Pinostrobin inhibits proliferation and induces apoptosis in cancer stem-like cells through a reactive oxygen species-dependent mechanism

Abstract

The anti-proliferative potential of pinostrobin, a dietary flavonoid, is evaluated against cancer stem-like cells.

Induction of apoptosis in human colorectal cancer cells by nanovesicles from fingerroot (Boesenbergia rotunda (L.) Mansf.)

“…Our FDNVs contained alkaloids, phenolics, lipids, and organic compounds, which illustrates the diversity of phytochemical constituents in FDNVs. There have been reports of anticancer potentials of phenolic compounds via ROS-mediated apoptosis, such as naringenin chalcone [ 36 ], pinostrobin [ 37 ], and pinocembrin [ 38 ]. In addition, valerenic acid (lipid) and darymid A (alkaloid) have also been found to possess anticancer activity [ 39 , 40 ].…”

“…The secondary metabolites present in plants, such as flavonoids, fatty acids, and proteins have been shown to induce ROS generation, i.e. pinostrobin [ 37 ], linoleic acid [ 50 ], and phospholipase D [ 51 ], respectively. Our study showed that ROS levels were elevated in HT-29 and HCT116 cells after FDNVs treatment.…”

“…Boesenbergin A, a chalcone from fingerroot induced oxidative stress-mediate apoptosis in lung adenocarcinoma cells (A549) [ 9 ]. Pinostrobin, a flavanone in Fingerroot, exhibited anti-proliferation effects and induced apoptosis in cancer stem-like cells through a ROS-dependent mechanism [ 37 ]. Additionally, nanovesicles from several plants, including lemon and ginseng, have also reported ROS-mediated apoptosis [ 21 , 31 ].…”

Natural Phytochemicals Derived from Gymnosperms in the Prevention and Treatment of Cancers

“…Furthermore, the ability of pinostrobin to prevent the cyclooxygenase enzyme pathway indicates anti-inflammatory potential [ 27 ]. In addition, pinostrobin has significant effects on cell cycle arrest, growth inhibition, and apoptosis in many cancers [ 48 ]. Jaudan et al demonstrated that HeLa cells are more sensitive to pinostrobin than other cancer cell lines in vitro [ 27 ].…”

The activity of bioactive compounds against several diseases by modulating autophagy

“…Pinostrobin (PN) (Fig. 1d) is one of the most flavones found in fingerroot (Boesenbergia rotunda) and honey which is commonly potential as an antioxidant and contribute against several diseases (Fahey and Stephenson, 2002;Chahyadi et al, 2014;Patel et al, 2016;Atun et al, 2017;Jadaun et al, 2019). Even though there are few numbers of reports regarding pinostrobin, some are reported to have roles to some cancers, such as in breast cancer by binding with estrogen receptor and fibrosarcoma by upregulating the expression of p53 and decreasing activation of VEGF angiogenesis (Le Bail et al, 2000;Parwata et al, 2015).…”