Polymeric Biomaterials in Tissue Engineering

Kohane, Daniel S.; Langer, Robert

doi:10.1203/01.pdr.0000305937.26105.e7

Cited by 300 publications

(161 citation statements)

References 65 publications

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“…Multiple polymeric biomaterials have been studied for tissue engineering [81][82][83]; however, only few of them are really used in the current clinical practice. Therefore, we will review the main research works on LST of those currently used for medical applications, especially on those used in bone tissue engineering [84].…”

Section: Laser Surface Texturing Of Biomedical Polymersmentioning

confidence: 99%

Laser Surface Texturing of Polymers for Biomedical Applications

et al. 2018

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Polymers are materials widely used in biomedical science because of their biocompatibility, and good mechanical properties (which, in some cases, are similar to those of human tissues); however, these materials are, in general, chemically and biologically inert. Surface characteristics, such as topography (at the macro-, micro, and nano-scale), surface chemistry, surface energy, charge, or wettability are interrelated properties, and they cooperatively influence the biological performance of materials when used for biomedical applications. They regulate the biological response at the implant/tissue interface (e.g., influencing the cell adhesion, cell orientation, cell motility, etc.). Several surface processing techniques have been explored to modulate these properties for biomedical applications. Despite their potentials, these methods have limitations that prevent their applicability. In this regard, laser-based methods, in particular laser surface texturing (LST), can be an interesting alternative. Different works have showed the potentiality of this technique to control the surface properties of biomedical polymers and enhance their biological performance; however, more research is needed to obtain the desired biological response. This work provides a general overview of the basics and applications of LST for the surface modification of polymers currently used in the clinical practice (e.g., PEEK, UHMWPE, PP, etc.). The modification of roughness, wettability, and their impact on the biological response is addressed to offer new insights on the surface modification of biomedical polymers.

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Section: Laser Surface Texturing Of Biomedical Polymersmentioning

confidence: 99%

Laser Surface Texturing of Polymers for Biomedical Applications

et al. 2018

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“…For example, the incorporation of drugs into scaffolds is an enormous challenge in tissue engineering [29,30]. However, because bacterial cellulose is hydrogel-like, with a high water holding capacity, it may be possible to incorporate drugs and growth factors in the scaffold.…”

Section: Cell Studymentioning

confidence: 99%

Microporous bacterial cellulose as a potential scaffold for bone regeneration

et al. 2010

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a b s t r a c tNanoporous cellulose biosynthesized by bacteria is an attractive biomaterial scaffold for tissue engineering due to its biocompatibility and good mechanical properties. However, for bone applications a microscopic pore structure is needed to facilitate osteoblast ingrowth and formation of a mineralized tissue. Therefore, in this study microporous bacterial cellulose (BC) scaffolds were prepared by incorporating 300-500 lm paraffin wax microspheres into the fermentation process. The paraffin wax microspheres were subsequently removed, and scanning electron microscopy confirmed a microporous surface of the scaffolds while Fourier transform infrared spectroscopy verified the elimination of paraffin and tensile measurements showed a Young's modulus of approximately 1.6 MPa. Microporous BC and nanoporous (control) BC scaffolds were seeded with MC3T3-E1 osteoprogenitor cells, and examined by confocal microscopy and histology for cell distribution and mineral deposition. Cells clustered within the pores of microporous BC, and formed denser mineral deposits than cells grown on control BC surfaces. This work shows that microporous BC is a promising biomaterial for bone tissue engineering applications.

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“…Depending on the network and nature of therapeutic substance, a method is selected which has specific advantages and disadvantages. [170][171][172] The simplest method of drug loading is the diffusion method which includes placement of hydrogel system in the solution containing a therapeutic agent. Depending upon the hydrogel network, size of the drug molecules sample component to total composition analysis, into an analytically useful signal.…”

Section: Drug Loading and Releasementioning

confidence: 99%

Insight into hydrogels

Khan

Ullah

et al. 2016

Designed Monomers and Polymers

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The development and introduction of injectable biomaterials and the identification of methods through which materials may form in situ are currently the topics of interest in materials science, specifically in the field of biomaterials. Over the last few decades, hydrogels which refers to the swellable polymeric matrices have gained wide attention due to their excellent characteristics such as swelling in different media, pH and temperature sensitivity, and sensitivity to other stimuli. Nowadays, injectable hydrogels have widely been studied due to their excellent insitu gelation at body temperature. These injectable insitu gels serve as depot system which ensures the local and systemic drug and gene delivery. These insitu gels also protect the proteins and peptide drugs invivo from environmental effect. The current review is made to report latest extensive literature regarding hydrogels, their classification, synthesis methods, structure of hydrogel network, methods of crosslinking, environment-sensitive hydrogel system, drug loading, and release, hydrogels as biosensors and applications of hydrogels.

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Polymeric Biomaterials in Tissue Engineering

Cited by 300 publications

References 65 publications

Laser Surface Texturing of Polymers for Biomedical Applications

Laser Surface Texturing of Polymers for Biomedical Applications

Microporous bacterial cellulose as a potential scaffold for bone regeneration

Insight into hydrogels

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