Poly(2‐[α‐³H]vinylpyridine 1‐oxide)

Abstract

Poly(2-vinylpyridine 1-oxide), when injected into animals, counteracts the pathogenic effects of inhaled silica dust. To study its distribution in the cells, a specifically labelled polymer has been synthesised by reducing 2-acetylpyridine with tritium, dehydrating, polymerising then oxidizing the polyvinyl product. Some of the tritium (17 yo) enters the aromatic ring by exchange and there is a small loss of tritium by exchange with solvents.A t the stage of reduction, there is preference for C-T bond formation rather then C-H. ZUSAMMENFASSUNG:In Tiere injiziertes Poly-(2-vinylpyridin-l-oxid) verhindert die pathogenen Effekte von inhaliertem Siliciumdioxid-Staub. Um die Verteilung in den Zellen zu studieren, wurde ein spezifisch markiertes Polymeres durch Reduktion von 2-Acetylpyridin mit Tritium, Dehydratisierung, anschlieaender Polymerisation und Oxydation des Polyvinylprodukts hergestellt. Ein Ted des Tritiums (17 %) wird durch Austausch in den aromatischen Ring eingebaut, ein kleiner Teil geht durch Austausch mit den Losungsmitteln verloren. Bei der Reduktionsstufe werden mehr C-T-als C-H-Bindungen gebildet.

Fluorescence, Metal Ion Binding, and Viscosity Properties of Poly[2- and 4-vinylpyridine N-oxide]s in Aqueous Solution

“…P2VPNO and P4VPNO were synthesized as described in the literature. 1,5 Poly(2-and 4-vinylpyridine)s. The monomers 2-and 4-vinylpyridines were purchased from Aldrich and vacuum distilled to remove inhibitor before use. Poly(2-vinylpyridine) (P2VP) and poly(4-vinylpyridine) (P4VP) were prepared by a free-radical polymerization in methanol.…”

“…Poly(vinylpyridine N -oxide)s (Figure ) were synthesized and characterized about 3 decades ago . Poly(2-vinylpyridine N -oxide) (P2VPNO) was used as a chemotherapeutic agent against silicosis and inhibits the fibrogenesis normally caused by quartz dust in the lungs of animals .…”

“…Poly(vinylpyridine N-oxide)s (Figure 1) were synthesized and characterized about 3 decades ago. 1 Poly(2vinylpyridine N-oxide) (P2VPNO) was used as a chemotherapeutic agent against silicosis 2 and inhibits the fibrogenesis normally caused by quartz dust in the lungs of animals. 3 Poly(vinylpyridine N-oxide)s (PVPNO) form complexes with dichromates and were applied as versatile oxidizing agents for organic compounds.…”

Iodine bactericidal action adsorbed in 2‐vinylpyridine copolymer networks

“…Literature has pointed out that poly(vinylpyridine N ‐oxide) would inhibit the pathogenic activity of a microorganism 10. For applications in aqueous systems (e.g., sterilized distilled water), in biomedicine, and reactions using polymer as support, it is of interest to have a suitable accessibility to the polymer matrix (wetting).…”

Factors Involved in the Cytotoxicity of Kaolinite towards Macrophages in Vitro

“…PVPNO was synthesized according to the method of Gregson and Holt(14).To sterile centrifuge tubes containing 10 mg ka-Effect of PVPNO treated kaolinite on lactate dehydrogenase release from macrophages: (Fe3O4) 40 mg/cm3 magnetite; (n.d.) no dust.…”