The kidneys play a vital role in the excretion of waste products and toxins such as urea, creatinine and uric acid, regulation of extracellular fluid volume, serum osmolality and electrolyte concentrations, as well as the production of hormones like erythropoietin and 1,25 dihydroxy vitamin D and renin. In this study, the nephroprotective effect of Telfaria occidentalis leaf extract against oxidative stress-induced kidney damage with 2,4-dinitrophenyl hydrazine in Albino rats was investigated. Male rats received 40 mg/kg body weight of 2,4-DNPH except the negative contol. The resulting oxidative stressed kidney damaged rats were pretreated with ethanol and aqueous leaf extracts of Telfaria occidentalis for 21 days. After the period of treatments, hematological evaluations were carried out on the serum of the animals. Results showed significant elevated serum creatinine, urea, bilirubin, ammonia but a decrease in bicarbonate and erythropoietin levels when compared with the normal control rats. But an increase in serum serum creatinine, urea, bilirubin, ammonia was ameliorated in groups pretreated with the same concentrations of ethanol and aqueous leaf extracts of Telfaria occidentalis. Also, the decrease in serum levels of bicarbonate and erythropoietin in 2,4-DNPHintoxicated rats was significantly (p<0.0001) elevated in groups pretreated with the same concentrations of ethanol and aqueous leaf extracts of Telfaria occidentalis when compared with the positive control group. There was no significant (p<0.0001) difference in the pharmacological effect of both ethanol and aqueous leaf extracts of Telfaria occidentalis in the treated animals and this further support the oral consumption of fluted pumpkin leaf. The serum kidney function parameters indicate that the toxicant actually caused serious oxidative damage but treatment with extract help to remedy the observed damage. This implies that the leaf extract of Telfaria occidentalis helps to mitigate the oxidative damage caused by 2,4-dinitophenyl hydrazine. This result implies that fluted pumpkin consumption can help to heal oxidative damage condition and protect against deleterious effect of oxidative stress on the kidney.