“…In community samples, persistent fatigue (that is symptom scores ≥half an SD from the population mean for ≥30 days) is a problem for 20% of adults in the community [1] and is associated with physical inactivity [2]. Sedentary groups with well-defined medical conditions (for example cancer and heart disease) or unexplained fatigue syndromes report improved feelings of fatigue after chronic exercise [3,4,5,6], but few studies have involved those with persistent fatigue who neither have a medical condition nor have reached diagnostic criteria for an unexplained fatigue syndrome [7,8,9,10,11,12,13].…”