“…A hydroxylated piperidine alkaloid (30) has been isolated from a small frog, Dendrobates speciosus, native to western Panama.18 Its structure is confirmed by an earlier synthesis effected before the compound was identified as a natural product.19 ( + )-N-Methylpseudoconhydrine (3 l), an alkaloid of S . African Conium spp., has been synthesized by a route starting with L-lysine and involving an anodic oxidation as key reaction (Scheme 4).,O A total synthesis of racemic prosafrinine (32), an alkaloid of the leaves of Prosopis africana, is outlined in Scheme 5 ; the final product was a mixture of 3-epimerides7 separable by HPLC. A 13C NMR analysis of (32) A review entitled ' Homochiral Compounds from Sugars ' demonstrates the relationship between hexoses and polyhydroxylated piperidine glycosidase inhibitors and summarizes syntheses of some jirimicins from them.23 A combined chemical and enzymic procedure for the synthesis of 1 -deoxynojirimycin (41) (occurring in plants of genus Morus) and l-deoxymannojirimycin (42) (occurring in Lonchocarpus pods) has been reported.…”