Plasma Aldosterone, Cortisol and Electrolyte Concentrations in Physical Exercise after Magnesium Supplementation

Abstract

Plasma aldosterone, cortisol, sodium (Na), potassium (K), calcium (Ca), magnesium (Mg) äs well äs urine and sweat Na, K, Ca and Mg concentrations were measured in nine male healthy persons during an one hour ergometer exercise before and after a fourteen day magnesium aspartate (Mg) Supplementation. The usual aldosterone and cortisol increase during exercise was not observed and cortisol concentration was significantly lowef after Mg Supplementation. Na and K in plasma increased during the exercise; these changes were not affected by Mg. The Mg concentration was elevated in plasma and erythrocytes after Mg Supplementation. During the ergometer course plasma Mg was unchanged but decreased significantly in the red blood cells. Mg and K concentration in sweat decreased during the exercise. No influence of Mg on urinary electrolyte excretion was observed. Aldosteron-, Cortisol" und Elektrolytkonzentrationen im Plasma bei körperlicher Belastung unter Magnesium-SubstitutionZusammenfassung: Die Konzentrationen von Cortisol, Aldosteron, Natrium (Na), Kalium (K), Calcium (Ca) und Magnesium (Mg) im Plasma sowie die Konzentrationen von Na, K, Ca und Mg im Urin und Schweiß wurden bei neun männlichen, gesunden Personen vor und nach einer 14tägigen Substitution mit Magnesium-Aspartat (Mg) während einer einstündigen Ergometerbelastung gemessen. Der üblicherweise während einer körperlichen Belastung gefundene Anstieg des Aldosterons und Cortisols im Plasma wurde bei den mit Magnesium substituierten Personen nicht gefunden. Die Cortisol-Konzentration im Plasma war nach der Mg-Substitution signifikant niedriger. Na und K im Plasma stiegen während der Belastung unabhängig von der Mg-Substitution an. Die Mg-Konzentf ation im Plasma und in den Erythrocyten stieg unter der Mg-Substitutron an. Während der Ergometerbelastung änderte sich die Mg-Konzentration im Plasma nicht, während sie in den roten Blützellen signifikant abfiel. Die Konzentrationen von Mg und K im Schweiß sanken während der Belastung. Ein Einfluß der Mg-Substitütion auf die Elektrolytausscheidung im Urin wurde nicht beobachtet. *) This paper will be part of the doctoral thesis of O. Happel.ing exercise (6).

Minerals: Exercise performance and supplementation in athletes*

“…Magnesium supplementation (15 mmol magnesium-L-aspartate-hydrochloride) taken daily for 14 days produced a change in hormonal response to a 1 h ergometric exercise (Golf et al, 1984). Specifically, aldosterone and cortisol did not increase in response to the exercise after the supplementation period.…”

The effect of diet components on the level of cortisol

“…In studies of Golf et al, it was demonstrated that this process can be limited by supplementation of athletes' diet with magnesium. After completion of the 14-day cycle of supplementation with 15 mol of magnesium was recorded lack of exercise-induced increase in cortisol level [59]. Action of magnesium is explained by its inhibitory activity on NMDA (N-metil-d-aspartate) receptor, which leads to reduction in adrenocorticotropin secretion by anterior pituitary and to inhibition of cortisol synthesis at the stage of conversion of cholesterol to pregnenolone [60].…”

Consequences of magnesium deficiency on the enhancement of stress reactions; preventive and therapeutic implications (a review).

“…Elevation of plasma CS and increased urinary excretion of CS and its metabolites have been reported in monkeys subjected to anxiety or aggression [7], and in humans under emotional and physical stresses [2,[8][9][10].…”

“…Plasma Mg was unchanged, but rbc Mg decreased sig nificantly during exercise on an ergometer in a study by Golf et al [10]. Boehmer [220], however, found that an hour's strenuous exercise sharply lowered serum Mg in a large group of well-trained athletes whose resting serum Mg values were normal.…”