Aqueous Leaves Extract of Telfairia occidentalis (Fluted Pumpkin) Protects Against Gastric Ulcer and Inhibits Intestinal Motility in Wistar Rats

Basse, Irene Okon; Oko, Idara Asuquo; Bes, Justin Atiang; Umo, Elizabeth Bassey; Owu, Daniel U.

doi:10.3923/jas.2022.92.99

Cited by 2 publications

(1 citation statement)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fluted pumpkin methanol leaf extract is said to possess antioxidant activities capable of protecting against lipid peroxidation and cell damage in the ovary of female Albino rats. The ethanol leaf extract of fluted pumpkin is rich in bioactive compounds of pharmacological importance such as tannins, flavonoids, saponins, alkaloids, terpenoids and cardiac glycosides which act to reduce blood glucose level in diabetic rats [11] [12]. Telfaria occidentalis is reported to be used in ethnobotany as antidiabetic, antitumor, antihypertensive, antiparasitic and antibacterial [13].…”

Section: Introductionmentioning

confidence: 99%

Comparative Nephroprotective Effect of Telfaria occidentalis Leaf Extracts

Elliot

2023

Int. J. Res. Publ. Rev.

View full text Add to dashboard Cite

The kidneys play a vital role in the excretion of waste products and toxins such as urea, creatinine and uric acid, regulation of extracellular fluid volume, serum osmolality and electrolyte concentrations, as well as the production of hormones like erythropoietin and 1,25 dihydroxy vitamin D and renin. In this study, the nephroprotective effect of Telfaria occidentalis leaf extract against oxidative stress-induced kidney damage with 2,4-dinitrophenyl hydrazine in Albino rats was investigated. Male rats received 40 mg/kg body weight of 2,4-DNPH except the negative contol. The resulting oxidative stressed kidney damaged rats were pretreated with ethanol and aqueous leaf extracts of Telfaria occidentalis for 21 days. After the period of treatments, hematological evaluations were carried out on the serum of the animals. Results showed significant elevated serum creatinine, urea, bilirubin, ammonia but a decrease in bicarbonate and erythropoietin levels when compared with the normal control rats. But an increase in serum serum creatinine, urea, bilirubin, ammonia was ameliorated in groups pretreated with the same concentrations of ethanol and aqueous leaf extracts of Telfaria occidentalis. Also, the decrease in serum levels of bicarbonate and erythropoietin in 2,4-DNPHintoxicated rats was significantly (p<0.0001) elevated in groups pretreated with the same concentrations of ethanol and aqueous leaf extracts of Telfaria occidentalis when compared with the positive control group. There was no significant (p<0.0001) difference in the pharmacological effect of both ethanol and aqueous leaf extracts of Telfaria occidentalis in the treated animals and this further support the oral consumption of fluted pumpkin leaf. The serum kidney function parameters indicate that the toxicant actually caused serious oxidative damage but treatment with extract help to remedy the observed damage. This implies that the leaf extract of Telfaria occidentalis helps to mitigate the oxidative damage caused by 2,4-dinitophenyl hydrazine. This result implies that fluted pumpkin consumption can help to heal oxidative damage condition and protect against deleterious effect of oxidative stress on the kidney.

show abstract

Section: Introductionmentioning

confidence: 99%

Comparative Nephroprotective Effect of Telfaria occidentalis Leaf Extracts

Elliot

2023

Int. J. Res. Publ. Rev.

View full text Add to dashboard Cite

show abstract

Investigation of the Hepatoprotective Potential of Fractions and Phytosomal Complexes of Telfairia Occidentalis Hook F Leaf Extracts on Alcohol-Induced Hepatotoxicity in Rat Models

Omeh,

Okolo,

Ugwueze

et al. 2024

IND. DRU.

View full text Add to dashboard Cite

The aim of this work was to evaluate the hepatoprotective potential of fractions and phytosomal complexes of Telfairia occidentalis leaf extracts on ethanol-induced hepatotoxicity in rat models. Phytosomal complexes of ethanol extract fractions were prepared by the thin film hydration technique. Hepatoprotective activities were evaluated by biochemical assays and histopathological examination of liver sections. Intoxication of animals with pure ethanol significantly (p < 0.05) elevated their liver enzyme titers, whereas co-administration with various extracts and phytosomal complexes reversed the increases. Histopathological findings revealed liver tissue protective effects of the extracts with the phytosomal complexes exhibiting greater effects (p < 0.05). Significant differences at p ≤ 0.05 were observed in the liver indices of animals treated with co-administered ethanol and extract fractions or phytosomes complexes versus the positive control group. T. occidentalis leaf extract formulated as phytosomes, therefore, has good potential of enhancing the hepatoprotective activities of the extract.

show abstract

Aqueous Leaves Extract of Telfairia occidentalis (Fluted Pumpkin) Protects Against Gastric Ulcer and Inhibits Intestinal Motility in Wistar Rats

Cited by 2 publications

References 35 publications

Comparative Nephroprotective Effect of Telfaria occidentalis Leaf Extracts

Comparative Nephroprotective Effect of Telfaria occidentalis Leaf Extracts

Investigation of the Hepatoprotective Potential of Fractions and Phytosomal Complexes of Telfairia Occidentalis Hook F Leaf Extracts on Alcohol-Induced Hepatotoxicity in Rat Models

Contact Info

Product

Resources

About