Poly(ethoxytriethyleneglycol acrylate) cryogels as novel sustained drug release systems for oral application

A Brief History of Polymeric Cryogels

“…The efficiency of radiation-induced processes is mainly a function of the applied radiation dose but not of the temperature, as demonstrated in the pioneering studies conducted in Japan (see, e.g., [19,[93][94][95][96][97][98][99][100]). Yet another possibility for the preparation of cryogels of the polymerization type is the use of electron beams [101] or photoinitiation [102][103][104]. An essential point in this case is that the penetration capability of both these kinds of radiation is not very high, which limits the thickness of the samples.…”

“…Synthesis and study of cryogelbased drug release matrices [104] Urethane diacrylate + poly(L-lactic acid)…”

Cryogels via UV Irradiation

“…The choice of a powerful source of UV light seems to be the crucial factor for fast monomer conversion and formation of polymer network. The results from experiments carred out with a Dymax 5000-EC UV curing equipment with 400 W metal halide flood lamp emitting full spectrum UV-visible light at an irradiation dose rate of 5.7 J/cm 2 min (input power 93 mW/cm 2 ) showed that 5 min of irradiation is sufficient for preparation of disk-shaped cryogels of good quality [16,21,22]. Moreover, in the case of NIPAAm, ETEGA, and AAm, cryogels of extremely high GF yield (nearly quantitative monomer conversion) were obtained (Table 3).…”

“…Thus, it has an advantage over the conventional system, characterized by a spontaneous release of the active substance immediately after administration (known as the "burst" effect) [36]. The potential of polymer cryogels for encapsulation and sustained release of hydrophilic drugs has been investigated [21,22]. By design, the water-soluble drug verapamil hydrochloride was entrapped in the walls of different cryogels.…”

Biosurfactant Production by Pseudomonas aeruginosa BN10 Cells Entrapped in Cryogels

“…This method allows preparation of various biocompatible, biodegradable, and/or thermosensitive supermacroporous cryogels by irradiation of moderately frozen aqueous systems with UV light (irradiation dose rate of 950 J m -2 s -1 ) for 2 -5 minutes in the presence of a photoinitiator. Such materials have been exploited for immobilization of yeast cells (Velickova et al, 2010), bacteria capable to degrade xenobiotics (Satchanska et al, 2009;Topalova et al, 2011), fi broblast cells (Petrov et al, 2011a), enzymes (Petrov et al, 2011b(Petrov et al, , 2012, and drugs Kostova et al, 2011).…”