Factors Involved in the Cytotoxicity of Kaolinite towards Macrophages in Vitro

Davies, Rhian

doi:10.2307/3429759

Cited by 5 publications

(3 citation statements)

References 2 publications

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“…Recent studies indicate that kaolin particles are cytotoxic to mammalian macrophages due to release of lysosomal and cytoplasmic enzymes and inhibition of protein synthesis (Davis, Mortara & Green 1975;Low, Leffingwell & Bulman 1980;Davies 1983). Although no cytopathological changes were observed in kaolin phagocytes in this study, further work is needed to determine whether similar biochemical alterations occur in fish.…”

mentioning

confidence: 56%

Phagocytosis of the inert suspended clay kaolin by the gills of rainbow trout, Salmo gairdneri Richardson

Goldes

Ferguson

Daoust

et al. 1986

Journal of Fish Diseases

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mentioning

confidence: 56%

Phagocytosis of the inert suspended clay kaolin by the gills of rainbow trout, Salmo gairdneri Richardson

Goldes

Ferguson

Daoust

et al. 1986

Journal of Fish Diseases

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“… Davies et al (1984) exposed rats to SVF aerosols at 10 mg/m 3 for 7 h/d, 5 d/wk for 1 yr as compared to the single exposure of several hours duration used by Morgan and Holmes (1984) . The percentage of glass fibers with diameters less than 0.3 μm recovered from the lungs was consistently less than that in the original fiber suspension, and the reduction was more marked in the animals that were sacrificed following a period of recovery from the exposures than from those sacrificed at the end of the exposure.…”

Section: Role Of Fiber Retention In Biological Responses Of Various Amentioning

confidence: 99%

Pulmonary Endpoints (Lung Carcinomas and Asbestosis) Following Inhalation Exposure to Asbestos

Mossman

Lippmann

Hesterberg

et al. 2011

Journal of Toxicology and Environmental Health, Part B

187

164

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Lung carcinomas and pulmonary fibrosis (asbestosis) occur in asbestos workers. Understanding the pathogenesis of these diseases is complicated because of potential confounding factors, such as smoking, which is not a risk factor in mesothelioma. The modes of action (MOA) of various types of asbestos in the development of lung cancers, asbestosis, and mesotheliomas appear to be different. Moreover, asbestos fibers may act differentially at various stages of these diseases, and have different potencies as compared to other naturally occurring and synthetic fibers. This literature review describes patterns of deposition and retention of various types of asbestos and other fibers after inhalation, methods of translocation within the lung, and dissolution of various fiber types in lung compartments and cells in vitro. Comprehensive dose-response studies at fiber concentrations inhaled by humans as well as bivariate size distributions (lengths and widths), types, and sources of fibers are rarely defined in published studies and are needed. Species-specific responses may occur. Mechanistic studies have some of these limitations, but have suggested that changes in gene expression (either fiber-catalyzed directly or by cell elaboration of oxidants), epigenetic changes, and receptor-mediated or other intracellular signaling cascades may play roles in various stages of the development of lung cancers or asbestosis.

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“…In general the authors concluded that mica has a low cytotoxicity. Kaolinite, with minor contamination of quartz and mica, is cytotoxic to mouse macrophages, although not as actively so as pure quartz (Davis et al, 1984). Results of experiments exposing rat lungs to kaolin have been inconclusive, with some minimal reticulin response (King et al, 1948), and evidence of minimal interstitial fibrosis after 2 0 0 + days exposure (Sheers, 1989).…”

Section: The Potential Health Effects Of Inhaling China Clay Mining-dmentioning

confidence: 99%

Airborne particulate matter (PM₁₀) in the china clay area, Cornwall, UK

et al. 2003

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Work was undertaken in 1997 as part of a UK government programme to monitor air quality in the Cornish china clay area. These studies showed that concentrations of airborne particulate matter with an aerodynamic diameter <10 μm (PM10) did not exceed UK National Air Quality Strategy (NAQS, 1995) guidelines but were, however, greater than those normally associated with rural areas. Subsequently, in the summer of 2000, airborne dust sampling was conducted at three sites around the IMERYS (formerly ECCI) Kernick mica dam, a potential source of resuspended airborne particulates from china clay waste minerals. Analytical scanning electron microscopy examination of the collected material suggested that up to 61% of the airborne PM10 monitored next to the mica dam could be associated with china clay extraction compared with 46% 2 km to the south. Results showed the presence of substantial percentages of respirable kaolinite, muscovite and quartz; the major components of china clay waste. The health effects of the particular mineral dust emissions associated with china clay mining are reviewed.

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Factors Involved in the Cytotoxicity of Kaolinite towards Macrophages in Vitro

Cited by 5 publications

References 2 publications

Phagocytosis of the inert suspended clay kaolin by the gills of rainbow trout, Salmo gairdneri Richardson

Phagocytosis of the inert suspended clay kaolin by the gills of rainbow trout, Salmo gairdneri Richardson

Pulmonary Endpoints (Lung Carcinomas and Asbestosis) Following Inhalation Exposure to Asbestos

Airborne particulate matter (PM₁₀) in the china clay area, Cornwall, UK

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Factors Involved in the Cytotoxicity of Kaolinite towards Macrophages in Vitro

Cited by 5 publications

References 2 publications

Phagocytosis of the inert suspended clay kaolin by the gills of rainbow trout, Salmo gairdneri Richardson

Phagocytosis of the inert suspended clay kaolin by the gills of rainbow trout, Salmo gairdneri Richardson

Pulmonary Endpoints (Lung Carcinomas and Asbestosis) Following Inhalation Exposure to Asbestos

Airborne particulate matter (PM10) in the china clay area, Cornwall, UK

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Airborne particulate matter (PM₁₀) in the china clay area, Cornwall, UK