pathology in the population of workers in harmful and dangerous production facilities of Ukraine. The study has determined the genotype and allele that can be used as biomarkers of resistance to the pathology of the respiratory system. Key words: molecular-genetic markers, XPD and ERCC1, bronchopulmonary pathology.

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Polymorphism of genes encoding proteins of DNA repair vs. occupational and environmental exposure to lead, arsenic and pesticides

Cited by 8 publications

References 30 publications

Benzo[a]pyrene—Environmental Occurrence, Human Exposure, and Mechanisms of Toxicity

Benzo[a]pyrene—Environmental Occurrence, Human Exposure, and Mechanisms of Toxicity

Genetic Predisposition to Bronchopulmonary Pathology in Workers of Harmful and Hazardous Industries: Analysis of Five Polymorphisms of Dna Gene Repair

Polymorphism of DNA repair genes in bronchopulmonary pathology in workers of harmful and dangerous industries

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