Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part V: Histologic evaluations of PRF effects on bone allograft maturation in sinus lift

Choukroun, Joseph; Diss, Antoine; Simonpieri, Alain; Girard, M.-O.; Schoeffler, C.; Dohan, S.; Dohan, Anthony; Mouhyi, Jaafar; Dohan, D.

doi:10.1016/j.tripleo.2005.07.012

Cited by 571 publications

(528 citation statements)

References 26 publications

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“…It also has the additional benefit of preserving ridge width and height at intervals of 90 to 180 days 54) . Choukroun et al 15) Implants and Chronic Periapical Infection reported faster healing with leukocyte-PRF mixed with DFDBA after sinus lift (4 months) than with DFDBA alone (8 months). In an experimental rabbit model, the combination of PRF and DFDBA yielded the highest boneimplant contact (73.43±3.86%) and percentage of new bone formation (63.09±2.10%) at the defect area when compared with antibiotic or saline.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, BMPs act primarily at the later stages of osteoinduction, such during mesenchymal cell differentiation and vascular proliferation. Platelet-rich fibrin entraps circulating stem cells, resulting in superior healing of large osseous defects where there is migration of stem cells differentiating into the osteoblast phenotype 15) . Combining graft materials such as DFDBA with PRF enables these two distinct wound healing processes to take place concurrently.…”

Section: Discussionmentioning

confidence: 99%

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Effect of PRF and Allograft Use on Immediate Implants at Extraction Sockets with Periapical Infection —Clinical and Cone Beam CT Findings—

Medikeri

Meharwade

Wate

et al. 2018

Bull. Tokyo Dent. Coll.

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Immediate implant placement can be successful, even at infected sites. The adjunctive effects of concomitant use of platelet-rich fibrin (PRF) and decalcified freeze-dried bone allografts (DFDBA) at periapically infected sites remains to be determined, however. The purpose of this prospective study was to investigate the effect of combined use of PRF and DFDBA on immediate implant survival at tooth extraction sites exhibiting periapical lesions. Implants were immediately placed in 8 patients under a standard chemotherapeutic protocol. Adin titanium implants were used in all cases. The combination of PRF and DFDBA was used to fill the gap between the implant body and the surrounding socket wall. The final restoration was placed after 3 months. The full-mouth plaque, gingival bleeding index, and gingival esthetics scores were assessed at 3, 6, and 12 months. Cone beam computed tomography images obtained at baseline and at 12 months after implant loading were analyzed. The plaque index scores showed statistically significant differences at 3, 6, and 12 months (p<0.05). The gingival bleeding index score showed no significant difference. No difference was noted in buccal gingival level on the implant surface or adjacent teeth at 91.7% of sites. Complete closure of the interproximal space was seen in 91.7% of the implant sites. Crestal bone levels on all implant surfaces were non-significant. Implant survival was 91.67% at 12 months. The adjunctive use of PRF with DFDBA at periapically infected sites yielded a significant reduction in bone resorption and accelerated bone healing during the initial post-extraction stage. A significant improvement was achieved in the gingival esthetic score at the interproximal and midfacial surfaces. The combined use of growth factors with pre-and postoperative broadspectrum antibiotics over a short time resulted in a higher implant survival rate at the end of the 1 year post-restoration period.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of PRF and Allograft Use on Immediate Implants at Extraction Sockets with Periapical Infection —Clinical and Cone Beam CT Findings—

Medikeri

Meharwade

Wate

et al. 2018

Bull. Tokyo Dent. Coll.

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“…The palatal mucoperiosteal flaps were reflected and sutured to each other to repair the palatal mucosa of palatal side of the cleft if needed. During preparation of the recipient site, in group I the required amount of blood was aspirated and centrifuged for PRF preparation according to Choukroun's method [17][18][19] and beside that the required amount of bone marrow was aspirated from the ilium. PRF gel (4-6 ml) and bone marrow aspirate (1-2 ml) were mixed with a mount of β-Tricalcium phosphate granules, according to size of defect and placed in recipient bed.…”

Section: Operative Proceduresmentioning

confidence: 99%

Effect of Platelet-Rich Fibrin on The Regeneration Capacity of Bone Marrow Aspirate In Alveolar Cleft Grafting (Clinical and Radiographic Study)

Al-Ashmawy¹,

Ali²,

Baiomy³

2017

Dentistry

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The present study aimed to evaluate the enhancing effect of platelet-rich fibrin (PRF) on autogenous bone marrow aspirate (BMA) using in a resorbable matrix for repair of alveolar cleft defects. It was conducted on 12 patients (7 males and 5 females) with unilateral alveolar cleft and oronasal leakage. They divided into two random equal groups (group I and II). In group I, alveolar cleft defect packed with a mixture of PRF, β-Tricalcium phosphate, and BMA, and the same mixture without PRF for group II. Our clinical results revealed that, all patients had uneventful wound healing except some cases in group II. While, densitometric analysis showed a high statistical significant difference between two groups (p=0.011737) at 6 months interval but, at 12 months interval difference was not statistically significant (p=0.142480). Also, volumetric measurements of new bone showed that, there was highly statistical significant difference (p=0.037997) between group I and II at 12 month interval. The present study concluded that PRF may enhance the regeneration capacity of the stem cells when it added to BMA. Thereby, they may accelerate bone regeneration in alveolar cleft defects. Moreover, it may be used as membrane to cover grafted alveolar defect.

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“…5 PRF applications have been implemented in many areas of oral surgery, such as dental implantology, sinus lift procedures, and cyst surgeries. [7][8][9] However, there are only few studies regarding the effect of PRF on complications following third molar surgery. 4,10 The aim of this study was to evaluate the effect of PRF on postoperative pain, swelling, and trismus following impacted third molar surgery.…”

Section: Introductionmentioning

confidence: 99%

Trombositten zengin fibrinin gömülü yirmi yaş dişi cerrahisi sonrası postoperatif komplikasyonların azaltılmasına etkisi: prospektif, randomize kontrollü klinik araştırma

Esen¹,

Menziletoğlu²,

Işık³

2016

Acta Odontologica Turcica

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Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part V: Histologic evaluations of PRF effects on bone allograft maturation in sinus lift

Cited by 571 publications

References 26 publications

Effect of PRF and Allograft Use on Immediate Implants at Extraction Sockets with Periapical Infection —Clinical and Cone Beam CT Findings—

Effect of PRF and Allograft Use on Immediate Implants at Extraction Sockets with Periapical Infection —Clinical and Cone Beam CT Findings—

Effect of Platelet-Rich Fibrin on The Regeneration Capacity of Bone Marrow Aspirate In Alveolar Cleft Grafting (Clinical and Radiographic Study)

Trombositten zengin fibrinin gömülü yirmi yaş dişi cerrahisi sonrası postoperatif komplikasyonların azaltılmasına etkisi: prospektif, randomize kontrollü klinik araştırma

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