Effect of PRF and Allograft Use on Immediate Implants at Extraction Sockets with Periapical Infection —Clinical and Cone Beam CT Findings—

Abstract

Immediate implant placement can be successful, even at infected sites. The adjunctive effects of concomitant use of platelet-rich fibrin (PRF) and decalcified freeze-dried bone allografts (DFDBA) at periapically infected sites remains to be determined, however. The purpose of this prospective study was to investigate the effect of combined use of PRF and DFDBA on immediate implant survival at tooth extraction sites exhibiting periapical lesions. Implants were immediately placed in 8 patients under a standard chemotherapeutic protocol. Adin titanium implants were used in all cases. The combination of PRF and DFDBA was used to fill the gap between the implant body and the surrounding socket wall. The final restoration was placed after 3 months. The full-mouth plaque, gingival bleeding index, and gingival esthetics scores were assessed at 3, 6, and 12 months. Cone beam computed tomography images obtained at baseline and at 12 months after implant loading were analyzed. The plaque index scores showed statistically significant differences at 3, 6, and 12 months (p<0.05). The gingival bleeding index score showed no significant difference. No difference was noted in buccal gingival level on the implant surface or adjacent teeth at 91.7% of sites. Complete closure of the interproximal space was seen in 91.7% of the implant sites. Crestal bone levels on all implant surfaces were non-significant. Implant survival was 91.67% at 12 months. The adjunctive use of PRF with DFDBA at periapically infected sites yielded a significant reduction in bone resorption and accelerated bone healing during the initial post-extraction stage. A significant improvement was achieved in the gingival esthetic score at the interproximal and midfacial surfaces. The combined use of growth factors with pre-and postoperative broadspectrum antibiotics over a short time resulted in a higher implant survival rate at the end of the 1 year post-restoration period.

Evaluation of Mineralized Plasmatic Matrix as a grafting material around immediate dental implant in mandibular posterior teeth

“…Regarding postoperative infection, our result is in agreement with Medikeri et al They found combined use of growth factors with pre-and postoperative broadspectrum antibiotics over a short time resulted in a higher implant survival rate in infected site. Hoaglin et al found that we can Prevent localized osteitis in mandibular third molar sites using platelet rich fibrin (14,15) . Results of the present study have a statisticvally non-significant difference in mean of facial edema during the postoperative three months, indicate that using MPM has significant effect on the postoperative edema following dental implant surgery.…”

Prosthodontic Management of Single Anterior Missing Tooth with Immediate Loading Implant Using Leukocyte-Platelet-Rich Fibrin

“…In the present study, PRF, a platelet concentrate, was used as a source of growth factors to accelerate the initial stages of wound healing. 11 L-PRF is a second generation of autologous platelet concentration and a fibrin mesh consisting of leukocytes, growth factors, proteins, and cytokines.…”

Periodontal regeneration by leukocyte and platelet‐rich fibrin with autogenous bone graft versus enamel matrix derivative with autogenous bone graft in the treatment of periodontal intrabony defects: A randomized non‐inferiority trial

“…To refer the whole effects to BAs could seem reasonable, yet some hypotheses suggest that the application of an L‐PRF membrane onto the graft in the TSs could have contributed to the graft and blood clot stabilization, retaining them within the walls of the IBD 32 in the early phases of the healing process and favoring the defect's healing also through a mechanism independent from the BAs’ biological properties. However, it is true that in meta‐analyses 9,33 EMD showed not to take advantage for IBDs healing from the simultaneous membrane application.…”