Polarographic Investigations of Quinoxaline‐N‐oxides

Horn, G.; Schulze, Werner; Tresselt, D.

doi:10.1002/prac.19853270123

Cited by 10 publications

(9 citation statements)

References 3 publications

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“…In literature, are reported several examples of specific reactions on the substituents of the pyrazine ring of QdNO's: aminolysis with primary amines [142], indirect hydrolysis [160], azidolysis [177], acetylation, alkylation and deamination [104], simultaneous deacylation and hydrolysis of carboxylic esters [169], decarboxylation [178].…”

Section: ) Reactions Involving Substituents Of Pyrazine Ringmentioning

confidence: 99%

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Quinoxaline 1,4-Dioxide: A Versatile Scaffold Endowed With Manifold Activities

Carta

Corona²,

Loriga

2005

CMC

136

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Since 1940s, Quinoxaline 1,4-dioxides (QdNO's) are known as potent antibacterial agents, and subtherapeutic levels have been used to promote growth and improve efficiency of feed conversion in animal feed. They have also shown a selective cytotoxicity against hypoxic cells present in solid tumours. Furthermore, recent studies have put in evidence that QdNO's are endowed with antitubercular, antiprotozoal and anticandida activities. On the other hand, several authors have reported about photoallergic and mutagenic effects of some derivatives. QdNO's may also cause the development of antibiotic-resistant bacteria and influence the horizontal transfer of virulence genes between bacteria. In this review article we report the biological properties, the mode of action and Structure Activity Relationship (SAR) studies of the QdNO derivatives. Furthermore, some cytogenetic and genotoxic effects, classical and more recent method of synthesis, the quinoxaline 1,4-dioxides, and some of their most important reactions, were also reported.

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Section: ) Reactions Involving Substituents Of Pyrazine Ringmentioning

confidence: 99%

“…Reduction of QdNO's has been accomplished by a variety of reducing agents like Trimethyl Phosphate, Sodium Hypophosphate, Sodium Bisulfite, Sodium Dithionite, Titanium (III) Chloride, Catalytic Hydrogenation, Ascorbic Acid, etc. [131,[160][161][162][163][164][165][166][167][168][169]. In Fig.…”

Section: ) Deoxygenation Reactionsmentioning

confidence: 99%

Quinoxaline 1,4-Dioxide: A Versatile Scaffold Endowed With Manifold Activities

Carta

Corona²,

Loriga

2005

CMC

136

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“…Much of our present understanding of the thermodynamic and mechanical properties of nonpolar fluids under nanometers confinement comes from extensive experimental studies during the past decades by the surface force apparatus (SFA) or surface force balance (SFB) instruments. [1][2][3][4][5][6] In these studies a small amount of fluid was put into a cross-cylinder confined geometry between two macroscopic mica surfaces. The lateral dimension of the cross-cylinder contact geometry could be as large as many microns.…”

Section: Introductionmentioning

confidence: 99%

Computational simulations of solvation force and squeezing out of dodecane chain molecules in an atomic force microscope

Xiang

Leng

2017

The Journal of Chemical Physics

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Understanding the squeeze out behaviors of liquid films at nanometer scale in an atomic force microscope (AFM) has been a significant interest since the 1990s. We carry out all-atom static-mode AFM simulations in a liquid-vapor molecular dynamics ensemble to investigate the solvation force oscillation and squeeze out mechanisms of a confined linear dodecane fluid between a gold AFM tip and a mica substrate. Solvation force oscillations are found to be associated with the layering transition of the liquid film and unstable jumps of the AFM tip. Detailed structural analyses and molecular animations show that the local permeation of chain molecules and the squeeze out of molecules near the edge of contact promote the layering transition under compression. The confinement-induced slow down dynamics is manifested by the decrease in diffusivity and increase in rotational relaxation times. However, the persistent diffusive behavior of dodecane chain molecules even in the single-monolayer film is attributed to the chain sliding motions in the film due to the substantial vacancy space and thermal fluctuations.

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“…For confined systems, some anomalous liquids also present layering transition 40 , superflow [41][42][43][44] and distinct dynamic behavior [45][46][47] . Oscillations in the solvation force 48 and a dramatic increase of the viscosity can occur in ultrathin confined fluids 49 .…”

Section: Introductionmentioning

confidence: 99%

New Structural Anomaly Induced by Nanoconfinement

2014

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We explore the structural properties of anomalous fluids confined in a nanopore using molecular dynamics simulations. The fluid is modeled by core-softened (CS) potentials that have a repulsive shoulder and an attractive well at a further distance. Changing the attractive well depth of the fluid-fluid interaction potential, we studied the behavior of the anomalies in the translational order parameter t and excess entropy s(2) for the particles near to the nanopore wall (contact layer) for systems with two or three layers of particles. When the attractive well of the CS potential is shallow, the systems present a three to two layers transition and, additionally to the usual structural anomaly, a new anomalous region in t and s(2). For attractive well deep enough, the systems change from three layers to a bulk-like profile and just one region of anomaly in t and s(2) is observed. Our results are discussed on the basis of the fluid-fluid and fluid-surface interactions.

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Polarographic Investigations of Quinoxaline‐N‐oxides

Cited by 10 publications

References 3 publications

Quinoxaline 1,4-Dioxide: A Versatile Scaffold Endowed With Manifold Activities

Quinoxaline 1,4-Dioxide: A Versatile Scaffold Endowed With Manifold Activities

Computational simulations of solvation force and squeezing out of dodecane chain molecules in an atomic force microscope

New Structural Anomaly Induced by Nanoconfinement

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