Plasma Insulin Response to 72-Hr. Avoidance Sessions in the Monkey

Mason, John W.; Wherry, Frances E.; Brady, Joseph V.; Beer, Bernard; Pennington, Lee L.; Goodman, Anita C.

doi:10.1097/00006842-196809000-00030

Cited by 18 publications

(9 citation statements)

References 29 publications

(16 reference statements)

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“…The large fall in IRI values for these animals lies far outside the range of determinations for hyperinsulinemic monkeys in our colony (mean 594 ± 70 yuU/ml serum) (3). These results with hyperinsulinemic monkeys are similar to the data of Mason et al (10) with normoinsulinemic monkeys exposed to shock avoidance procedures. In that work, monkeys were trained to avoid electric shock to the feet.…”

Section: Discussionsupporting

confidence: 90%

Social Interaction and Serum Insulin Values in The Monkey (Macaca Mulatta)

Hamilton

Chaddock

1977

Psychosomatic Medicine

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Social interaction studies were conducted with two groups of rhesus monkeys with abnormally elevated serum insulin values. In both studies, the animals that were lowest on the dominance-submissiveness scale showed a fall in insulin levels to within the normal range for the monkey. Upon removal from the group, insulin values in these animals returned to their previous elevated level. In neither instance was the fall in insulin level accompanied by fasting hyperglycemia.

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Section: Discussionsupporting

confidence: 90%

Social Interaction and Serum Insulin Values in The Monkey (Macaca Mulatta)

Hamilton

Chaddock

1977

Psychosomatic Medicine

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“…Indications are that corticosterone responses to initial stimulation sessions may attenuate the effect of STZ on the /3 cells in islets. Further study of stimulation-induced changes in adrenocortical activity, catecholamine levels, and other humoral factors (22)(23)(24) in STZ-injected animals should provide a better understanding of the mechanism by which the stimulation inhibits the development of IDD.…”

Section: Discussionmentioning

confidence: 99%

Effect of Stressful Stimulation on the Incidence of Streptozotocin-Induced Diabetes in Mice1

Huang¹,

Sm²,

Taylor³

et al. 1981

Psychosomatic Medicine

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In three experiments, groups of 8-18, 45-day-old male CD-1 mice were injected with a single dose of streptozotocin (STZ) and were followed for 12-31 weeks. Experimental groups were given periodic. light-shock stimulation beginning at various times after streptozotocin injection. Blood samples were taken biweekly from all mice. Blood glucose levels were attenuated over a 22 week period in mice that were stimulated during the first 72 hours after STZ injection. Incidence of insulin-dependent diabetes (blood glucose levels over 150 mg%) was also significantly reduced in stimulated mice. Progressively increasing correlations between sampling order and blood glucose levels, which were significant over the last 12 weeks of one experiment, indicated that blood glucose levels of caged, diabetic mice responded markedly to laboratory procedures.

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“…This linkage presumably could provide a pathway for neural or psychological influences on the anterior pituitary hormones, adrenocorticotropin, thyrotropin, the gonadotropins, growth hormone, and prolactin. 34 Since reliable radioimmunochemical assays have recently become available, apparently the problem has not as yet been systematically re-evaluated. 7 -n -1 T There is also increasing physiological evidence of neural influences upon the secretion of prolactin 9 ' 35 and growth hormone.…”

Section: Neuroanatomical Factorsmentioning

confidence: 99%