Plaque formation and gingivitis after mouthrinsing with 0.2% delmopinol hydrochloride, 0.2% chlorhexidine digluconate and placebo for 4 weeks, following an initial professional tooth cleaning

Abstract

A double-blind, randomised, 4-week clinical trial with parallel group design in 57 patients with gingivitis was conducted for studying the antibacterial efficacy and safety of a delmopinol HCl aqueous solution 2 mg/ml (0.2% w/v), which was used for unsupervised mouth-rinsing and compared with placebo and chlorhexidine digluconate 2 mg/ml (0.2% w/v, Hibitane Dental, ICI Pharmaceuticals, UK). The plaque index and plaque wet weight were used to measure plaque formation, and gingival fluid flow and bleeding on probing to measure gingivitis. According to the reduction from baseline, chlorhexidine showed a significantly better effect on plaque formation than the placebo after 4 weeks treatment for both plaque measurements. Delmopinol exhibited significantly lower plaque index scores than placebo. The difference between chlorhexidine and delmopinol was not statistically significant for any of the plaque measurements. For gingivitis, no statistically significant differences were obtained between the effects of delmopinol, chlorhexidine and placebo. A transient anaesthetic sensation in the oral mucosa was experienced more clearly by the patients in the delmopinol group than by those using chlorhexidine or placebo rinses. Rinsing with chlorhexidine resulted in more staining of the teeth and tongue than did delmopinol and placebo. The placebo solution tasted better than the 2 active solutions. The results showed that rinsing with either delmopinol HCl aqueous solution 2 mg/ml or chlorhexidine digluconate 2 mg/ml 2x daily for 60 as a supplement to normal oral hygiene, following an initial professional tooth cleaning, leads to a lower plaque formation than rinsing with placebo.(ABSTRACT TRUNCATED AT 250 WORDS)

6‐month use of 0.2% delmopinol hydrochloride in comparison with 0.2% chlorhexidine digluconate and placebo

“…No serious adverse events were reported in this study. As in previous studies (Collaert et al 1992a, b, 1993a, b, 1994, Moran et al, 1992, Rundegren et al, 1992a, Hase et al 1995a, b, Claydon et al 1996, Klinge et al 1996, a transient anaesthetic sensation, especially located at the tip of the tongue, was the dominant adverse event reported in the delmopinol group. At the 6-month examination, however, this side-effect was reported with the same frequency also in the chlorhexidine group.…”

A Systematic Review on the Effects of the Chlorhexidine Chip When Used as an Adjunct to Scaling and Root Planing in the Treatment of Chronic Periodontitis

“…All search strategies resulted in the identification of 54 publications. Independent screening by two reviewers (JC and IW) led to the rejection of 49 articles for the following reasons: only abstract and no full‐text available; 35‐40 follow‐up instead of randomized controlled study; 41,42 case series instead of randomized controlled study; 43 interim reports presenting preliminary data that are also implemented in larger studies; 44,45 published in Chinese; 46 evaluation of other treatment regimens; 47‐68 administration of the first generation slow‐release non‐degradable chip; 26‐28,30 use of the CHX chip prior to periodontal regeneration; 69 application of the CHX chip during supportive periodontal care; 70,71 pharmacokinetic evaluation of the CHX chip; 31,32 report describing ease of use of the chip; 72 economic evaluation of a CHX chip implemented treatment strategy; 73,74 and narrative reviews 75‐77 …”

Adjunctive effect of mouthrinse on treatment of peri‐implant mucositis using mechanical debridement: A randomized clinical trial

“…While previous studies examined the role of delmopinol mouthrinse in controlling dental plaque, gingivitis and in improving periodontal health around natural teeth (Hase, Ainamo, Etemadzadeh, & Aström, 1995; Lang et al., 1998) this present study examined the effects of 0.2% delmopinol mouthrinse on a target implant and full mouth. Novel findings from the current study were that delmopinol mouthrinse use resulted in statistically significant reductions in bleeding on probing and gingivitis on both dental implants and full mouth.…”