Poly(2-vinylpyridine 1-oxide), when injected into animals, counteracts the pathogenic effects of inhaled silica dust. To study its distribution in the cells, a specifically labelled polymer has been synthesised by reducing 2-acetylpyridine with tritium, dehydrating, polymerising then oxidizing the polyvinyl product. Some of the tritium (17 yo) enters the aromatic ring by exchange and there is a small loss of tritium by exchange with solvents.A t the stage of reduction, there is preference for C-T bond formation rather then C-H. ZUSAMMENFASSUNG:In Tiere injiziertes Poly-(2-vinylpyridin-l-oxid) verhindert die pathogenen Effekte von inhaliertem Siliciumdioxid-Staub. Um die Verteilung in den Zellen zu studieren, wurde ein spezifisch markiertes Polymeres durch Reduktion von 2-Acetylpyridin mit Tritium, Dehydratisierung, anschlieaender Polymerisation und Oxydation des Polyvinylprodukts hergestellt. Ein Ted des Tritiums (17 %) wird durch Austausch in den aromatischen Ring eingebaut, ein kleiner Teil geht durch Austausch mit den Losungsmitteln verloren. Bei der Reduktionsstufe werden mehr C-T-als C-H-Bindungen gebildet.
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