Poly (Glycerol Sebacate)-Based Bio-Artificial Multiporous Matrix for Bone Regeneration

Abstract

In recent years, bone repair biomaterials that combine cells and bioactive factors are superior to autologous and allogeneic bone implants. However, neither natural nor synthetic biomaterials can possess all desired qualities such as strength, porosity, and biological activity. In this study, we used poly (glycerol sebacate) (PGS), a synthetic material with great osteogenic potential that has attracted more attention in the field of tissue (such as bone tissue) regeneration owing to its good biocompatibility and high elasticity. It also has the advantage of being regulated by material synthesis to match the bone tissue's strength and can be easily modified to become functional. However, pure PGS lacks functional groups and hydrophilicity. Therefore, we used PGS as the substrate to graft the adhesive ligands RGD and vascular endothelial growth factor mimetic peptide. The bone repair scaffold can be prepared through photo crosslinking, as it not only improves hydrophobicity but also promotes vascularization and accelerates osteogenesis. Simultaneously, we improved the preparation method of hydrogels after freeze-drying and crosslinking to form a sponge-like structure and to easily regenerate blood vessels. In summary, a bone repair scaffold was prepared to meet the structural and biological requirements. It proved to serve as a potential bone-mimicking scaffold by enhancing tissue regenerative processes such as cell infiltration and vascularization and subsequent replacement by the native bone tissue.

A Novel Immunoregulatory PEGylated Poly(glycerol sebacate)/β‐TCP Membrane for Application in Guided Bone Regeneration

“…Liang et al. [ 13 ] showed that PGS loaded with the adhesive ligands RGD and VEGF mimetic peptide could serve as a potential bone‐mimicking scaffold by enhancing cell infiltration, vascularization, and subsequent bone regeneration processes. Zaky et al.…”

“…Zaky et al [12] reported the successful application of PGS bioscaffolds in repairing critical-sized ulna defects in rabbits. Liang et al [13] showed that PGS loaded with the adhesive ligands RGD and VEGF mimetic peptide could serve as a potential bone-mimicking scaffold by enhancing cell infiltration, vascularization, and subsequent bone regeneration processes. Zaky et al [14] confirmed that PGS contributed to bone regeneration by recruiting MSCs and enhancing the osteogenic differentiation of MSCs by transmitting mechanical stimulation to the MSCs.…”

Poly(Glycerol Sebacate) in Biomedical Applications—A Review of the Recent Literature

“…The temperature is raised to room temperature and hold again for several hours, completing the freeze‐drying procedure. [ 22,50,53,148,150 ]…”

“…The temperature is raised to room temperature and hold again for several hours, completing the freeze-drying procedure. [22,50,53,148,150] Frydrych et al [22] used a PGS/PLLA mixture to replicate native fatty tissue. Fatty tissue is a specialized connective soft tissue composed of adipocytes.…”

Silibinin Promotes Bone Regeneration Through HIF-1α/VEGF and Notch Signaling Pathway in Ovariectomized Rats

“…When the bone defect reaches a certain limit, it is di cult to complete the defect healing by its own repair ability. The autologous bone graft has good biocompatibility and bone-inducing ability, demonstrating the gold standard for bone defect healing [5]. However, autologous bone grating is limited by donor site morbidity, which will inevitably lead to extension of surgical time, increase of surgical sites and infection chance and aggravation of patient pain [6,7].…”