Pilot study on novel skin care method by augmentation with Staphylococcus epidermidis, an autologous skin microbe – A blinded randomized clinical trial

Nodake, Yuichi; Matsumoto, S.; Miura, Ryoko; Honda, Hidetoshi; Ishibashi, Genji; Matsumoto, Shuzo; Dekio, Itaru; Sakakibara, Ryuzo

doi:10.1016/j.jdermsci.2015.05.001

Cited by 74 publications

(49 citation statements)

References 29 publications

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“…Microbes are important components of the skin. Recent clinical studies already revealed that application of natural bacteria into the skin can decrease skin pH and improve moisture retention 34 . This method opens the possibility to develop probiotic solutions that help the human skin reverting disease microbiome states to healthy ones.…”

Section: Discussionmentioning

confidence: 99%

Skin microbiome modulation induced by probiotic solutions

Paetzold¹,

Willis

Lima³

et al. 2018

Preprint

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BackgroundThe skin is colonized by a large number of microorganisms, of which most are beneficial or harmless. However, disease states of skin have specific microbiome compositions that are different from those of healthy skin. Gut microbiome modulation through fecal transplant has proven as a valid therapeutic strategy in diseases such as Clostridium difficile infections. Therefore, techniques to modulate the skin microbiome composition may become an interesting therapeutic option in diseases affecting the skin such as psoriasis or acnes vulgaris.Here we have used mixtures of different skin microbiome components to alter the composition of a recipient skin microbiome.ResultsWe show that after sequential applications of a donor microbiome, the recipient microbiome becomes similar to that of the donor. After intervention, an initial, week-long phase is characterized by dominance of donor strains. The level of engraftment depends on the composition of the recipient and donor microbiomes, and the applied bacterial load. We observed higher engraftment using a multi-strain donor solution with recipient skin rich in Cutibacterium acnes subtype H1 and Leifsonia.ConclusionsWe have demonstrated the use of living bacteria to modulate skin microbiome composition.

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Section: Discussionmentioning

confidence: 99%

Skin microbiome modulation induced by probiotic solutions

Paetzold¹,

Willis

Lima³

et al. 2018

Preprint

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“…In contrast, twice-weekly application of a topical gel containing S. epidermidis changes the host skin microbiome and leads to robust colonization. 55 Thus, utilization of a skin commensal like S. epidermidis may be more suitable than N. eutropha, particularly as S. epidermidis has been shown to inhibit C. acnes growth in vitro. 56 Topical probiotics may also include C. acnes bacteriophages, which are viruses that can lyse host bacteria.…”

Section: Acne Vulgarismentioning

confidence: 99%

Changing our microbiome: probiotics in dermatology

et al. 2019

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Summary Background Commensal bacteria are a major factor in human health and disease pathogenesis. Interest has recently expanded beyond the gastrointestinal microbiome to include the skin microbiome and its impact on various skin diseases. Objectives Here we present current data reviewing the role of the microbiome in dermatology, considering both the gut and skin microflora. Our objective was to evaluate whether the clinical data support the utility of oral and topical probiotics for certain dermatological diseases. Methods The PubMed and ClinicalTrials.gov databases were searched for basic science, translational research and clinical studies that investigated differences in the cutaneous microbiome and the impact of probiotics in patients with atopic dermatitis, acne vulgaris, psoriasis, chronic wounds, seborrhoeic dermatitis and cutaneous neoplasms. Results Few clinical trials exist that explore the utility of probiotics for the prevention and treatment of dermatological diseases, with the exception of atopic dermatitis. Most studies investigated oral probiotic interventions, and of those utilizing topical probiotics, few included skin commensals. In general, the available clinical trials yielded positive results with improvement of the skin conditions after probiotic intervention. Conclusions Oral and topical probiotics appear to be effective for the treatment of certain inflammatory skin diseases and demonstrate a promising role in wound healing and skin cancer. However, more studies are needed to confirm these results. What's already known about this topic? The microbiome plays a role in human health and disease pathogenesis. Probiotics can manipulate the host microbiome and may confer health benefits for patients. Research to date has already begun to explore the utility of oral and topical probiotics for certain dermatological diseases. What does this study add? This review presents basic science and clinical trial data to support the role of the gut and skin microbiome in dermatology. Current data are reviewed on the use of probiotics in the prevention and treatment of skin diseases, including atopic dermatitis, acne vulgaris, psoriasis, seborrhoeic dermatitis, chronic wounds and cutaneous neoplasms. Future probiotic interventions are proposed.

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“…[10]. In Übereinstimmung hiermit ergab eine randomisierte klinische Studie, dass die Behandlung der Haut mit expandierten autologen S. epidermidis zur Aufrechterhaltung eines leicht sauren pH-Wertes der Haut von etwa 5,0 bei erhöhten epidermalen Mengen an Milch- und Propionsäure sowie Lipiden führte [13]. …”

Section: Mykosenunclassified

pH-Wert und mikrobielle Infektionen

Rippke¹,

Berardesca²,

Weber³

2019

Kompass Dermatol

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Ein durchgängig saurer pH-Wert im Stratum corneum ist ein wesentlicher Bestandteil des Schutzsystems der Haut, der eine feindliche Umgebung für die Besiedelung durch pathogene Mikroorganismen schafft. Doch diese Barriere kann bei gesunder und umso mehr bei geschädigter Haut durchbrochen werden. Mykosen, Windel-/Inkontinenz-assoziierte Dermatitis und Wundheilung sind Beispiele für Situationen, in denen durch veränderte Haut- oder Umgebungsbedingungen eine mikrobielle Infektion begünstigt wird. Pilze verfügen über ein komplexes System, mit dem sie den pH-Wert ihrer Umgebung erfassen, um durch entsprechende Stoffwechselreaktionen ihre Adhäsion, Vermehrung und Invasion zu gewährleisten, indem mikrobielle Metaboliten den pH-Wert der Haut weiter erhöhen, bis schließlich eine klinisch manifeste Infektion (Mykose) vorliegt. Menschen mit Diabetes, bei denen der pH-Wert der Haut in intertriginösen Bereichen erhöht ist, sind besonders anfällig für Candidosen. Bei Windeldermatitis und Inkontinenz-assoziierter Dermatitis ist die Ursache für den erhöhten pH-Wert der Haut und die Schädigung der Hautbarrierefunktion der Kontakt mit Urin und Fäzes, ob unter Okklusion oder nicht, und durch Wirts- und mikrobielle Enzyme und Metaboliten wird dieser Zustand aufrechterhalten. Das führt zur Dezimierung der schützenden residenten Mikroflora und ihrer Überwucherung durch Pilze, meist Candida albicans. Die Hautpflege mit leicht sauren Produkten kann helfen, diese Form von Dermatitis zu verhindern und zu behandeln. Der Prozess der Wundheilung ist eine komplexe Abfolge biologischer Ereignisse, die mit dem pH-Wert der Umgebung korrelieren, welcher die verschiedenen Phasen der Wundheilung beeinflusst. Der pH-Wert ist für die adäquate Aktivität von Immunzellen und wichtigen Enzymen ebenso bestimmend wie für die Biofilmbildung. Wenn der Heilungsprozess gestört wird, können Wunden chronisch werden und sind dann durch einen neutralen bis leicht alkalischen pH-Wert gekennzeichnet. Vor diesem Hintergrund könnten die Überwachung des pH-Wertes und die Herstellung eines sauren Milieus als Wundbehandlungsmaßnahme sinnvoll sein.

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Pilot study on novel skin care method by augmentation with Staphylococcus epidermidis, an autologous skin microbe – A blinded randomized clinical trial

Cited by 74 publications

References 29 publications

Skin microbiome modulation induced by probiotic solutions

Skin microbiome modulation induced by probiotic solutions

Changing our microbiome: probiotics in dermatology

pH-Wert und mikrobielle Infektionen

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