Plants and phytochemicals for treatment of peptic ulcer: An overview

Gupta, Manohar Lal; Kapoor, Bhupinder; Gupta, Reena; Singh, Naresh

doi:10.1016/j.sajb.2020.11.030

Cited by 15 publications

(9 citation statements)

References 133 publications

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“…Various other triterpenoids including epifriedelin and β-amyrin have also been detected in smaller amounts [41,45,93]. Friedelin have shown various biological activities including antiulcer, antidiabetic and cytotoxic effects [94][95][96] while β-amyrin have been associated with anti-microbial, anti-fungal properties and a potential anti-inflammatory activity [97]. To our knowledge, no biological activities have been reported for epifriedelin.…”

Section: The Terpenes Present In Cannabis Sativa L and Their Biologic...mentioning

confidence: 99%

Extraction of Phenolic Compounds and Terpenes from Cannabis sativa L. By-Products: From Conventional to Intensified Processes

2021

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Cannabis sativa L. is a controversial crop due to its high tetrahydrocannabinol content varieties; however, the hemp varieties get an increased interest. This paper describes (i) the main categories of phenolic compounds (flavonoids, stilbenoids and lignans) and terpenes (monoterpenes and sesquiterpenes) from C. sativa by-products and their biological activities and (ii) the main extraction techniques for their recovery. It includes not only common techniques such as conventional solvent extraction, and hydrodistillation, but also intensification and emerging techniques such as ultrasound-assisted extraction or supercritical CO2 extraction. The effect of the operating conditions on the yield and composition of these categories of phenolic compounds and terpenes was discussed. A thorough investigation of innovative extraction techniques is indeed crucial for the extraction of phenolic compounds and terpenes from cannabis toward a sustainable industrial valorization of the whole plant.

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Section: The Terpenes Present In Cannabis Sativa L and Their Biologic...mentioning

confidence: 99%

Extraction of Phenolic Compounds and Terpenes from Cannabis sativa L. By-Products: From Conventional to Intensified Processes

2021

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“…The health benefits of ginger are attributed to numerous biological components, including gingerols, gingerdiols, shogaols, paradols, and zingerones. Further, shogaol, a primary active ingredient of ginger, exists in various forms such as 4-, 6-, 8-, 10-, and 12-shogaol (Gupta et al 2021). Guo et al (2021) investigated the therapeutic action of ginger in DSS-induced UC in male BALB/c mice and reported that ginger alleviated colitis-associated pathological Fig.…”

Section: Shagoalmentioning

confidence: 99%

Section: Herbal Approaches For the Treatment Of Ulcerative Colitismentioning

confidence: 99%

Natural compounds as safe therapeutic options for ulcerative colitis

et al. 2022

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Ulcerative colitis (UC) is a chronic inflammatory bowel disease of unknown etiology. Several conventional treatments for UC such as corticosteroids, immunosuppressive agents, tumor necrosis factor antagonist, integrin blockers, and interleukin antagonist, and salicylates are available but are associated with the various limitations and side-effects. None of the above treatments helps to achieve the ultimate goal of the therapy, i.e., maintenance of remission in the long-term. Natural remedies for the treatment of UC show comparatively less side effects as compared to conventional approaches, and affordable. The current review presents details on the role of herbal drugs in the treatment and cure of UC. Google, PubMed, Web of Science, and Scopus portals have been searched for potentially relevant literature to get the latest developments and updated information related to use of natural drugs in the treatment of UC. Natural products have been used over centuries to treat UC. Some of the essential herbal constituents exhibiting antiulcerogenic activity include gymnemic acid (Gymnema sylvestre), shagoal (Zingiber officinale), catechin (Camellia sinensis), curcumin (Curcuma longa), arctigenin (Arctium lappa), and boswellic acid (Boswellia serrata). Although many plant-derived products have been recommended for UC, further research to understand the exact molecular mechanism is still warranted to establish their usefulness clinically.

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“…The observed effect of reduced gastric acid output suggests that T. occidentalis leaf extract may exert its effect via the histamine receptor pathway. Some studies have reported that plant phytochemicals can reduce gastric acid secretion through histamine receptor inhibition 23,24 .…”

Section: Effect Of Telfairia Occidentalis On Intestinal Transit and M...mentioning

confidence: 99%

Aqueous Leaves Extract of Telfairia occidentalis (Fluted Pumpkin) Protects Against Gastric Ulcer and Inhibits Intestinal Motility in Wistar Rats

Basse¹,

Oko²,

Bes³

et al. 2022

J. of Applied Sciences

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Background and Objective: Telfairia occidentalis (fluted pumpkin) leaves are consumed extensively in Nigeria and it contains many beneficial nutrients that enhance good health. This study investigated the effect of Telfairia occidentalis (TO) on gastric acid secretion and intestinal motility in Wistar rats. Materials and Methods: Adult Wistar rats (180-200 g) were divided into the control group that were fed rat chow and TO group that received 200 mg kgG 1 T. occidentalis aqueous leaf extract by gavage method daily for 14 days. The third group was administered with ranitidine (50 mg kgG 1 ) intraperitoneally. Results: Mean basal acid output and histamine-stimulated gastric acid output by continuous perfusion in the TO group was significantly decreased compared with the control. Mean total acid output by pyloric ligation showed a significant (p<0.01) decrease in TO and ranitidine-treated groups compared with control. Ranitidine (50 mg kgG 1 ) reduced gastric acid secretion significantly (p<0.05) in the TO group compared with the control. The pepsin activity, adherent mucus weight, ulcer score and transit in Telfairia occidentalis and ranitidine-treated groups were comparable with the control. Conclusion: These results suggest that Telfairia occidentalis at 200 mg kgG 1 has cytoprotection against gastric ulcers and inhibits intestinal motility in rats which may probably be attributed to the phytochemicals present in the plant extract.

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Plants and phytochemicals for treatment of peptic ulcer: An overview

Cited by 15 publications

References 133 publications

Extraction of Phenolic Compounds and Terpenes from Cannabis sativa L. By-Products: From Conventional to Intensified Processes

Extraction of Phenolic Compounds and Terpenes from Cannabis sativa L. By-Products: From Conventional to Intensified Processes

Natural compounds as safe therapeutic options for ulcerative colitis

Aqueous Leaves Extract of Telfairia occidentalis (Fluted Pumpkin) Protects Against Gastric Ulcer and Inhibits Intestinal Motility in Wistar Rats

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