Phytochemical Investigation of the Medicinal Plant Moricandia Arvensis L. From Algerian Sahara

Berreghioua, Abdelaziz; Cheriti, Abdelkrim

doi:10.22159/ajpcr.2018.v11i5.23822

Cited by 5 publications

(12 citation statements)

References 10 publications

(15 reference statements)

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“…Methanol extract of M. arvensis used in the bioassays contained flavonoids which shared the general chemical features found for these phytochemicals in several other Brassicaceae [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 35 ], that is the occurrence of quercetin and kaempferol as the main aglycones, the O -glycosylation and the presence of sophorose and rutinose as common disaccharides. Compositional differences were however observed compared to previous reports on M. arvensis [ 12 , 13 , 14 ], which should not be considered unexpected, taking into account the type of plant tissue and the extraction procedure/solvent used in this investigation.…”

Section: Discussioncontrasting

confidence: 80%

“…M. arvensis which belongs to the botanical family of Brassicaceae, it was therefore expected to contain glucosinolates and phenolic compounds. Previous investigations on the content of these specialized metabolites in the seeds [ 34 ] as well as in mature tissues [ 14 ] of M. arvensis from Algeria indicated the presence of GLSs of the indole structural type. Adversely, the analysis of the aerial parts of our plants collected at anthesis displayed a different composition of GLSs, only including aliphatic GLSs and one benzyl derivative ( Table 3 ).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the known compounds β- d -glucopyranosyl-4-hydroxybenzoate, methyl-4- O -β- d -glucopyranosyl-caffeate, 1- O -caffeoyl-β- d -glucopyranoside and 2-phenylethyl-β- d -glucopyranoside. Recently, some flavone (5,7-dihydroxy-3,6,4′-trimethoxyflavone; 5,7,4′-trihydroxy-3,6,8,3′-tetramethoxy-flavone; 3, 3′,4′,5,7-pentahydroxy-flavone) and flavonol (3-glucosyl-3′,4′,5,7-tetrahydroxy-flavonol and kaempferol-3-digalactopyranoside) constituents have been identified in a water extract from the leaves of M. arvensis collected in the Algerian Sahara [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical and Biological Profile of Moricandia arvensis (L.) DC.: An Inhibitor of Pancreatic Lipase

et al. 2018

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Pancreatic lipase, a key enzyme for lipid absorption, is one of the most important targets for the treatment of obesity, while natural compounds have recently attracted much interest as potential inhibitors of this enzyme. Here, in an attempt to find new effective agents, the methanolic extract from Moricandia arvensis (L.) DC. and its sub-extracts were investigated for their potential inhibitory activity. The ability to inhibit pancreatic lipase was verified through the in vitro evaluation of the prevention of p-nitrophenyl caprylate hydrolysis. The antioxidant activity was also verified by means of DPPH and β-carotene bleaching tests. Compositional profiling revealed that flavonoid glycosides were the main specialized metabolites present in the methanolic extract from the aerial parts of the plant with kaempferol and quercetin representing the two O-glycosylated aglycones. Kaempferol-3-O-β-(2″-O-glucosyl)-rutinoside and kaempferol-3-O-a-arabinosyl-7-O-rhamnoside were the most abundant flavonols. The crude methanolic extract and the dichloromethane and ethyl acetate sub-extracts showed a strong lipase inhibitory activity, with IC50 values of 2.06 ± 0.02, 1.52 ± 0.02 and 1.31 ± 0.02 mg/mL, respectively. The best capacity to scavenge DPPH radical was detected for the ethyl acetate sub-extract (IC50 = 171.9 ± 1.0 µg/mL), which was also effective in protecting linoleic acid from peroxidation (IC50 = 35.69 ± 2.30 µg/mL). Obtained results support the hypothesis that M. arvensis can be a source of bioactive phytochemicals for the pharmacological inhibition of dietary lipids absorption.

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Section: Discussioncontrasting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Phytochemical and Biological Profile of Moricandia arvensis (L.) DC.: An Inhibitor of Pancreatic Lipase

et al. 2018

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“…For example, Daphne gnidium extracts are essential oils that contains fatty acids, coumarins, avonoids, terpenoids, and alkanes. Moricandia arvensis leaves contain saponins, tannins, avonoids, cardenolides, and alkaloids [9]. Vernonia anthelmintica contains steroids, avonoids, carbohydrates, fatty acids, sesquiterpene lactones, and terpenes [10] Medicago sativa L. is a large genus of the Leguminosae tribe, with around 83 distinct species.…”

Section: Introductionmentioning

confidence: 99%

The effect of Medicago sativa extract and light on skin hypopigmentation disorders in C57/BL6 mice

Ubaydee

Issa

Hajleh

et al. 2022

J of Cosmetic Dermatology

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Vitiligo is a common depigmentation skin disease that affects the quality of life in many patients. This study aims to investigate the effect of Medicago sativa methanol extract on the treatment of skin hypopigmentation disorders. Antioxidant activity and phytochemical constituents of the extract were determined using DDPH assay, Folin-Ciocalteu, AlCl 3 and HPLC-MS/MS analysis. Oil in water (o/w) creams were prepared to contain the methanolic extract, and applied to hydroquinone-induced depigmentation in vivo model and further challenged in combination with UVA light exposure. Skin and hair colors were visually scored and evaluated at different time intervals, and histopathological examinations of skin layers and hair follicles were performed. Results showed total phenolic content of 187.70 mg/g, equivalent to gallic acid, and total avonoid content of 21.97 mg/g, equivalent to quercetin.Most interestingly, the extract showed an antioxidant percent inhibition activity of 71%. Moreover, the HPLC-MS/MS detection revealed the presence of 18 compounds including P-coumaric acid and antioxidants avonoids, of those are 7 compounds not previously detected in this species. The in vivo study showed a remarkable skin and hair pigmentation effect on plant extract treated groups, compared to the reference, placebo and control groups. Histopathological examinations showed the growth of coloured hair follicles in the dermis and epidermis layers of the extract treated mice. In conclusion, the study suggests the use of M. sativa extract in enhancing the pigmentation process in hypopigmented skin and hair if combined with UVA light. Therefore, M. sativa extract can be considered a potential treatment for vitiligo.

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“…South Algeria with its rich floral resources and ethnobotanical history is an ideal place of new pharmacological compounds [1,2]. One of these floral resources is Bubonium graveolens (Forssk.…”

Section: Introductionmentioning

confidence: 99%

Bioassay-Guided Isolation of the Major Compound With Antioxidant Activity From the Algerian Medicinal Plant Bubonium Graveolens

Messaoudi

Cheriti

Bourmita

2018

Asian J Pharm Clin Res

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Objective: The objective of this research was to isolate and identify the major compound from the antioxidant extract obtained from the leaves of Bubonium graveolens.Methods: A bioguided fractionation was done to isolate and identify the major compound responsible of the antioxidant activity. The chemical structure of the isolated natural compound was established by spectroscopic means including UV, Fourier transform infrared, 1H NMR, and13C NMR. The purified compound was accurately tested for its antioxidant activity by the 2, 2-diphenyl-1-picrylhydrazyl assay at 517 nm.Results: The major compound named myricetin 3′-O-rhamnoside was isolated for the 1st time from the leaves of B. graveolens a medicinal specie of Algerian Sahara belonging to the Asteraceae family. The study showed that the myricetin 3ʹ-O-rhamnoside has an antioxidant potential 59% when compared with standard ascorbic acid with an IC 50=0.916 mg/ml.Conclusion: In the present work, it was possible to isolate and identify for the 1st time the major compound from the antioxidant fraction of B. graveolens.

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Phytochemical Investigation of the Medicinal Plant Moricandia Arvensis L. From Algerian Sahara

Cited by 5 publications

References 10 publications

Phytochemical and Biological Profile of Moricandia arvensis (L.) DC.: An Inhibitor of Pancreatic Lipase

Phytochemical and Biological Profile of Moricandia arvensis (L.) DC.: An Inhibitor of Pancreatic Lipase

The effect of Medicago sativa extract and light on skin hypopigmentation disorders in C57/BL6 mice

Bioassay-Guided Isolation of the Major Compound With Antioxidant Activity From the Algerian Medicinal Plant Bubonium Graveolens

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